Lifestyle and vitamin D dosage in women with breast cancer

Abstract

Key words:Breast cancer. Vitamin D. Menopause. Physical activity. Case-control study. Palabras clave:Cáncer de mama. Vitamina D. Menopausia. Actividad física. Estudio de casos y controles. ResumenIntroducción: la estrategia de prevención del cáncer de mama sigue siendo el factor clave para el diagnóstico precoz y el método más efi caz para el seguimiento de la enfermedad. Objetivo: este estudio tuvo como objetivo evaluar el nivel de vitamina D asociado con el cáncer de mama en las mujeres. Métodos: este estudio de casos y controles hospitalarios se llevó a cabo con 181 mujeres con cáncer de mama y 197 controles sanas. Se estudió el nivel de vitamina D, calcio, fósforo y la dosis de suero PTH; se recopilaron de datos relacionados con el estilo de vida y com la historia de las pacientes, además se realizaron mediciones antropométricas. El análisis univariante (Chi-cuadrado probabilidades y primas ratio) y el análisis multivariado se realizó mediante regresión logística multivariante. Resultados: este estudio muestra un valor más alto de vitamina D en los controles de salud (26,9 mg/dl) que en las mujeres con cáncer de mama (24,8 mg/dl). Se encontraron más mujeres con sufi ciente vitamina D (34,85%) en el grupo control que en el grupo de cáncer. Usando el modelo de regresión logística múltiple, la historia familiar de cáncer de mama (OR 36,37; IC del 95%: 4,75 a 278,50) y la menopausia (OR 5,17; IC del 95%: 2,72 a 9,80) se halló una relación directa con el cáncer de mama, mientras que el nivel de vitamina D (OR 0,95; IC del 95%: 0,91 a 0,99) y la actividad física moderada (OR 0,31; IC del 95%: 0,10 a 0,93) mantienen las asociaciones inversas con la enfermedad. Conclusión: el estado de vitamina D y la práctica de actividad física moderada se consideraron factores de protección para el cáncer de mama. Sin embargo, la menopausia y la historia familiar de cáncer de mama se consideran un factor de riesgo para el cáncer de mama. AbstractIntroduction: The prevention strategy of breast cancer is still the key factor for early diagnosis and the most effective method for tracking the disease.Objective: This study aimed to evaluate the association vitamin D level with breast cancer in women.Methods: This hospital case-control study was conducted with 181 women with breast cancer and 197 healthy controls. Vitamin D status, calcium, phosphorus and PTH serum dosage and data collection related to lifestyle and patient's history, besides anthropometric measurements were performed. Univariate analysis (Chi-square and raw odds ratio) and multivariate analysis were performed through multivariate logistic regression. Results: This study shows a higher value of vitamin D in health controls (26.9 mg/dL) than in breast cancer women (24.8 mg/dL). Higher numbers of women with suffi cient vitamin D status (34.85%) were found in control group than cancer group. Using the multiple logistic regression model, the family history of breast cancer (OR 36.37,) and menopause (OR 5.17, 95% CI 2.72-9.80) had a direct association with breast cancer, wh...

Association between Serum 25-hydroxy Vitamin D Concentration and TaqI Vitamin D Receptor Gene Polymorphism among Jordanian Females with Breast Cancer

“…[67] Vitamin D status and the practice of moderate physical activity were considered protective factors for breast cancer. [8] Vitamin D supplementation, mostly taken daily and combined with calcium, was associated with a decreased postmenopausal breast cancer risk in menopausal hormone therapy users. [9] Experimental and clinical observations suggest that Vitamin D and its analogs might be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer.…”

Low Levels of Vitamin D in a Cohort of Women with Impalpable Breast Lesions from Rio de Janeiro/Brazil

“…The low levels of Vitamin D herein presented for the control group, as well as for the other studies (Oliveira et al, 2016;Bilinski et al, 2013;Unger et al, 2010), are alarming. These values become more evident in countries whose sun incidence is low or that have periods of rigorous winter (Nouri et al, 2017;Shirazi et al, 2016).…”

“…In view of these findings, vitamin D-binding protein should be validated as a putative biomarker in a future study. With regard to the Brazilian population, two reports evaluated breast cancer and vitamin D deficiency (de Lyra et al, 2006;Oliveira et al, 2016). Lyra (2006) studied the levels of 1,25(OH)2D3 and 25OHD in 88 women with breast cancer and 35 controls (submitted to mammoplasties or resection of benign lesions) in the city of São Paulo.…”

“…These results were similar to those of our study, in which no significant difference was detected for the different degrees of tumors (P=0.102) and lymph node involvement (P=1.00). On the other hand, the second Brazilian study, conducted in Belo Horizonte city, evaluating 181 women with breast cancer and 197 controls, determined that the levels of vitamin D sufficiency (P=0.012) and the moderate practice of physical activity (P=0.037) were protective variables for breast cancer (Oliveira et al, 2016).…”

Homeopathy and Complementary Integrative Medicine, Dietary and Lifestyle Advices to Reduce Adverse-Effects of Anti-Cancer Therapy: A Cohort Study with Breast Cancer Patients

“…The blood levels of vitamin D were checked for all the patients and if necessary, an integration of this vitamin in the current treatment was proposed, until the correct level was achieved [18,19].…”