Lifestyle Behavior Pattern Is Associated with Different levels of Risk for Incident Dementia and Alzheimer's Disease: The Cache County Study

Norton, Maria C.; Dew, Jeffrey P.; Smith, H; Fauth, Elizabeth B.; Piercy, Kathleen W.; Breitner, John C.S.; Tschanz, JoAnn T.; Wengreen, Heidi J.; Welsh‐Bohmer, Kathleen A.

doi:10.1111/j.1532-5415.2011.03860.x

Cited by 72 publications

(57 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In [13], the authors model latent classes (behaviours) in dementia analysis, showing the approaches relevance and according to the authors, the sole study to do so for dementia. The analysis attempts to determine sub-behaviours across six domains: church-attendance; smoking; alcohol use; social interaction; and physical exercise.…”

Section: Related Researchmentioning

confidence: 99%

Variable interactions in risk factors for dementia

O'Donoghue

Roantree

McCarren

2016

2016 IEEE Tenth International Conference on Research Challenges in Information Science (RCIS)

View full text Add to dashboard Cite

Abstract-Current estimates predict 1 in 3 people born today will develop dementia, suggesting a major impact on future population health. As such, research needs to connect specialist clinicians, data scientists and the general public. The In-MINDD project seeks to address this through the provision of a Profiler, a socio-technical information system connecting all three groups. The public interact, providing raw data; data scientists develop and refine prediction algorithms; and clinicians use in-built services to inform decisions. Common across these groups are Risk Factors, used for dementia-free survival prediction. Risk interactions could greatly inform prediction but determining these interactions is a problem underpinned by massive numbers of possible combinations. Our research employs a machine learning approach to automatically select best performing hyperparameters for prediction and learns variable interactions in a non-linear survival-analysis paradigm. Demonstrating effectiveness, we evaluate this approach using longitudinal data with a relatively small sample size.

show abstract

Section: Related Researchmentioning

confidence: 99%

Variable interactions in risk factors for dementia

O'Donoghue

Roantree

McCarren

2016

2016 IEEE Tenth International Conference on Research Challenges in Information Science (RCIS)

View full text Add to dashboard Cite

show abstract

“…Despite this suggestion, the results from Gregory et al call to question the pivotal role of vascular risk management for the improvement of cognition and gait outcomes in older adults; cognition improved independent of changes in vascular health outcomes. It is important to note that other potential mediators could facilitate improvements in cognition improvements in cognition following exercise training, including changes in social interaction [8], depressive symptomatology [9], cortical volume [10] and potentially many others; however, the authors failed to investigate this relationship within their study. Furthermore, the authors chose to use a predictive cardiorespiratory fitness outcome measure to determine evaluate changes in cardiorespiratory fitness following the exercise intervention.…”

mentioning

confidence: 58%

Commentary on “Group-Based Exercise Combined with Dual-Task Training Improves Gait but not Vascular Health in Active Older Adults without Dementia” - Missed Opportunities for Mediation Analyses

Ma¹

2017

Int J Neurorehabilitation Eng

View full text Add to dashboard Cite

OMICS International Commentary AbstractThis commentary considers the implications of the findings related to the effect of a community-based, multiple modality and dual-task exercise training program in the Archives of Gerontology and Geriatrics. Findings from this study suggest that participants who performed the multiple modality and dual-task exercise intervention experienced greater improvements in global cognition, greater elevations in dual-task gait speed and dual-task step-length and greater reductions in dual-task stride time variability when compared to participants who did not perform the dual-task component of the exercise training program. The ability of exercise to impart cognitive and other physiological benefits has been long understood; however, the mechanisms that facilitate these training-induced improvements remain elusive. Mediation analyses provide a unique avenue to investigate the relationship between various physiological measures and can provide insight related to the causal sequence that drives the beneficial physiological and psychological response to an intervention. Recent works have incorporated mediation analyses within their study designs and the insight provided therein has revealed a number of intriguing intricacies with respect to cognition in aging and the effect of exercise on the body and brain. Mediation analyses are rarely utilized in neurophysiological research; however, the complex phenomenological relationships that can be revealed using this method will be crucially required for the identification of factors responsible for improvements in cognition following pharmacological or lifestyle-based interventions, and the development of effective management strategies for older adults with cognitive impairment. This commentary considers the implications of the findings related to the effect of a community-based, multiple modality and dual-task exercise training program previously described by Gregory et al. [1] in the Archives of Gerontology and Geriatrics. The authors report that participants who performed the multiple modality and dual-task exercise intervention experienced greater elevations in dual-task gait speed and dual-task step-length and reductions in dual-task stride time variability when compared to participants who did not perform the dualtask component of the exercise training program. These results were secondary to the primary analysis concerning change in cognition postexercise training [2], which suggested that participants performing the multiple modality and dual-task exercise training program experienced greater elevations in global cognitive functioning when compared to those who performed the multiple modality exercise program alone; these improvements were driven by improvements in verbal learning and memory and verbal fluency scores. Commentary on "Group-BasedAlthough this study was a well-designed randomized controlled trial (RCT) that collected a number of physiological, psychological and behavioural outcomes, the primary limitation to the interpr...

show abstract

“…With one exception [8], the approximately 25 studies that so far have specifically investigated the association between alcohol consumption and dementia risk [9] include only individuals aged 65 years or older at the time of the alcohol consumption assessment [3,[10][11][12][13][14][15][16][17][18]. Hence, the findings are only generalisable to alcohol consumption close in time to dementia onset.…”

Section: Introductionmentioning

confidence: 76%

Alcohol Consumption and Risk of Dementia Up to 27 Years Later in a Large, Population-Based Sample: The Hunt Study, Norway

2015

The Gerontologist

View full text Add to dashboard Cite

The relationship between alcohol consumption and dementia risk is unclear. This investigation estimates the association between alcohol consumption reported in a population-based study in the mid-1980s and the risk for dementia up to 27 years later. The entire adult population in one Norwegian county was invited to the Nord-Trøn-delag Health Study during 1984-1986 (HUNT1): 88 % participated. The sample used in this study includes HUNT1 participants born between 1905 and 1946 who completed the questionnaire assessing alcohol consumption. A total of 40,435 individuals, of whom 1084 have developed dementia, are included in the analysis adjusted for age, sex, years of education, hypertension, obesity, smoking, and symptoms of depression. When adjusting for age and sex, and compared to reporting consumption of alcohol 1-4 times during the last 14 days (drinking infrequently), both abstaining from alcohol and reporting consumption of alcohol five or more times (drinking frequently) were statistically significantly associated with increased dementia risk with hazard ratios of 1.30 (95 % CI 1.05-1.61) and 1.45 (1.11-1.90), respectively. In the fully adjusted analysis, drinking alcohol frequently was still significantly associated with increased dementia risk with a hazard ratio of 1.40 (1.07-1.84). However, the association between dementia and abstaining from alcohol was no longer significant (1.15, 0.92-1.43). Equivalent results for Alzheimer's disease and vascular dementia indicated the same patterns of associations. When adjusting for other factors associated with dementia, frequent alcohol drinking, but not abstaining from alcohol, is associated with increased dementia risk compared to drinking alcohol infrequently.

show abstract

Lifestyle Behavior Pattern Is Associated with Different levels of Risk for Incident Dementia and Alzheimer's Disease: The Cache County Study

Cited by 72 publications

References 42 publications

Variable interactions in risk factors for dementia

Variable interactions in risk factors for dementia

Commentary on “Group-Based Exercise Combined with Dual-Task Training Improves Gait but not Vascular Health in Active Older Adults without Dementia” - Missed Opportunities for Mediation Analyses

Alcohol Consumption and Risk of Dementia Up to 27 Years Later in a Large, Population-Based Sample: The Hunt Study, Norway

Contact Info

Product

Resources

About