Life with the pancreas: A personal experience

Morisset, Jean

doi:10.1016/j.advms.2019.11.002

Cited by 3 publications

(2 citation statements)

References 151 publications

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“…Alongside with the chemical differences in GIT, in our work, the BEO animals had heavier pancreas and intestines, and higher ileum villus height, indicating that supplemented animals could have a better GIT function and nutrient digestibility. A heavier pancreas indicates increased activity in this organ with a higher production of enzymes and a more active metabolism 53 . It is known that diet can cause an effect on pancreas development and function 54 , as well as an impact on the GIT microbiota and consequently this organ function 55 .…”

Section: Discussionmentioning

confidence: 99%

Potential benefits of a blend of essential oils on metabolism, digestibility, organ development and gene expression of dairy calves

Campolina

Coelho²,

Belli³

et al. 2023

Sci Rep

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The objective of this study was to evaluate blood cells and metabolites, insulin-like growth factor-1 (IGF-1), digestibility, internal organs weight and histology, gene expression, and spleen cell proliferation of pre-weaned bull calves supplemented with a blend of essential oils in milk replacer (MR). Sixteen newborn Holstein × Gyr crossbred dairy bull calves, with body weight at birth of 33.3 ± 3.7 kg, were housed in individual sand bedded pens, blocked by genetic composition, and randomly assigned to 1 of 2 treatments in a randomized complete block design: Control (CON, n = 8) and blend of essential oils supplementation (BEO, n = 8, 1 g/day/calf, Apex Calf, Adisseo, China). The commercial blend was composed by plant extracts derived from anise, cinnamon, garlic, rosemary, and thyme. Animals were fed 5 L of MR/day reconstituted at 15% (dry matter basis), divided into two equal meals. Water and starter were provided ad libitum. ß-hydroxybutyrate, urea, and glucose were evaluated weekly, IGF-1 was evaluated biweekly, and total blood cell count was performed every four weeks until the end of the trial at eight weeks of age. Feed samples were collected three times a week and polled for weekly analysis. Apparent total nutrient digestibility was determined from d 56 to 60 of age. On d 60 ± 1, animals were euthanized for organ weight, histology, spleen cell proliferation, and intestinal gene expression analysis. Data were analyzed independently using linear mixed models using the REML method in the nlme package in R for continuous outcomes. A non-parametric test was used for ordered categorical outcomes using the Artools package in R. There were no differences between groups for blood evaluations, digestibility, gene expression, and a spleen cell proliferation assay. However, BEO calves presented a heavier pancreas, heavier intestines, bigger ileum villi, and higher cecum butyrate levels (P < 0.05), demonstrating that the EO supplementation helped intestinal development and symbiotic bacteria. It was also observed in CON animals’ heavier respiratory tract and a higher eosinophil count (P < 0.05). Therefore, the organs where eosinophils are more active had a better response for BEO animals. No differences were found in the intestinal gene expression in the immune context. These results demonstrate that supplementing essential oils in MR could contribute to gut development and immune function. However, more research is needed to understand its impact on body development and define the best dosage and route of administration.

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Section: Discussionmentioning

confidence: 99%

Potential benefits of a blend of essential oils on metabolism, digestibility, organ development and gene expression of dairy calves

Campolina

Coelho²,

Belli³

et al. 2023

Sci Rep

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“…The central nervous system and hormones regulate the exocrine function of the pancreas. Hormones such as secretin and cholecystokinin (CCK) are believed to be the main intestinal hormones that regulate the secretion of pancreatic digestive enzymes ( Morisset, 2020 ). Secretin is released from enteroendocrine cells in the small intestine, and CCK is released from the duodenum and jejunum in the presence of lipids and proteins from ingested food.…”

Section: Influence Of the Exocrine Function Of The Pancreas On The De...mentioning

confidence: 99%

Pancreas—Its Functions, Disorders, and Physiological Impact on the Mammals’ Organism

Karpińska

Czauderna

2022

Front. Physiol.

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This review aimed to analyze the scientific literature on pancreatic diseases (especially exocrine pancreatic insufficiency). This review also describes the correlation between the physiological fitness of the pancreas and obesity. The influence of the pancreatic exocrine function on the development of the organism of adults and adolescents was also described. The results of piglet studies available in the literature were cited as an established model used to optimize treatments for pancreatic diseases in humans. The pancreas has an exocrine and hormonal function. Consequently, it is one of the key internal organs in animals and humans. Pancreatic diseases are usually severe and particularly troublesome. A properly composed diet and taken dietary supplements significantly improve the patient’s well-being, as well as the course of the disease. Therefore, a diet and a healthy lifestyle positively affect maintaining the optimal physiological efficiency of the pancreas.

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Professor Jean Morisset - 50 years of dedicated research on the Pancreas

Barreto

2020

Pancreatology

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Life with the pancreas: A personal experience

Cited by 3 publications

References 151 publications

Potential benefits of a blend of essential oils on metabolism, digestibility, organ development and gene expression of dairy calves

Potential benefits of a blend of essential oils on metabolism, digestibility, organ development and gene expression of dairy calves

Pancreas—Its Functions, Disorders, and Physiological Impact on the Mammals’ Organism

Professor Jean Morisset - 50 years of dedicated research on the Pancreas

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