Life-threatening pediatric dextromethorphan polistirex overdose

Seltzer, Justin; Sheth, Sarika K.; Friedland, Sarah; Foreman, Emily; Toney, Caitlin; Raviendran, Raveen; McDaniel, Michele; Lasoff, Daniel

doi:10.1016/j.ajem.2022.08.006

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Concurrent use of dextromethorphan with substances that inhibit CYP2D6 can further prolong its elimination half-life. 76 , 77 Fortunately, due to the relatively short elimination time of both drugs, most toxic effects can be managed with supportive care.…”

Section: Case Reportmentioning

confidence: 99%

Clinical Toxicology of OTC Cough and Cold Pediatric Medications: A Narrative Review

Diantini,

Alfaqeeh,

Permatasari

et al. 2024

PHMT

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Section: Case Reportmentioning

confidence: 99%

Clinical Toxicology of OTC Cough and Cold Pediatric Medications: A Narrative Review

Diantini,

Alfaqeeh,

Permatasari

et al. 2024

PHMT

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“…More broadly, there have been many instances involving mild symptoms; only a small fraction of these reports are for severe cases that necessitated intensive care[ 13 ]. We presented the case of a female who ingested 111 tablets of dextromethorphan of Chinese origin, leading to shock and convulsions.…”

Section: Introductionmentioning

confidence: 99%

High doses of dextromethorphan induced shock and convulsions in a 19-year-old female: A case report

Shimozawa¹,

Usuda²,

Sasaki³

et al. 2023

World J Clin Cases

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BACKGROUND Dextromethorphan is a prevalent antitussive agent that can be easily obtained as an over-the-counter medication. There has been a growing number of reported cases of toxicity in recent years. Generally, there are numerous instances of mild symptoms, with only a limited number of reports of severe cases necessitating intensive care. We presented the case of a female who ingested 111 tablets of dextromethorphan, leading to shock and convulsions and requiring intensive care that ultimately saved her life. CASE SUMMARY A 19-year-old female was admitted to our hospital via ambulance, having overdosed on 111 tablets of dextromethorphan (15 mg) obtained through an online importer in a suicide attempt. The patient had a history of drug abuse and multiple self-inflicted injuries. At the time of admission, she exhibited symptoms of shock and altered consciousness. However, upon arrival at the hospital, the patient experienced recurrent generalized clonic convulsions and status epilepticus, necessitating tracheal intubation. The convulsions were determined to have been caused by decreased cerebral perfusion pressure secondary to shock, and noradrenaline was administered as a vasopressor. Gastric lavage and activated charcoal were also administered after intubation. Through systemic management in the intensive care unit, the patient’s condition stabilized, and the need for vasopressors ceased. The patient regained consciousness and was extubated. The patient was subsequently transferred to a psychiatric facility, as suicidal ideation persisted. CONCLUSION We report the first case of shock caused by an overdose of dextromethorphan.

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Dextromethorphan overdose

2022

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Life-threatening pediatric dextromethorphan polistirex overdose

Cited by 3 publications

References 6 publications

Clinical Toxicology of OTC Cough and Cold Pediatric Medications: A Narrative Review

Clinical Toxicology of OTC Cough and Cold Pediatric Medications: A Narrative Review

High doses of dextromethorphan induced shock and convulsions in a 19-year-old female: A case report

Dextromethorphan overdose

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