Lifestyle and gastric cancer: a case-control study.

Watabe, Kosho; Nishi, Motoi; Miyake, Hirotsugu; Hirata, Koichi

doi:10.3892/or.5.5.1191

Cited by 54 publications

(64 citation statements)

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“…However, PA assessment was restricted to calculate the amount of hours per week spent on low, medium and high intensity leisure and work activities. In a similar line, Watabe et al [51], who found no evidence of PA as a risk factor, only informed about the relationship between recreational activity and stomach cancer, whereas in other studies, some degree of association between the performance of PA and the risk of gastric cancer was observed, but again only the recreational type was measured [11,43]. Finally, in the Whitehall study [4], a protective effect of travel activity on stomach cancer was found among men, but no other type of PA was measured.…”

Section: Selecting Pa Domainssupporting

confidence: 60%

Methodological issues when analysing the role of physical activity in gastric cancer prevention: a critical review

Ayán

Molina

Fernández

et al. 2012

Eur Rev Aging Phys Act

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The beneficial effect of physical activity (PA) has been confirmed in several types of cancer (especially colon and breast tumours). However, the role of PA as a risk factor directly related to the incidence of gastric cancer is still open to doubt. This is in part due to the fact that most studies have not considered gastric sub-site or histology of oesophageal cancer, as well as the different approaches used in order to measure PA. Indeed, some studies have tried to link gastric cancer to PA intensity and timing, whereas others have focused on a specific PA type such as recreational, occupational or sporting activity. Furthermore, most of them do not use validated questionnaires, and others create a PA index and employ different unit measures (metabolic equivalents, hours/week, times per week, etc.), which makes it difficult to compare its findings. Under these circumstances, this brief critical review aims to explore and show all the methodological issues that need to be taken into account in order to objectify the link between PA and gastric cancer, as well as provide alternative solutions to these matters.

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Section: Selecting Pa Domainssupporting

confidence: 60%

Methodological issues when analysing the role of physical activity in gastric cancer prevention: a critical review

Ayán

Molina

Fernández

et al. 2012

Eur Rev Aging Phys Act

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“…The coefficient of agreement between the two reviewers for study selection was very good (Cohen k ¼ 0.78). Three studies reported the association between physical activity and mortality from gastric cancer and were excluded (35)(36)(37). There were two studies from the same Japan-Hawaii Cancer Study cohort (33,38) and hence, only the most comprehensive report from these was included (33).…”

Section: Resultsmentioning

confidence: 99%

Physical Activity Is Associated with Reduced Risk of Gastric Cancer: A Systematic Review and Meta-analysis

Singh

Varayil

Devanna

et al. 2014

Cancer Prevention Research

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Physical activity may be associated with reduced risk of gastric cancer. We performed a systematic review and meta-analysis to evaluate the magnitude of the association and the quality of supporting evidence. After a comprehensive search of bibliographic databases and conference proceedings through February 2013 for observational studies that examined associations between recreational and/or occupational physical activity and gastric cancer risk, we identified 16 studies (seven cohort, nine case control) reporting 11,111 cases of gastric cancer among 1,606,760 patients. Summary adjusted-OR estimates with 95% confidence intervals (CI) were estimated using the random-effects model. Meta-analysis demonstrated that the risk of gastric cancer was 21% lower among the most physically active people as compared with the least physically active people (OR ¼ 0.79; 95% CI, 0.71-0.87) with moderate heterogeneity among studies (I 2 ¼ 55%). This protective effect was seen for gastric cancers in the cardia (four studies; OR ¼ 0.80; 95% CI, 0.63-1.00) and distal stomach (five studies; OR ¼ 0.63; 95% CI, 0.52-0.76). The effect size was significantly smaller in highquality studies (six studies; OR ¼ 0.86; 95% CI, 0.75-0.99), as compared with low-quality studies (10 studies; OR ¼ 0.74; 95% CI, 0.69-0.81). The results were consistent across sex, study quality, study design, and geographic location. In conclusion, meta-analysis of published observational studies indicates that physical activity is associated with reduced risk of gastric cancer. Lifestyle interventions focusing on increasing physical activity may decrease the global burden of gastric cancer, in addition to a myriad of other health benefits. Cancer Prev Res; 7(1); 12-22. Ó2013 AACR.

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“…Several epidemiological studies suggested that psychological stress factors may accelerate the progression of gastric cancer (38,39). The association of psychological stress with gastrointestinal symptoms has long been noticed (40).…”

Section: Discussionmentioning

confidence: 99%

Catecholamine-Induced β2-Adrenergic Receptor Activation Mediates Desensitization of Gastric Cancer Cells to Trastuzumab by Upregulating MUC4 Expression

Shi¹,

Yang

Hu³

et al. 2013

The Journal of Immunology

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Trastuzumab is currently used for patients with Her2+ advanced gastric cancer. However, the response rate to trastuzumab among the patients is low. The molecular mechanisms underlying trastuzumab resistance in gastric cancer are unknown. Our in vitro data show that activation of β2-adrenergic receptor (β2-AR) triggered by catecholamine caused “targeting failure” of trastuzumab in gastric cancer cells. The antitumor activities of trastuzumab were significantly impeded by chronic catecholamine stimulation in gastric cancer cells and in the mice bearing human gastric cancer xenografts. Mechanistically, catecholamine induced upregulation of the MUC4 expression at both transcription and protein levels via activating STAT3 and ERK. The effects of catecholamine could be effectively blocked by β2-AR antagonist ICI-118,551, indicating that β2-AR–mediated signaling pathway plays a key role in upregulation of MUC4, which was previously demonstrated to interfere with the recognition and physical binding of trastuzumab to Her2 molecules. Moreover, a significant elevation of the MUC4 level was observed in the xenograft tissues in nude mice chronically treated with isoproterenol. Knockdown of MUC4 restored the binding activities of trastuzumab to Her2-overexpressing gastric cancer cells. In addition, coexpression of β2-AR and MUC4 were observed in gastric cancer tissues. Our data indicated a novel trastuzumab resistance mechanism, by which catecholamine-induced β2-AR activation mediates desensitization of gastric cancer cells to trastuzumab through upregulating the MUC4 expression.

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Lifestyle and gastric cancer: a case-control study.

Cited by 54 publications

References 0 publications

Methodological issues when analysing the role of physical activity in gastric cancer prevention: a critical review

Methodological issues when analysing the role of physical activity in gastric cancer prevention: a critical review

Physical Activity Is Associated with Reduced Risk of Gastric Cancer: A Systematic Review and Meta-analysis

Catecholamine-Induced β2-Adrenergic Receptor Activation Mediates Desensitization of Gastric Cancer Cells to Trastuzumab by Upregulating MUC4 Expression

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