Life-Threatening Infection in Transplant Recipients

O'Shea, Dàire; Humar, Atul

doi:10.1016/j.ccc.2013.06.012

Cited by 16 publications

(9 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, immunosuppressive antirejection drugs that are commonly prescribed to transplant recipients, like tacrolimus, sirolimus, and cyclosporins, suppress the Th1 arm of the immune response by preventing the activation of T cells. In an immunocompromised state, these patients tend to suffer from a myriad of different opportunistic infections that can be parasitic (57), fungal (58), bacterial (58), and viral (59) in origin. More recently, it has come to light that sirolimus, but not tacrolimus, inhibits B cell differentiation into antibody-producing plasma cells (60,61).…”

Section: Increased Susceptibility To Rsv Infection Due To Pharmacologmentioning

confidence: 99%

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment

2017

View full text Add to dashboard Cite

SUMMARY Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children in North America and one of the leading causes of death of infants less than 1 year of age worldwide, second only to malaria. Despite its global impact on human health, there are relatively few therapeutic options available to prevent or treat RSV infection. Paradoxically, there is a very large volume of information that is constantly being refined on RSV replication, the mechanisms of RSV-induced pathology, and community transmission. Compounding the burden of acute RSV infections is the exacerbation of preexisting chronic airway diseases and the chronic sequelae of RSV infection. A mechanistic link is even starting to emerge between asthma and those who suffer severe RSV infection early in childhood. In this article, we discuss developments in the understanding of RSV replication, pathogenesis, diagnostics, and therapeutics. We attempt to reconcile the large body of information on RSV and why after many clinical trials there is still no efficacious RSV vaccine and few therapeutics.

show abstract

Section: Increased Susceptibility To Rsv Infection Due To Pharmacologmentioning

confidence: 99%

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment

2017

View full text Add to dashboard Cite

show abstract

“…72 Liver, pancreas, and intestinal recipients are at particular risk for fungal infections, most often caused by Candida species. 41,74,75 Regarding DDLT versus LDLT, there are variations with infectious complications. The rate of infection appears to be similar to DDLT; however, because of the more complex nature of the surgery, there are observable difference and specific concerns as detailed in Box 1.…”

Section: Hepatobiliary Infectionsmentioning

confidence: 99%

“…89,92 Relapsing disease is common, and protracted courses of therapy are often essential. 74,93,94 IDSA and Society for Healthcare Epidemiology of America recently updated the Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children for 2017, and although this is for immunocompetent patients, these guidelines can be applied to SOT recipients because there have been limited studies into the treatment of CDI in SOT patients.…”

Section: Enterocolitismentioning

confidence: 99%

Infectious Complications Following Solid Organ Transplantation

Guenette

Husain

2019

Critical Care Clinics

View full text Add to dashboard Cite

KEYWORDSInfections Solid organ transplant Critical care Intensive care unit (ICU) Sepsis KEY POINTSSolid organ transplant recipients are a complex group of patients who require a low threshold of suspicion regarding infection, and given their underlying immunosuppression, mortality and morbidity are high. Individually they require assessment of their net state of immunosuppression and subsequent thorough evaluation of infectious causes. Early diagnosis is key along with appropriate, tailored treatment.Crit Care Clin 35 (2019) 151-168

show abstract

“…With the exception of bacterial infections, prophylaxis is typically given for high risk infections. Adapted from O'Shea and Humar, .…”

Section: Immunosuppression and Relationship To Infectious Diseasementioning

confidence: 99%

Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment

et al. 2016

View full text Add to dashboard Cite

This overview is an update of the unit originally published in 2004. While the basic tenants of immunotoxicity have not changed in the past 10 years, several publications have explored the application of immunotoxicological data to the risk assessment process. Therefore, the goal of this unit is still to highlight relationships between xenobiotic-induced immunosuppression and risk of clinical diseases progression. In immunotoxicology, this may require development of models to equate moderate changes in markers of immune functions to potential changes in incidence or severity of infectious diseases. For most xenobiotics, exposure levels and disease incidence data are rarely available and safe exposure levels must be estimated based on observations from experimental models or human biomarker studies. Thus, it is important to establish a scientifically sound framework that allows accurate and quantitative interpretation of experimental or biomarker data in the risk assessment process.

show abstract

Life-Threatening Infection in Transplant Recipients

Cited by 16 publications

References 109 publications

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment

Infectious Complications Following Solid Organ Transplantation

Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment

Contact Info

Product

Resources

About