Lifestyle factors associated with serum N-3 fatty acid levels in breast cancer patients

Djurić, Zora; Ren, Jianwei; Brown, Patrick; Ellsworth, Jennifer S.; Sen, Ananda

doi:10.1016/j.breast.2012.02.003

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…Other limitations include the relatively short duration of the intervention and the lack of long‐term follow‐up. In addition, carotenoids are fat soluble and, given that total dietary lipids decreased, this is likely to have influence the bioavailability and absorption of carotenoids; moreover, the type of fat consumed might alter their plasma concentration . Likewise, circulating n ‐3 fatty acids levels have been shown to be affected by the quality of diet and also other lifestyle factors, including PA .…”

Section: Discussionmentioning

confidence: 99%

Changes in dietary intake, plasma carotenoids and erythrocyte membrane fatty acids in breast cancer survivors after a lifestyle intervention: results from a single‐arm trial

Buckland

Travier

Arribas

et al. 2019

J Human Nutrition Diet

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Background The influence of nutrition on breast cancer prognosis is still inconclusive and therefore dietary interventions incorporating dietary biomarkers are needed to confirm compliance with dietary goals and clarify biological mechanisms. The present study assessed whether a lifestyle intervention in breast cancer survivors could affect dietary biomarkers of fruit and vegetables and fatty acids. Methods In this phase II single‐arm trial, 37 overweight/obese early stage breast cancer patients completed a 12‐week diet and exercise intervention. The intervention involved 1‐h weekly diet sessions delivered by a dietician and 75‐min bi‐weekly physical activity sessions of moderate‐to‐high intensity led by trained monitors. Before and after the intervention, three 24‐h dietary recalls were carried out to calculate nutrient intakes and, in addition, blood samples were taken to measure plasma carotenoids, vitamin E and retinol concentrations and erythrocyte membrane fatty acid (EFA) composition. Wilcoxon signed rank tests were used to assess changes in dietary and biomarkers measurements over the intervention period. Results After the intervention, there was a significant increase in the intake of dietary carotenoids (+15.1% compared to baseline) but not plasma carotenoids levels (+6.3%). Regarding the EFA levels, we observed a significant decrease in percentage of saturated fatty acids (−1.4%) and n‐6 polyunsaturated fatty acids (−2.9%) and an increase in monounsaturated fatty acids (1.7%) and total and long‐chain n‐3 polyunsaturated fatty acids (by 13.1% and 13.7%, respectively). A favourable decrease in the ratio of long‐chain n‐6 to n‐3 polyunsaturated fatty acids (−9.1%) was also observed. Conclusions After a short‐term diet and exercise intervention in overweight/obese breast cancer survivors, we observed significant changes in dietary nutrients and fatty acid biomarkers, suggesting positive dietary changes that could be relevant for breast cancer prognosis.

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Section: Discussionmentioning

confidence: 99%

Changes in dietary intake, plasma carotenoids and erythrocyte membrane fatty acids in breast cancer survivors after a lifestyle intervention: results from a single‐arm trial

Buckland

Travier

Arribas

et al. 2019

J Human Nutrition Diet

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“…The origin and presentation of breast cancer are multifactorial and involve genetic, hormonal, environmental and nutritional factors [ 16 ]. The lipid composition of adipose tissues has been considered to be the best qualitative biomarker of past dietary intake of fatty acids [ 9 , 10 , 11 , 12 ]. The levels of DHA and EPA in this storage tissue may therefore reflect past intake of long chain FA of marine origin.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between adipose tissue-derived lipid mediators and epithelial breast tissue biology has been thoroughly investigated and several molecular pathways related to the synthesis of lipid mediators have been described [ 6 , 7 , 8 ], giving rise to the hypothesis that the fatty acid profile of triglycerides stored in the adipose tissue might influence any malignant transformation of the mammary gland. Furthermore, the composition of adipose tissue fatty acids reflects past dietary habits, a widely recognized component of the risk and behavior of breast cancer [ 9 , 10 , 11 , 12 ], and several reports of circumstantial evidence support a potential role of adipose tissue in breast cancer development and aggressiveness. If multifocality does represent expression of the pressure of this immediate environment on the entire epithelial mammary tissue to generate growth of tumors at several sites in the same breast, then lipids surrounding this tissue in a breast with multifocal tumors might differ from that of a breast with a unifocal tumor.…”

Section: Introductionmentioning

confidence: 99%

N-3 Polyunsaturated Fatty Acids of Marine Origin and Multifocality in Human Breast Cancer

et al. 2016

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ObjectiveThe microenvironment of breast epithelial tissue may contribute to the clinical expression of breast cancer. Breast epithelial tissue, whether healthy or tumoral, is directly in contact with fat cells, which in turn could influence tumor multifocality. In this pilot study we investigated whether the fatty acid composition of breast adipose tissue differed according to breast cancer focality.MethodsTwenty-three consecutive women presenting with non-metastatic breast cancer underwent breast-imaging procedures including Magnetic Resonance Imaging prior to treatment. Breast adipose tissue specimens were collected during breast surgery. We established a biochemical profile of adipose tissue fatty acids by gas chromatography. We assessed whether there were differences according to breast cancer focality.ResultsWe found that decreased levels in breast adipose tissue of docosahexaenoic and eicosapentaenoic acids, the two main polyunsaturated n-3 fatty acids of marine origin, were associated with multifocality.DiscussionThese differences in lipid content may contribute to mechanisms through which peritumoral adipose tissue fuels breast cancer multifocality.

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Omega-3 Fatty Acids for Prevention of Breast Cancer: an Update and the State of the Science

Iyengar

Hudis

Gucalp

2013

Curr Breast Cancer Rep

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The quantity and makeup of dietary fat intake are known to impact human health. Use of Omega-3 (ω-3) polyunsaturated fatty acid (PUFA) supplements has gained increasing attention for a variety of purported health benefits, including cancer prevention. Preclinical evidence has been encouraging and recent studies have expanded our understanding of the mechanisms by which ω-3 PUFAs may protect against breast cancer. However, epidemiologic studies have yielded mixed results. Recent population studies have attempted to delineate factors that may influence the effects of ω-3 PUFAs such as total fat intake and the ratio of ω-3 to ω-6 PUFA intake. Several clinical trials, including some currently ongoing, are investigating novel strategies that favorably alter endogenous fatty acid profiles in an effort to develop clinically feasible prevention methods. Identification of well-defined subpopulations that are most likely to benefit from a targeted prevention approach will likely be crucial in this effort.

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Lifestyle factors associated with serum N-3 fatty acid levels in breast cancer patients

Cited by 3 publications

References 32 publications

Changes in dietary intake, plasma carotenoids and erythrocyte membrane fatty acids in breast cancer survivors after a lifestyle intervention: results from a single‐arm trial

Changes in dietary intake, plasma carotenoids and erythrocyte membrane fatty acids in breast cancer survivors after a lifestyle intervention: results from a single‐arm trial

N-3 Polyunsaturated Fatty Acids of Marine Origin and Multifocality in Human Breast Cancer

Omega-3 Fatty Acids for Prevention of Breast Cancer: an Update and the State of the Science

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