Life-Threatening Hyponatremia Following a Low-Iodine Diet: A Case Report and Review of all Reported Cases

Nozha, Omar M. Al; Vautour, Line; How, Jacques

doi:10.4158/ep11045.cr

Cited by 18 publications

(25 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In one case report, a 66 year old female patient visited the emergency room and had serum sodium level of 107 mEq/L after low-iodine diet for thyroid ablation, and the author suggested that prolonged low-iodine diet, low salt intake, and use of thiazide diuretics in elderly patients were risk factors for the development of life-threatening hyponatremia [8]. As can be seen in previous case reports [6]–[10], most of the patients were above 60 years of age and all of the patients showed quite severe hyponatremia with serum sodium levels ranging from 107 mEq/L to 121 mEq/L.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Developing Hyponatremia in Thyroid Cancer Patients Undergoing Radioactive Iodine Therapy

et al. 2014

View full text Add to dashboard Cite

BackgroundDue to the alarming increase in the incidence of thyroid cancer worldwide, more patients are receiving postoperative radioactive iodine (RAI) therapy and these patients are given a low-iodine diet along with levothyroxine withdrawal to induce a hypothyroid state to maximize the uptake of RAI by thyroid tissues. Recently, the reported cases of patients suffering from life-threatening severe hyponatremia following postoperative RAI therapy have increased. This study aimed to systematically assess risk factors for developing hyponatremia following RAI therapy in post-thyroidectomy patients.MethodsWe reviewed the medical records of all thyroid cancer patients who underwent thyroidectomy and postoperative RAI therapy from July 2009 to February 2012. Demographic and biochemical parameters including serum sodium and thyroid function tests were assessed along with medication history.ResultsA total of 2229 patients (47.0±11.0 years, female 76.3%) were enrolled in the analysis. Three hundred seven patients (13.8%) of all patients developed hyponatremia; 44 patients (2.0%) developed moderate to severe hyponatremia (serum Na+≤130 mEq/L) and another 263 (11.8%) patients showed mild hyponatremia (130 mEq/L

show abstract

Section: Discussionmentioning

confidence: 99%

Risk Factors for Developing Hyponatremia in Thyroid Cancer Patients Undergoing Radioactive Iodine Therapy

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Inducing distinctive hypothyroidism with thyroid hormone withdrawal and a low-iodine diet is an essential condition for accurate examination. However, there is a possibility that related complications can occur [3,4,5,6,11]. …”

Section: Discussionmentioning

confidence: 99%

“…However, it is rare to find severe hyponatremia related to hypothyroidism caused by thyroid hormone withdrawal in a patient with thyroid cancer [3,4,5,6,7]. Baajafer et al [7] reported that there were no complications by hypothyroid status induced by thyroid hormone withdrawal among 128 patients who underwent surgery with differentiated thyroid cancer, only five of them were presenting hyponatremia with a serum sodium level of 135 mEg/L and no cases were witnessed with a serum sodium level lower than 130 mEq/L.…”

Section: Discussionmentioning

confidence: 99%

“…There are case reports of severe symptomatic hyponatremia being induced by a low-iodine diet as pretreatment before radioiodine remnant ablation and iodine whole-body scanning [3,4,5,6]. In two out of nine cases, recombinant human thyrotropin (rhTSH) was alternatively infused instead of thyroid hormone withdrawal, and in seven cases thyroid hormone administration was ceased.…”

Section: Discussionmentioning

confidence: 99%

“…Hypothyroidism is a cause of hyponatremia, but severe hyponatremia associated with hypothyroidism induced by thyroid hormone withdrawal from a patient with thyroid cancer is only rarely observed [3,4,5,6,7]. Here, the authors report a case of severe hyponatremia following thyroid hormone withdrawal prior to iodine whole-body scanning in a patient with post thyroidectomy status of papillary thyroid cancer.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hyponatremia after Thyroid Hormone Withdrawal in a Patient with Papillary Thyroid Carcinoma

Kim

Shin

et al. 2014

Endocrinol Metab

View full text Add to dashboard Cite

Hyponatremia is an electrolyte abnormality commonly found in clinical practice. It is important to diagnose the underlying etiology of the hyponatremia and correct it appropriately because severe hyponatremia can cause serious complications and substantially increase the risk of mortality. Although hypothyroidism is known to be a cause of hyponatremia, it is rare that hyponatremia occurs in relation to hypothyroidism induced by thyroid hormone withdrawal in patients with differentiated thyroid cancer. We report a case of a 76-year-old woman with papillary thyroid carcinoma presenting with severe hyponatremia related to hypothyroidism induced by thyroid hormone withdrawal for radio-active iodine whole-body scanning, who was treated by thyroid hormone replacement and hydration. Considering that the incidence of differentiated thyroid cancer is rapidly increasing, physicians should be aware that, although uncommon, hyponatremia can occur in patients undergoing radioiodine therapy or diagnostic testing.

show abstract

Surveillance Strategies After Initial Treatment of Differentiated Thyroid Cancer

Kirk

2017

Management of Differentiated Thyroid Cancer

View full text Add to dashboard Cite

Life-Threatening Hyponatremia Following a Low-Iodine Diet: A Case Report and Review of all Reported Cases

Cited by 18 publications

References 15 publications

Risk Factors for Developing Hyponatremia in Thyroid Cancer Patients Undergoing Radioactive Iodine Therapy

Risk Factors for Developing Hyponatremia in Thyroid Cancer Patients Undergoing Radioactive Iodine Therapy

Hyponatremia after Thyroid Hormone Withdrawal in a Patient with Papillary Thyroid Carcinoma

Surveillance Strategies After Initial Treatment of Differentiated Thyroid Cancer

Contact Info

Product

Resources

About