Lifestyle Characteristics in Women Carriers of BRCA Mutations: Results From an Italian Trial Cohort

Bruno, Eleonora; Oliverio, Andreina; Paradiso, Angelo; Daniele, Antonella; Tommasi, Stefania; Terribile, Daniela; Filippone, Alessio; Digennaro, Maria; Pilato, Brunella; Danza, Katia; Guarino, Donatella; Rossi, Cristina; Rossi, Maria Maddalena; Venturelli, Elisabetta; Giussani, Marta; Peissel, Bernard; Pasanisi, Patrizia

doi:10.1016/j.clbc.2020.11.002

Cited by 13 publications

(17 citation statements)

References 25 publications

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“…The Italian multicenter, prospective, randomized controlled trial (NCT03066856) aimed at investigating the effect of the adoption of the Mediterranean diet with moderate protein restriction in reducing IGF-I levels, body weight and other metabolic modulators of BRCA mutation penetrance. Detailed information regarding trial design and main results have already been reported [11][12][13][14][15].…”

Section: Study Subjectsmentioning

confidence: 99%

“…We have conducted a randomized controlled trial [11][12][13][14][15] in women with BRCA mutations to test whether a Mediterranean dietary intervention with moderate protein restriction significantly reduces IGF-I and other potential modulators of penetrance. A cross-sectional analysis of the baseline participants' metabolic parameters suggested that higher fat mass and the presence of four or five factors of the metabolic syndrome were significantly associated with the risk of BRCA-related cancer [15].…”

Section: Introductionmentioning

confidence: 99%

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BRCA1/2 Variants and Metabolic Factors: Results From a Cohort of Italian Female Carriers

Oliverio

Bruno

Colombo

et al. 2020

Cancers

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Women carriers of pathogenic variants (mutations) in the BRCA1/2 genes face a high lifetime risk of developing breast cancer (BC) and/or ovarian cancer (OC). However, metabolic factors may influence BRCA penetrance. We studied the association of metabolic factors with BRCA1/2 variants and the risk effect of metabolic exposures in relation to the position of the mutations within the BRCA1/2. Overall, 438 women carriers of BRCA1/2 mutations, aged 18–70, with or without a previous diagnosis of BC/OC and without metastases, who joined our randomized dietary trial, were included in the study. The pathogenic variants were divided, according to their predicted effect, into loss of function (LOF) and nonsynonymous variants. The association between metabolic exposures and variants were analyzed by a logistic regression model. LOF variant carriers showed higher levels of metabolic parameters compared to carriers of nonsynonymous variants. LOF variant carriers had significantly higher levels of plasma glucose and serum insulin than nonsynonymous variant carriers (p = 0.03 and p < 0.001, respectively). This study suggests that higher insulin levels are significantly associated with LOF variants. Further investigations are required to explore the association of metabolic factors with LOF variants and the mechanisms by which these factors may affect BRCA-related cancer risk.

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Section: Study Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

BRCA1/2 Variants and Metabolic Factors: Results From a Cohort of Italian Female Carriers

Oliverio

Bruno

Colombo

et al. 2020

Cancers

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“…Breast cancer (BC) is the most common cancer in women worldwide (and the second most common cancer overall, with nearly 2.1 million new cases diagnosed in 2018. This represents about 12% of all new cancer cases and 25% of all cancers in women [1][2][3][4]. BC is the most diagnosed neoplasm in women in Italy, after skin cancer.…”

Section: Introductionmentioning

confidence: 99%

“…However, in 2016, breast cancer was the leading cause of cancer-related deaths in women, with more than 12,000 deceased. The impact of this disease is clear not only in terms of mortality and morbidity but also in terms of economic consequences for all National Health Services (NHSs) and from a social point of view [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

An Analysis of the Social and Economic Costs of Breast Cancer in Italy

Mennini

Aurilio

Gazzillo

et al. 2021

IJERPH

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Background: Breast cancer is the most prevalent cancer affecting women and it represents an important economic burden. The aim of this study was to estimate the socio-economic burden of breast cancer (BC) in Italy both from the National Health Service (NHS) and the government perspectives (costs borne by the social security system). Methods: The economic analysis was based on the costs incurred by the NHS from 2008 to 2016 (direct costs related to hospitalizations) and by the National Social Security Institute (INPS) from 2009 to 2015 (costs of social security benefits) for patients with breast cancer. The analysis was based on the Hospital Information System (HIS) and Disability Insurance Awards databases. For both databases, patients affected by a malignant neoplasm of the female breast, carcinoma in situ, or secondary malignant neoplasm of the breast were considered. Results: Results show that more than 75,000 women were hospitalized for breast cancer every year, with an overall cost for hospitalization of about €300 million per year. From the Social Security analysis, a number of 29,000 beneficiaries each year was estimated. Considering per patient social costs, breast cancer at the primary stage cost €8828 per year, while secondary neoplasms cost €9780, with an average total economic burden of €257 million per year. Conclusions: This analysis focused on the economic impact of breast cancer in Italy, showing that an advanced stage of the disease was associated with a higher cost.

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“…We conducted a randomized controlled trial [ 10 , 11 , 12 , 13 , 14 ] of women with deleterious BRCA1 / 2 mutations to test whether a Mediterranean dietary intervention with moderate protein restriction significantly reduces IGF-I and other potential modulators of penetrance.…”

Section: Introductionmentioning

confidence: 99%

A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial

Bruno

Oliverio

Paradiso

et al. 2020

Cancers

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Background: Women carriers of BRCA1/2 mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. Methods: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. Results: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, p = 0.02), weight (−1.5 Kg versus −0.5 Kg, p < 0.001), waist circumference (−2 cm versus −0.7 cm, p = 0.01), hip circumference (−1.6 cm versus −0.5 cm, p = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, p = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, p = 0.01) with respect to the CG. Conclusions: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance.

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Lifestyle Characteristics in Women Carriers of BRCA Mutations: Results From an Italian Trial Cohort

Cited by 13 publications

References 25 publications

BRCA1/2 Variants and Metabolic Factors: Results From a Cohort of Italian Female Carriers

BRCA1/2 Variants and Metabolic Factors: Results From a Cohort of Italian Female Carriers

An Analysis of the Social and Economic Costs of Breast Cancer in Italy

A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial

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