Lifestyle factors and small intestine adenocarcinoma risk: A systematic review and meta-analysis

Bennett, Caoimhe M.; Coleman, Helen; Veal, Philip; Cantwell, Marie; Lau, Charlotte C.L.; Murray, Liam

doi:10.1016/j.canep.2015.02.001

Cited by 40 publications

(27 citation statements)

References 51 publications

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“…Chronic inflammation is associated with the formation of several malignant tumors, with Crohn's disease for example increasing the risk of SBA [8]. Patients with familial adenomatous polyposis (FAP), hereditary non-polyposis colorectal cancer (HNPCC), Peutz-Jeghers syndrome, and celiac disease also show an increased risk of SBA development [9,10]. To our knowledge, this is the first report of a patient with simultaneous multiple synchronous SBA and pulmonary tuberculosis.…”

Section: Discussionmentioning

confidence: 90%

Misdiagnosis of multiple synchronous small bowel adenocarcinomas as intestinal tuberculosis: a case report

Chen

Cui

et al. 2020

BMC Gastroenterol

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Background: Small bowel adenocarcinoma (SBA) is a rare malignancy that primarily occurs in the duodenum. Multiple synchronous SBA is unique rare and difficult to diagnose due to non-specific disease presentation. Protocols to identify multiple synchronous SBA during early disease stages are urgently required. Case presentation: An elderly man experienced left lower abdominal pain and melena for 3 months. Abdominal CT showed thickening of the multiple segmental small intestinal walls. As the patient had pulmonary tuberculosis simultaneously, he was misdiagnosis as intestinal tuberculosis and received anti-spasm therapy. The treatment delayed radical resection surgery and the patient underwent palliative segmental resection of the jejunum after 4 months due to intestinal obstruction. Resected specimens showed multiple synchronous SBA (five tumors). The patient accepted chemotherapy postoperatively. Six months postoperatively, the patient died of brain metastasis. Conclusions: We highlight how multiple synchronous SBA is rare and easily misdiagnosed. We should rule out multiple synchronous SBA when diagnosing intestinal diseases (e.g. inflammatory bowel disease, IBS). Intestinal tuberculosis may also be one of the risk factors for multiple synchronous SBA. High-risk patients should be assessed for known tumor makers, and receive gastroscopy, enteroscopy or capsule endoscopy. Doctors should obtain the pathology under endoscopy to the greatest possible degree. For suspected patients, laparotomy should be performed.

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Section: Discussionmentioning

confidence: 90%

Misdiagnosis of multiple synchronous small bowel adenocarcinomas as intestinal tuberculosis: a case report

Chen

Cui

et al. 2020

BMC Gastroenterol

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“…A systematic review of the literature has reported that high levels of alcohol consumption, smoking, and dietary factors, including low intake of fiber and high intake of red/processed meat and sugary drinks, may increase the risk of SBA. 8 Additionally, the results of a pooled analysis of more than 500,000 subjects in the Asia Cohort Consortium reported that elevated body mass index and high alcohol consumption were associated with a nonsignificant trend toward an increased risk of SBA, although this analysis did not identify smoking as a risk factor. 9…”

Section: Lifestyle Factorsmentioning

confidence: 92%

Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology

Benson

Venook

Al-Hawary

et al. 2019

Journal of the National Comprehensive Cancer Network

121

128

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Small bowel adenocarcinoma (SBA) is a rare malignancy of the gastrointestinal tract that has increased in incidence across recent years. Often diagnosed at an advanced stage, outcomes for SBA are worse on average than for other related malignancies, including colorectal cancer. Due to the rarity of this disease, few studies have been done to direct optimal treatment, although recent data have shown that SBA responds to treatment differently than colorectal cancer, necessitating a separate approach to treatment. The NCCN Guidelines for Small Bowel Adenocarcinoma were created to establish an evidence-based standard of care for patients with SBA. These guidelines provide recommendations on the workup of suspected SBA, primary treatment options, adjuvant treatment, surveillance, and systemic therapy for metastatic disease. Additionally, principles of imaging and endoscopy, pathologic review, surgery, radiation therapy, and survivorship are described.

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“…The pooled RR for individuals in the highest versus lowest category of smoking was 1.24 (95% CI, 0.71-2.17). In relation to dietary factors, high fiber intake and normal body weight may be protective, while high intake of red/processed meat and sugary drinks may increase risk (Bennett et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Clinical, Radiologic, and Endoscopic Manifestations of Small Bowel Malignancies: a First Report from Thailand

Tangkittikasem

Boonyaarunnate²,

Aswakul³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 16 (18), 8613-8618 IntroductionSmall bowel cancer is a rare malignancy that accounts for only 2% of all gastrointestinal cancers (Paski, 2009;Pan et al, 2011). The incidence of malignant small intestine tumors, which ranges from 0.5-1.5/100,000 in men and 0.2-1.0/100,000 in women (Parkin et al., 1992), seems to be higher in North America and Europe than Asia (Haselkorn et al., 2005). Most cases of small bowel cancer are diagnosed late in the course of the disease because of its vague clinical presentations (e.g. abdominal pain and abdominal discomfort), and patients who present with obvious clinical manifestations such as gastrointestinal bleeding, intestinal obstruction, or ascites are almost always diagnosed with advanced stage cancer. The most common malignancy lesions are adenocarcinoma, neuroendocrine tumor (NET), sarcomas, and small bowel lymphoma. However, the incidence of small bowel cancer is increasing, particularly for carcinoid tumor (Islam, 2014). The small bowel is not a common location of metastatic cancers, although there are many case reports Based on radiology and endoscopy, this study revealed upper gastrointestinal bleeding, an intra-abdominal mass, and a sub-epithelial mass as common symptoms of GIST. Obstruction and ulcerating/circumferential masses were findicative of adenocarcinoma, as revealed by radiology and endoscopy, respectively. Finally, no specific symptoms were related to lymphoma.

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Lifestyle factors and small intestine adenocarcinoma risk: A systematic review and meta-analysis

Cited by 40 publications

References 51 publications

Misdiagnosis of multiple synchronous small bowel adenocarcinomas as intestinal tuberculosis: a case report

Misdiagnosis of multiple synchronous small bowel adenocarcinomas as intestinal tuberculosis: a case report

Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology

Clinical, Radiologic, and Endoscopic Manifestations of Small Bowel Malignancies: a First Report from Thailand

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