Life-Threatening Human Metapneumovirus Pneumonia Requiring Extracorporeal Membrane Oxygenation in a Preterm Infant

Ulloa‐Gutiérrez, Rolando; Skippen, Peter; Synnes, Anne; Seear, Michael; Bastien, Nathalie; Li, Yan; Forbes, John C.

doi:10.1542/peds.2004-0345

Cited by 37 publications

(37 citation statements)

References 14 publications

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“…Peiris et al reported that the patients with hMPV tend to have a longer hospital stay of more than two days (28). Our results indicated that those infected with hMPV might have a longer duration of fever and hospitalization than those infected with RSV and influenza viruses (29).…”

Section: Discussionmentioning

confidence: 47%

The Prevalence of Human Metapneumovirus and Respiratory Syncytial Virus and Coinfection With Both in Hospitalized Children With Acute Respiratory Infection in South of Iran

Moattari

Aleyasin

Fyruzi

et al. 2015

Arch Pediatr Infect Dis

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Background: Viral infections are the most frequent causes of morbidity and mortality due to respiratory dysfunction worldwide, especially in children under five years of age. Several studies have reported the association of human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) with acute respiratory infection. Objectives: The present study aimed to investigate the prevalence of hMPV, RSV, and their coinfection in children with respiratory symptoms hospitalized in Shiraz City, Fars Province, Iran. The study also attempted to determine the association between asthma and wheezing with hMPV, RSV, and coinfection with both in studied children. Patients and Methods:The study included 280 younger than five years old children with non-influenza infection that were hospitalized for respiratory infection from 2011 to 2013. Nasopharyngeal swabs were collected from patients and tested for RSV and hMPV with reverse transcriptase polymerase chain reaction. Results: The hMPV and RSV were detected in 44 (15.7%) and 84 (30.0%) samples, respectively. Coinfection with both viruses was found in ten patients (3.57%). The incidence of hMPV and RSV infections were observed in children younger than one year old. Infections occurred predominantly from October to April. The most common clinical symptoms were bronchiolitis, wheezing, and cough. Conclusions: Infection with hMPV and RSV are most frequent infections among pediatric patients with respiratory tract symptoms. Coinfection with these viruses may exacerbate the clinical symptoms and increase hospitalization rates, especially in children younger than one year old.

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Section: Discussionmentioning

confidence: 47%

The Prevalence of Human Metapneumovirus and Respiratory Syncytial Virus and Coinfection With Both in Hospitalized Children With Acute Respiratory Infection in South of Iran

Moattari

Aleyasin

Fyruzi

et al. 2015

Arch Pediatr Infect Dis

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“…Additionally, the seasonality of the infection is similar to that of RSV, peaking in the winter months (20,30). Recent studies on lung transplant recipients, bone marrow recipients, and preterm infants have shown that hMPV can be isolated from patients with respiratory infections in this immunocompromised population, suggesting that some of the risk factors associated with RSV infection may be similarly associated with hMPV infection (8,10,14,18,25,29).…”

mentioning

confidence: 95%

Isolation and Characterization of Monoclonal Antibodies Which Neutralize Human Metapneumovirus In Vitro and In Vivo

Ulbrandt¹,

Ji²,

Patel³

et al. 2006

J Virol

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Human metapneumovirus (hMPV) is a recently described member of the Paramyxoviridae family/Pneumovirinae subfamily and shares many common features with respiratory syncytial virus (RSV), another member of the same subfamily. hMPV causes respiratory tract illnesses that, similar to human RSV, occur predominantly during the winter months and have symptoms that range from mild to severe cough, bronchiolitis, and pneumonia. Like RSV, the hMPV virus can be subdivided into two genetic subgroups, A and B. With RSV, a single monoclonal antibody directed at the fusion (F) protein can prevent severe lower respiratory tract RSV infection. Because of the high level of sequence conservation of the F protein across all the hMPV subgroups, this protein is likely to be the preferred antigenic target for the generation of cross-subgroup neutralizing antibodies. Here we describe the generation of a panel of neutralizing monoclonal antibodies that bind to the hMPV F protein. A subset of these antibodies has the ability to neutralize prototypic strains of both the A and B hMPV subgroups in vitro. Two of these antibodies exhibited high-affinity binding to the F protein and were shown to protect hamsters against infection with hMPV. The data suggest that a monoclonal antibody could be used prophylactically to prevent lower respiratory tract disease caused by hMPV.Respiratory viruses account for a large proportion of upper and lower respiratory tract illness in humans. In the past few decades, many etiological agents of respiratory tract illness have been identified. Of these, respiratory syncytial virus (RSV) is the single most important cause of respiratory infections during infancy and early childhood (29). However, only 60% of clinically attended respiratory infections of infants and children are of a known etiology (21). Recently, van den Hoogen et al. (26) discovered and described human metapneumovirus (hMPV) and revealed that it may account for a portion of these previously unclassified infections. Prospective and retrospective studies suggest that hMPV infections account for between 3% and 15% of respiratory tract infections (5,6,8

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“…The most frequent diagnoses in hospitalized children are bronchiolitis and pneumonia, but occasionally hMPV may also cause severe illnesses that require treatment at intensive care units (17,18).…”

mentioning

confidence: 99%

Human Metapneumovirus Infections in Children

Heikkinen

Österback

Peltola

et al. 2008

Emerg. Infect. Dis.

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Human metapneumovirus (hMPV) is an important cause of lower respiratory tract infections in hospitalized children, but the age-related incidence and effect of hMPV in unselected children in the community have not been evaluated. We studied a cohort of 1,338 children <13 years of age throughout 1 respiratory season in Finland during [2000][2001]. We examined children and obtained a nasal swab for viral detection at any sign of respiratory infection. hMPV was detected in 47 (3.5%) of the 1,338 children. The age-related incidence of hMPV infection was highest (7.6%) in children <2 years of age, in whom hMPV accounted for 1.7% of all infections during the season. During the epidemic peak, hMPV caused 7.1% of all respiratory infections in the cohort. Acute otitis media developed in 61% of hMPVinfected children <3 years of age. Our fi ndings demonstrate that the effect of hMPV in the community is greatest in children <2 years of age.

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Life-Threatening Human Metapneumovirus Pneumonia Requiring Extracorporeal Membrane Oxygenation in a Preterm Infant

Cited by 37 publications

References 14 publications

The Prevalence of Human Metapneumovirus and Respiratory Syncytial Virus and Coinfection With Both in Hospitalized Children With Acute Respiratory Infection in South of Iran

The Prevalence of Human Metapneumovirus and Respiratory Syncytial Virus and Coinfection With Both in Hospitalized Children With Acute Respiratory Infection in South of Iran

Isolation and Characterization of Monoclonal Antibodies Which Neutralize Human Metapneumovirus In Vitro and In Vivo

Human Metapneumovirus Infections in Children

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