Life-threatening secondary hemophagocytic lymphohistiocytosis following vagal nerve stimulator infection in a child with CHD2 myoclonic encephalopathy: a case report

Parisi, Cristiano; Candela-Cantó, Santiago; Serrano, Mercedes; Catalá, Albert; Aparicio, Javier Romano; Hinojosa, J.

doi:10.1007/s00381-020-04558-x

Cited by 3 publications

(1 citation statement)

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“…The brainstem and midline thalamus of NER were activated after acute and chronic VNS (7). VNS was also effective in the epileptic baboon, a naturally occurring animal model for genetic generalized epilepsy (GGE) (8).…”

Section: Discussionmentioning

confidence: 99%

Refractory Status Epilepticus in Genetic Epilepsy—Is Vagus Nerve Stimulation an Option?

et al. 2020

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Refractory and super-refractory status epilepticus (RSE, SRSE) are severe conditions that can have long-term neurological consequences with high morbidity and mortality rates. The usefulness of vagus nerve-stimulation (VNS) implantation during RSE has been documented by anecdotal cases and in systematic reviews; however, the use of VNS in RSE has not been widely adopted. We successfully implanted VNS in two patients with genetic epilepsy admitted to hospital for SRSE; detailed descriptions of the clinical findings and VNS parameters are provided. Our patients were implanted 25 and 58 days after status epilepticus (SE) onset, and a stable remission of SE was observed from the seventh and tenth day after VNS implantation, respectively, without change in anti-seizure medication. We used a fast ramp-up of stimulation without evident side effects. Our results support the consideration of VNS implantation as a safe and effective adjunctive treatment for SRSE.

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Section: Discussionmentioning

confidence: 99%