Lifestyle, clinical, and occupational risk factors of recurrent stroke among the working-age group: A systematic review and meta-analysis

Chiangkhong, Araya; Suwanwong, Charin; Wongrostrai, Yupha

doi:10.1016/j.heliyon.2023.e13949

Cited by 4 publications

(5 citation statements)

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“…[21] Several studies have demonstrated that smoking is a strong risk factor for ischemic stroke, as current smokers have 2 to 6 more chances of developing stroke. [22][23][24][25][26] Smoking leads to accelerated atherosclerosis, including ATS of the carotid and cerebral arteries, with high levels of oxidized LDL-C, homocysteine, and other proinflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

“…[21] Several studies have demonstrated that smoking is a strong risk factor for ischemic stroke, as current smokers have 2 to 6 more chances of developing stroke. [22–26] Smoking leads to accelerated atherosclerosis, including ATS of the carotid and cerebral arteries, with high levels of oxidized LDL-C, homocysteine, and other proinflammatory markers. Changes in the arterial walls lead to endothelial dysfunction, which translates into reduced vasodilation through impaired nitric oxide production and increased rigidity.…”

Section: Discussionmentioning

confidence: 99%

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Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 polymorphisms and acute ischemic stroke

Iluţ,

Vesa,

Văcăraş

et al. 2023

Medicine

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Acute ischemic stroke is a major cause of morbidity and mortality worldwide, and genetic factors play a role in the risk of stroke. Single nucleotide polymorphisms (SNPs) in the VKORC1, CYP4F2, and GGCX genes have been linked to clinical outcomes, such as bleeding and cardiovascular diseases. This study aimed to investigate the association between specific polymorphisms in these genes and the risk of developing the first episode of acute ischemic stroke in patients without a known embolic source. This retrospective, cross-sectional, observational, analytical, case-control study included adult patients diagnosed with acute ischemic stroke. The SNPs in VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 genes were genotyped and analyzed together with the demographic and clinical factors of the 2 groups of patients. The presence of SNPs in VKORC1 or CYP4F2 genes significantly increased the risk of ischemic stroke in the context of smoking, arterial hypertension, and carotid plaque burden. The multivariate logistic model revealed that smoking (odds ratio [OR] = 3.920; P < .001), the presence of carotid plaques (OR = 2.661; P < .001) and low-density lipoprotein cholesterol values >77 mg/dL (OR = 2.574; P < .001) were independently associated with stroke. Polymorphisms in the VKORC1 and CYP4F2 genes may increase the risk of ischemic stroke in patients without a determined embolic source. Smoking, the presence of carotid plaques, and high low-density lipoprotein cholesterol levels were reconfirmed as important factors associated with ischemic stroke.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 polymorphisms and acute ischemic stroke

Iluţ,

Vesa,

Văcăraş

et al. 2023

Medicine

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“…Lifestyle is dominantly responsible for increasing the risk of stroke. Ten risk factors for stroke that are related to lifestyle, which can be modified are diabetes, lack of physical activity, abnormal body fat, unhealthy eating patterns, abdominal obesity, psychological factors, smoking habits, heart disease, alcohol consumption, and hypertension (Chiangkhong et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

“…in 1 year and 20 -40% in 5 years (Chiangkhong et al, 2023), so sufferers must know about stroke and carry out activities as well as effective care and management to prevent recurrent strokes and other health complications.…”

Section: Discussionmentioning

confidence: 99%

Identification Of Clinical Pathway Models To Prevent Complications And Improve The Quality Of Life Of Stroke Patients

Asmirajanti

2023

jika

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Stroke is a disease with high cost, high volume, and high risk. The burden of these costs will increase if you experience complications that often occur in sufferers. This study aimed to identify a clinical pathway model to prevent complications and improve the quality of life of stroke patients. This study is a quantitative descriptive study with crossectional, with 95 samples of stroke patients who have been treated for at least 1 day, can communicate 2 ways at Hospital dr. Chasbullah Abdulmadjid Bekasi City, and who have studied ethical feasibility. Participants must fill out informed consent. Data were collected using questionnaires and analyzed using univariate analysis. The results showed that the most participants were aged between 45 -59 years (43.2%), male (61.1%). Hypertension, disease before stroke (71.9%), and 2 attacks (10.5%). (51.6%) were unaware of stroke with symptoms of muscle weakness (87.4%), (45.3%) difficulty speaking, and (17.2%) blurred vision. (46.9%) complications of paralysis. Activity daily living eating and drinking (55.8%), (58.95) personal hygiene, (62.1%) elimination, (68.4%) ambulation, (65.3%) mobilization, and (54.7%) rest/sleep should be assisted. Treatment was carried out by taking medication (89.5%) and control to health facilities (75.8%), but (75.8%) did not carry out rehabilitation and exercise (54.7%). There are still many participants who do not know about stroke well, which affects their independence in carrying out activities. Therefore, a clinical pathway model is needed that is used as a reference in providing information and education to stroke patients, to prevent complications and improve the quality of stroke patients.

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“…The first 3 months following the initial attack are the most critical for recurrence [8]. Moreover, the meta-analysis indicated that factors such as diabetes mellitus, smoking status, peripheral artery disease, hypercoagulable state, depression, 24-hour minimum systolic blood pressure (BP), 24-hour maximum diastolic BP, age, family history of stroke, National Institutes of Health Stroke Scale score status, hypertension, and history of cardiac disease were found to influence the recurrence of stroke [9,10].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of a Health Education Program for Patients Who Had a Stroke and Their Caregivers by Controlling Modifiable Risk Factors to Reduce Stroke Recurrence in a Tertiary Hospital in Bangladesh: Protocol for a Randomized Controlled Trial

Afrin,

Khan,

Das

et al. 2023

JMIR Res Protoc

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Background Stroke is a significant public health concern that causes severe and long-lasting disability. The recurrence of stroke is increasing due to lack of patients’ knowledge and compliance with treatment to control modifiable risk factors and lifestyle changes. Health education can be an effective way to increase knowledge about behavioral changes in patients who had a stroke. Objective The aim of this study is to evaluate the effectiveness of a health education program in Bangladesh for patients who had their first stroke and their family caregivers in order to reduce the recurrence of stroke by controlling modifiable risk factors. Methods This is a parallel, open-label, prospective randomized controlled trial conducted at the National Institute of Neurosciences & Hospital in Dhaka, Bangladesh. We enrolled ≥18-year-old patients of both sexes who had a history of first stroke attack (transient ischemic attack, hemorrhagic stroke, lacunar stroke, atherothrombotic stroke, or cardioembolic stroke). We stratified patients into those aged <65 years and those aged ≥65 years and according to types of strokes for randomization. Our estimated sample size was 432. The intervention group receives face-to-face counseling on lifestyle modifications, blood pressure monitoring, and medication compliance–related health education during enrollment and monthly follow-ups. However, the control group receives only usual care from the hospital. The primary end point of this study is the reduction in the stroke recurrence rates at the end of the 12-month follow-up period. The secondary end points are to (1) assess the occurrence of all adverse events such as other cardiac events and all-cause mortality, (2) evaluate the status of the controlling modifiable risk factors such as blood pressure, glycated hemoglobin, and non–high-density lipoprotein cholesterol, (3) assess the knowledge related to stroke by using the investigator-developed questionnaire, (4) evaluate the lifestyle behavior related to stroke by using the investigator-developed questionnaire, (5) assess medication adherence, and (6) evaluate the quality of life of patients who had a stroke and their family caregivers. The evaluation points will be at baseline, 6 months, and 12 months for both groups. Results Patients’ enrollment started on October 2022, and follow-up will be completed in March 2024. A total of 432 participants were included in both the intervention (n=216) and control groups (n=216). This study was approved by the institutional review board and the ethics review board of the National Institute of Neurosciences & Hospital (IRB/NINSH/2022/151) on August 30, 2022. Conclusions Our health education program is expected to reduce the recurrence of stroke and improve the quality of life of patients who have had the first stroke. The results of this study will provide insights into the importance of health education for (self)-management and prevention of stroke. Trial Registration ClinicalTrials.gov NCT05520034; https://clinicaltrials.gov/ct2/show/NCT05520034 International Registered Report Identifier (IRRID) DERR1-10.2196/51178

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Lifestyle, clinical, and occupational risk factors of recurrent stroke among the working-age group: A systematic review and meta-analysis

Cited by 4 publications

References 59 publications

Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 polymorphisms and acute ischemic stroke

Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 polymorphisms and acute ischemic stroke

Identification Of Clinical Pathway Models To Prevent Complications And Improve The Quality Of Life Of Stroke Patients

Effectiveness of a Health Education Program for Patients Who Had a Stroke and Their Caregivers by Controlling Modifiable Risk Factors to Reduce Stroke Recurrence in a Tertiary Hospital in Bangladesh: Protocol for a Randomized Controlled Trial

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