Lifestyle effects on aging and CVD: A spotlight on the nutrient-sensing network

Yang, Kaiying; Hou, Rongyao; Zhao, Jie; Wang, Xia; Wei, Jin; Pan, Xudong; Zhu, Xiaoyan

doi:10.1016/j.arr.2023.102121

Cited by 3 publications

(2 citation statements)

References 211 publications

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“…CL is thought to be exacerbated by hearing impairment, but this change has also been noted in some cases of visual impairment ( Golzan et al, 2017 ; Vu et al, 2021 ). Age has long been recognized as one of the main causative factors in the co-morbidity hypothesis; however, aging can lead to a variety of diseases and sensory loss, such as cardiovascular disease ( Yang et al, 2023 ), cerebrovascular disease ( Romay et al, 2024 ), and vision decline ( Vanhunsel et al, 2021 ). All of these diseases can lead to CI and these findings seem to support that age, rather than ARHL, is the underlying cause of CI.…”

Section: Discussionmentioning

confidence: 99%

Sensorineural hearing loss and cognitive impairment: three hypotheses

Zhao,

Wang,

Cui

et al. 2024

Front. Aging Neurosci.

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Sensorineural hearing loss (SNHL) is a category of hearing loss that often leads to difficulty in understanding speech and other sounds. Auditory system dysfunction, including deafness and auditory trauma, results in cognitive deficits via neuroplasticity. Cognitive impairment (CI) refers to an abnormality in the brain’s higher intellectual processes related to learning, memory, thinking and judgment that can lead to severe learning and memory deficits. Studies have established a strong correlation between SNHL and CI, but it remains unclear how SNHL contributes to CI. The purpose of this article is to describe three hypotheses regarding this relationship, the mainstream cognitive load hypothesis, the co-morbidity hypothesis, and the sensory deprivation hypothesis, as well as the latest research progress related to each hypothesis.

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Section: Discussionmentioning

confidence: 99%

Sensorineural hearing loss and cognitive impairment: three hypotheses

Zhao,

Wang,

Cui

et al. 2024

Front. Aging Neurosci.

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“…Cardiovascular disease (CVD) is a prevalent and life-threatening condition worldwide, with mortality and morbidity rates exceeding those of cancer [1]. High levels of reactive oxygen species (ROS) induce myocardial cell damage, playing a significant role in the pathogenesis of many heart diseases, including cardiac hypertrophy, heart failure, myocardial infarction, and myocardial ischemia/reperfusion injury.…”

Section: Introductionmentioning

confidence: 99%

Anthocyanin of Black Highland Barley Alleviates H2O2-Induced Cardiomyocyte Injury and Myocardial Infarction via Activating the Phosphatase and Tensin Homolog/Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

Liu,

Shu,

et al. 2024

Foods

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Cardiovascular disease (CVD) represents a substantial global health challenge, with its impact on mortality and morbidity rates surpassing that of cancer. The present study was designed to explore the cardioprotective properties of anthocyanin (ACN), a compound derived from black barley, against oxidative stress-induced damage in myocardial cells and to uncover the molecular mechanisms at play. Utilizing both in vitro and in vivo experimental models, our findings indicate that ACN notably reduced cell damage caused by oxidative stress and effectively prevented apoptosis. High-throughput RNA sequencing analysis has shed light on the mechanism by which ACN achieves its antioxidative stress effects, implicating the PTEN-Akt signaling pathway. ACN was found to modulate PTEN expression levels, which in turn influences the Akt pathway, leading to a reduction in apoptotic processes. This novel insight lays the groundwork for the potential clinical utilization of ACN in the management of CVD. While this study has shed light on some of the functions of ACN, it is important to recognize that natural compounds often interact with multiple molecular targets and engage in intricate signaling cascades. Future research endeavors will concentrate on further elucidating the regulatory mechanisms by which ACN influences PTEN expression, with the goal of enhancing our comprehension and expanding the therapeutic potential of ACN in the treatment of cardiovascular conditions.

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