Lifelong corticosterone level determines age-related decline in neurogenesis and memory

Montaron, Marie-Françoise; Drapeau, Elodie; Dupret, David; Kitchener, Pierre; Aurousseau, C.; Moal, Michel Le; Piazza, Pier Vincenzo; Abrous, Djoher Nora

doi:10.1016/j.neurobiolaging.2005.02.014

Cited by 180 publications

(140 citation statements)

References 43 publications

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“…This observation is consistent with previous studies (e.g., Cano et al 2008;Cizza et al 1994), although inconsistent with others (e.g., Bizon et al 2001;Montaron et al 2006;Workel et al 2001). Among factors that could account for the discrepant findings, the time of the light-dark cycle at which the samples were collected may be of major relevance (Cano et al 2008).…”

Section: Basal Corticosterone Levelssupporting

confidence: 80%

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Harati

Barbelivien

Herbeaux

et al. 2012

AGE

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We assessed lifelong environmental enrichment effects on possible age-related modifications in emotional behaviors, spatial memory acquisition, retrieval of recent and remote spatial memory, and cholinergic forebrain systems. At the age of 1 month, Long-Evans female rats were placed in standard or enriched rearing conditions and tested after 3 (young), 12 (middle-aged), or 24 (aged)months. Environmental enrichment decreased the reactivity to stressful situations regardless of age. In the water maze test, it delayed the onset of learning deficits and prevented age-dependent spatial learning and recent memory retrieval alterations. Remote memory retrieval, which was altered independently of age under standard rearing conditions, was rescued by enrichment in young and middle-aged, but unfortunately not aged rats. A protected basal forebrain cholinergic system, which could well be one out of several neuronal manifestations of lifelong environmental enrichment, might have contributed to the behavioral benefits of this enrichment.

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Section: Basal Corticosterone Levelssupporting

confidence: 80%

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Harati

Barbelivien

Herbeaux

et al. 2012

AGE

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“…Nevertheless, the rat does not show the gross changes in white matter that humans undergo with age. On a speculative note, it is possible that the controlled experiences of laboratory rats have eliminated two critical factors that have been shown to impact aging: stress and immune challenges across the lifespan (Lupien et al, 1998;Brunson et al, 2005;Sandi & Touyarot, 2006;Montaron et al, 2006;Godbout & Johnson, 2006). Why the corpus callosum of the laboratory rat does not age as readily as the human may be worth exploring to better understand the course of human aging.…”

Section: Discussionmentioning

confidence: 99%

Increases in size and myelination of the rat corpus callosum during adulthood are maintained into old age

Yates

Juraska

2007

Brain Research

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Although there are indications of growth in the size and myelination of the rat corpus callosum during adulthood, it is not known how long this growth continues. In addition, the potential for age-related changes in these measures to affect the sex differences seen in adulthood has not been examined. Here the size of callosal subregions and area occupied by myelin were examined in the genu and splenium of male and female rats in adulthood, middle-age, and old age. Our findings revealed increases both in size and in the area composed of myelin between adulthood and middle-age that were maintained into old age, with no indications of age-related loss in either the genu or splenium of the rat.

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“…Interestingly, two hours after ACTH treatment, plasma corticosterone levels were relatively elevated in old rats compared to young mature rats. Montaron et al, [474] reported an age-related increase in basal plasma corticosterone levels [i.e., young (3-mo) or young mature (14-mo) vs old (21-26-mo). However, no aging effect on plasma corticosterone levels was detected when animals were subjected to restraint stress.…”

Section: Long-evans (Le) Ratsmentioning

confidence: 99%

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Zaidi¹

2013

TOLSJ

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Steroid hormones are lipophilic, low-molecular weight organic compounds all of which are derived from cholesterol. They are primarily synthesized by steroidogenic glands such as gonads (ovary and testis), the adrenal gland and, during pregnancy, by the placental trophoblasts. Limited steroid synthesis also takes place in the brain. Steroid hormones are crucial for the proper functioning of the body. They mediate a wide variety of vital physiological functions, ranging from maintaining normal reproductive function and secondary sexual characteristics, to regulating virtually every metabolic process in the body. Like many age-related endocrine disorders, aging also progressively impacts the tissue-specific synthesis and secretion of steroid hormones. The goal of this review is to summarize the effects of aging on steroid hormone synthesis and secretion by the adrenal gland and gonads of both human and experimental animal models, to describe the potential involvement of excessive oxidative stress in mediating age-related alterations in steroidogenesis, and to discuss the possible underlying mechanisms involved.

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Lifelong corticosterone level determines age-related decline in neurogenesis and memory

Cited by 180 publications

References 43 publications

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Increases in size and myelination of the rat corpus callosum during adulthood are maintained into old age

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

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