“…5 Interestingly, there is a case report in which a patient experienced severe intrapleural bleeding with opacification of a hemithorax after receiving intrapleural tPA/ DNase while fully anticoagulated. 6 This suggests that bleeding risk may be increased using this combination. Our case suggests but does not prove that similar complications can occur during intrapleural tPA/DNase administration when DVT prophylaxis with an anticoagulant is used.…”