Lifestyle factors and visceral adipose tissue: Results from the PREDIMED-PLUS study

Galmés-Panadés, Aina María; Konieczna, Jadwiga; Abete, Itziar; Colom, Antoni; Rosique-Esteban, Núria; Ma, Zhenzhen; Vázquez, Zenaida; Estruch, Ramón; Vidal, Josep; Toledo, Estefanía; Babió, Nancy; Fiol, Miguel; Casas, Rosa; Vera, Josep; Buil‐Cosiales, Pilar; Paz, José Antonio de; Goday, Albert; Salas‐Salvadó, Jordi; Ja, Martínez; Romaguera, Dora

doi:10.1371/journal.pone.0210726

Cited by 19 publications

(13 citation statements)

References 45 publications

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“…These ndings are consistent with previous cross-sectional research in adult populations [3,32,40], which have found a hazardous relationship between SB and markers of body composition, including body fat, VAT and muscle mass [3,9,32,40,41]. The present results showed that greater SB is associated with greater body fat and lower muscle mass in an aging population, resulting in greater cardiometabolic risk and disability.…”

Section: Discussionsupporting

confidence: 93%

“…The present results showed that greater SB is associated with greater body fat and lower muscle mass in an aging population, resulting in greater cardiometabolic risk and disability. In line with our ndings, other authors found that increasing total PA and MVPA improves body composition [3,8,40] and reduce the accumulation of VAT [8,10,42,43], yet no effects associated to LPA and body composition have been reported with the present results based on self-reported data.…”

Section: Discussionsupporting

confidence: 92%

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Changes in physical activity, sedentary behaviour and body composition: longitudinal analysis in the PREDIMED-Plus trial

Galmés-Panadés¹,

Konieczna²,

Varela-Mato³

et al. 2020

Preprint

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Background:The optimal distribution between physical activity (PA) levels and sedentary behaviour (SB) for the greatest benefits for body composition among older adults with overweight/obesity and chronic health conditions remains unclear. We aimed to determine the prospective association between changes in PA and in SB with concurrent changes in body composition. To examine whether reallocating inactive time into different physical activity levels was associated with 12-month change to body composition in older adults.Methods: A subsample (n=1564) of men and women (age: 55-75 years) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus trial was included in the present analysis. Participant’s were followed-up at 6- and 12-months. Physical Activity and SB were assessed using validated questionnaires. Out of 1564 participants, 388 wore an accelerometer to objectively measure inactive time and PA over a 7-day period. At each time point, participants body composition was measured using dual-energy X-ray absorptiometry (DXA). Standard covariate-adjusted and isotemporal substitution modelling were applied to linear mixed-effects models.Results:Increasing 30 minute of total PA and MVPA were associated with significant reductions in body fat (β -0.07% and -0.08%) and VAT (-13.9g, and -15.6g) at 12-months (all p-values <0.001). Reallocating 30 minute of inactive time to MVPA was associated with reductions in body fat and VAT, and with an increase in muscle mass and muscle-to-fat mass ratio (all p-values <0.001).Conclusions:At 12 months, increasing total PA and MVPA and reducing total and TV-viewing SB were associated with improved body composition in participants with overweight or obesity, and metabolic syndrome. This was also observed when reallocating 30 minute of inactive time by total PA, LPA and MVPA, with the greatest benefits observed for MVPA.Trial registration: The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Changes in physical activity, sedentary behaviour and body composition: longitudinal analysis in the PREDIMED-Plus trial

Galmés-Panadés¹,

Konieczna²,

Varela-Mato³

et al. 2020

Preprint

Self Cite

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show abstract

“…These findings are consistent with previous cross-sectional research in adult populations [ 3 , 32 , 40 ], which have found a hazardous relationship between SB and markers of body composition, including body fat, VAT and muscle mass [ 3 , 9 , 32 , 40 , 41 ]. The present results showed that greater SB is associated with greater body fat and lower muscle mass in an ageing population, resulting in greater cardiometabolic risk and disability.…”

Section: Discussionsupporting

confidence: 92%

Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial

Galmés-Panadés

Konieczna

Varela-Mato

et al. 2021

BMC Med

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Background The optimal distribution between physical activity (PA) levels and sedentary behaviour (SB) for the greatest benefits for body composition among older adults with overweight/obesity and chronic health conditions remains unclear. We aimed to determine the prospective association between changes in PA and in SB with concurrent changes in body composition and to examine whether reallocating inactive time into different physical activity levels was associated with 12-month change to body composition in older adults. Methods Longitudinal assessment nested in the PREDIMED-Plus trial. A subsample (n = 1564) of men and women (age 55–75 years) with overweight/obesity and metabolic syndrome from both arms of the PREDIMED-Plus trial was included in the present analysis. Participants were followed up at 6 and 12 months. Physical activity and SB were assessed using validated questionnaires. Out of 1564 participants, 388 wore an accelerometer to objectively measure inactive time and PA over a 7-day period. At each time point, participants’ body composition was measured using dual-energy X-ray absorptiometry (DXA). Standard covariate-adjusted and isotemporal substitution modelling were applied to linear mixed-effects models. Results Increasing 30 min of total PA and moderate-to-vigorous physical activity (MVPA) was associated with significant reductions in body fat (β − 0.07% and − 0.08%) and visceral adipose tissue (VAT) (− 13.9 g, and − 15.6 g) at 12 months (all p values < 0.001). Reallocating 30 min of inactive time to MVPA was associated with reductions in body fat and VAT and with an increase in muscle mass and muscle-to-fat mass ratio (all p values < 0.001). Conclusions At 12 months, increasing total PA and MVPA and reducing total SB and TV-viewing SB were associated with improved body composition in participants with overweight or obesity, and metabolic syndrome. This was also observed when substituting 30 min of inactive time with total PA, LPA and MVPA, with the greatest benefits observed with MVPA. Trial registration International Standard Randomized Controlled Trial (ISRCTN), 89898870. Retrospectively registered on 24 July 2014

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“…Furthermore, the present study shows that health benefits are also attained when time inactive is replaced by LPA or time in bed, with improvements on: BMI, WC, body fat, VAT, muscle mass, HbA1c, glucose, HDL and triglycerides (LPA); and BMI, WC and HbA1c (time in bed). This is of interest, as research on this area continuous to mount, however findings remain ambiguous [4, 9, 10, 13, 23–25, 23] and although there are some studies in adult population [4, 25, 28, 29], few research has been conducted in older adults [23, 26] and, as far as we know, none in individuals with overweight/obesity and metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study

Galmés-Panadés¹,

Varela-Mato²,

Konieczna³

et al. 2019

Int J Behav Nutr Phys Act

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BackgroundThis study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults.MethodsThis is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55–75 years, BMI 27–40 Kg/m2) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had ≥3 components of the metabolic syndrome. Inactive time, physical activity and time in bed were objectively determined using triaxial accelerometers GENEActiv during 7 days (ActivInsights Ltd., Kimbolton, United Kingdom). Multiple adjusted linear and logistic regression models were used. Isotemporal substitution regression modelling was performed to assess the relationship of replacing the amount of time spent in one activity for another, on each outcome, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults.ResultsInactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30 min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05).ConclusionsInactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health.Trial registrationThe trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.

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Lifestyle factors and visceral adipose tissue: Results from the PREDIMED-PLUS study

Cited by 19 publications

References 45 publications

Changes in physical activity, sedentary behaviour and body composition: longitudinal analysis in the PREDIMED-Plus trial

Changes in physical activity, sedentary behaviour and body composition: longitudinal analysis in the PREDIMED-Plus trial

Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial

Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study

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