Lifestyle Cardiovascular Risk Score, Genetic Risk Score, and Myocardial Infarction in Hispanic/Latino Adults Living in Costa Rica

Sotos‐Prieto, Mercedes; Baylin, Ana; Campos, Hannia; Qi, Lü; Mattei, Josiemer

doi:10.1161/jaha.116.004067

Cited by 21 publications

(15 citation statements)

References 47 publications

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“…1,2 During the last two decades, the rate of the death of coronary disease is decreasing in developed countries, whereas it is increasing in developing countries which is mostly because of long lifetime, urbanization and lifestyle changes. 3 In the United States, the adjusted rate of death based age due to coronary disease has been declined to two third in four last decades which is the reflection of better diagnosis and reduce risk factors and also improvement of faster treatments and interventions for control of heart diseases. ACS needs a precise diagnosis and early hospitalization and prognosis of patients is directly associated with on time conducting vascularization, so non diagnosis or delayed diagnosis can have disaster clinical effects.…”

Section: Introductionmentioning

confidence: 99%

The effect of heparin prescription before primary PCI on long-term and short-term clinical and para clinical results and the mortality of patients with acute coronary syndrome

Zamani

Abdollahi

Mardi

2018

Int J Basic Clin Pharmacol

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INTRODUCTIONCoronary artery disease (CAD) is the main cause of death, morbidity and disability in the world and their prevalence is highly increasing in developing countries. In CAD patients, acute coronary syndrome (ACS) has the most importance because of the high possibility of unpleasant cardiovascular events during follow-up was more in these patients. In 2008, 7.3 million (12.8%) out of 57 million deaths was because of myocardial infraction. In the United States, almost 650 thousand patients get new acute myocardial infraction (AMI) per year. The rate of early death (30 days) with AMI is about 30% and more than half of these cases occur before reaching to the hospital. 1,2During the last two decades, the rate of the death of coronary disease is decreasing in developed countries, whereas it is increasing in developing countries which is mostly because of long lifetime, urbanization and lifestyle changes. In the United States, the adjusted rate of death based age due to coronary disease has been declined to two third in four last decades which is the reflection of better diagnosis and reduce risk factors and also improvement of faster ABSTRACT Background: Primary PCI (PPCI) is the main reperfusion treatment for STsegment elevation myocardial infarction (STEMI). Anticoagulation therapy should be administered in patients undergoing PCI in order to limit the ischemic complications. In this study, we evaluated the effect of bolus unfractionated heparin (UFH) before PPCI on clinical outcome of patients with STEMI. Methods: In this randomized clinical trial, 196 patients (72.4% male with mean age of 63.02±13.37 years) with STEMI undergoing PPCI were randomly assigned to receive bolus UFH 60-90 U/kg in emergency room (case group) or during PCI (control group). Clinical outcomes, 30 day mortality, hematoma, left ventricle function improvement during follow-up were compared between groups. Results: In both groups there was good flow in the involved coronary artery after PCI. Case group compared to control group had significantly more cases with improved LVEF (28.1% vs. 9.7%, p=0.005). Also, case group compared to control group had more hematoma (3.1% vs. 0%, p=0.24) and higher mortality rate (6% vs. 4.2%, p=0.56) which had no significant difference between groups. Conclusions: PPCI in patients with STEMI accompanies with acceptable coronary flow irrespective of receiving bolus heparin. Receiving bolus heparin in these patients may have improved left ventricle function by increasing the rate of reflow. However, using bolus heparin did not accompany with increased rate of bleeding and had no effect on 30 day mortality rate.

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Section: Introductionmentioning

confidence: 99%

The effect of heparin prescription before primary PCI on long-term and short-term clinical and para clinical results and the mortality of patients with acute coronary syndrome

Zamani

Abdollahi

Mardi

2018

Int J Basic Clin Pharmacol

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“…Odds ratios (ORs) for MI were 2.72 (95% CI: 2.33–3.17) per LCRS unit and 1.13 (95% CI: 1.06–1.21) per GRS unit, and there was a significant joint association for high tertiles of the GRS and LCRS as compared to low tertiles. According to those authors, improvements in a lifestyle can help prevent MI regardless of genetic predisposition [ 58 ].…”

Section: Modern Models Of Genetic Risk Calculators (2016–2020)mentioning

confidence: 99%

Genetic Risk Score for Coronary Heart Disease: Review

Semaev

Shakhtshneider

2020

JPM

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The present review deals with the stages of creation, methods of calculation, and the use of a genetic risk score for coronary heart disease in various populations. The concept of risk factors is generally recognized on the basis of the results of epidemiological studies in the 20th century; according to this concept, the high prevalence of diseases of the circulatory system is due to lifestyle characteristics and associated risk factors. An important and relevant task for the healthcare system is to identify the population segments most susceptible to cardiovascular diseases (CVDs). The level of individual risk of an unfavorable cardiovascular prognosis is determined by genetic factors in addition to lifestyle factors.

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“…Lifestyle factors, such as smoking, physical inactivity and alcohol consumption, all contribute independently to the risk of developing cardiovascular diseases, and composite lifestyle risk scores (LRS) have been used previously to assess the combined effect of multiple lifestyle factors on cardiovascular disease development (Abdullah Said, Verweij, & Van Der Harst, 2018;Lé vesque, Poirier, Despré s, & Almé ras, 2017;Sotos-Prieto, Baylin, Campos, Qi, & Mattei, 2016). However, when applying LRS methodology to large collaborative consortium settings, challenges arise as not all lifestyle components in the LRS are available in all participating cohorts and/or may not be measured using the same instrument.…”

Section: Introductionmentioning

confidence: 99%

Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions

Schwander²,

Brown

et al. 2021

Eur J Hum Genet

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Recent studies consider lifestyle risk score (LRS), an aggregation of multiple lifestyle exposures, in identifying association of gene-lifestyle interaction with disease traits. However, not all cohorts have data on all lifestyle factors, leading to increased heterogeneity in the environmental exposure in collaborative meta-analyses. We compared and evaluated four approaches (Naï ve, Safe, Complete and Moderator Approaches) to handle the missingness in LRS-stratified meta-analyses under various scenarios. Compared to "benchmark" results with all lifestyle factors available for all cohorts, the Complete Approach, which included only cohorts with all lifestyle components, was underpowered, and the Naï ve Approach, which utilized all available data and ignored the missingness, was slightly liberal. The Safe Approach, which used all data in LRS-exposed group and only included cohorts with all lifestyle factors available in the LRS-unexposed group, and the Moderator Approach, which handled missingness via moderator meta-regression, were both slightly conservative and yielded almost identical p-values. We also evaluated the performance of the Safe Approach under different scenarios. We observed that the larger the proportion of cohorts without missingness included, the more accurate the results compared to "benchmark" results. In conclusion, we generally recommend the Safe Approach to handle heterogeneity in the LRS based genome-wide interaction meta-analyses..

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Lifestyle Cardiovascular Risk Score, Genetic Risk Score, and Myocardial Infarction in Hispanic/Latino Adults Living in Costa Rica

Cited by 21 publications

References 47 publications

The effect of heparin prescription before primary PCI on long-term and short-term clinical and para clinical results and the mortality of patients with acute coronary syndrome

The effect of heparin prescription before primary PCI on long-term and short-term clinical and para clinical results and the mortality of patients with acute coronary syndrome

Genetic Risk Score for Coronary Heart Disease: Review

Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions

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