Life-threatening gastrointestinal haemorrhage requiring surgical resection caused by SARS-CoV-2 induced ANCA associated vasculitis: A case report

Giles, Thomas; Roy, Susmit; Chandrasoma, Dani; Oakley, S. P.; Lynnhtun, Kyaw; Draganic, Brian

doi:10.1016/j.ijscr.2022.107491

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…By June 2023 (searching PubMed,CNKI and Wanfang Data ), a total of 9 English cases of GPA following COVID-19 infection involvement and no Chinese case were found by searching literature [4][5][6][7][8][9][10][11][12]. Combined with our case,there were 10 cases of GPA following COVID-19 infection.…”

Section: Results From the Literature Reviewmentioning

confidence: 53%

COVID-19- induced Granulomatosis with Polyangiitis：a Case Report and Literature Review

Jiang,

Zhou,

Wen

et al. 2024

Preprint

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Objective To report a case of Granulomatosis with Polyangiitis (GPA)with Diffuse alveolar hemorrhage(DAH)that developed following Coronavirus disease 2019 (COVID-19) in an adolescent boy, and perform a literature review to better understand this disorder.Methods Retrospectively analyze the data of a case of GPA following COVID-19 infection, to summarize the clinical characteristics of GPA following COVID-19 infection by searching the database (PubMed,Wanfang Data,CNKI) and comprehensively analyze the literature results. Results 9 cases were reported，combined with our case，there were 10 cases of GPA following COVID-19 infection,including 4 males and 6 females,with an average age of(40.6±18.6)years,and the time interval between COVID-19 and diagnosis of GPA ranged from 1 day to 3 months for all 10 cases. The rate of mortality was 10.0%(1/10).Commonly seen clinical manifestations were cough(70.0%),dyspnea(50.0%),and Arthralgia/Myalgia(40.0%). CT scans showed ground-glass opacities，multifocal pulmonary nodules.Of all these patients, c-ANCA and PR3-antibody positivity were found .Conclusion COVID-19 pneumonia and COVID-19- induced new-onset GPA share many clinical and radiological features, making it challenging for clinicians to distinguish between the two. Our study also provided some clues about the diagnostic challenge of GPA induced by COVID-19.

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Section: Results From the Literature Reviewmentioning

confidence: 53%

COVID-19- induced Granulomatosis with Polyangiitis：a Case Report and Literature Review

Jiang,

Zhou,

Wen

et al. 2024

Preprint

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“…AAV can mimic COVID-19 in terms of lung involvement, COVID-19 can co-occur with AAV, and COVID-19 can cause AAV-like symptoms [12]. The development of AAV after the transfer of COVID-19 is reported in many clinical reports [3,[11][12][13][24][25][26][27][28][29]. The diagnosis of new ANCA-associated vasculitis can be difficult in the context of severe infection with COVID-19 due to common anatomical areas of infection and inflammation [30].…”

Section: Presentation Of Clinical Cases Casementioning

confidence: 99%

“…Today, there is more and more evidence that SARS-CoV-2 is another virus that can lead to disruption of the regulation of the immune system and provoke the appearance or exacerbate already existing autoimmune diseases in children and adults [24][25][26][31][32][33][34][35], especially in genetically predisposed individuals [12,32,35]. Moreover, numerous new autoimmune diseases in adults have been described in the literature as post-infectious complication of COVID-19 infection [25].…”

Section: Presentation Of Clinical Cases Casementioning

confidence: 99%

Microscopic polyangiitis hiding behind the mask of COVID-19: A case series and minireview

Yarmola¹,

Gutsalenko²,

Katerenchuk³

et al. 2023

Ukr. J. Nephrol. and Dial.

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Microscopic polyangiitis (MPA) is one of the three clinical phenotypes of vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA). Although MPA is considered a rare form of ANCA-associated vasculitis (AAV), clinical evidence shows that it is fairly common among nephrologists, as it manifests as a systemic, weak-immune vasculitis affecting glomerular capillaries, resulting in necrotizing glomerulonephritis (GN) diagnosed in nearly 100% of MPA patients. The issue of AAV in general, and MPA specifically, has gained significant importance in the context of the ongoing SARS-CoV-2 coronavirus pandemic, as both conditions share common anatomical sites of infection and inflammation. This study presents three new cases of MPA in post-COVID-19 patients. The analysis and presentation encompassed demographic data, patient history regarding comorbidities, details of follow-up care, chronology with COVID-19, and laboratory findings at the time of MPA diagnosis. A comparative analysis of the chronological progression of MPA in the documented clinical cases reveals the polymorphic nature of early-stage clinical manifestations, as well as diverse patterns of disease progression in the advanced stage. Additionally, we provide a brief literature review on diagnostic challenges, pathogenetic mechanisms underlying the relationship between SARS-CoV-2 and AAV, and peculiarities of clinical presentations in early and advanced stages of MPA.

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New‐onset ANCA‐associated vasculitis presenting with neuropathy after COVID‐19 infection: A case report and literature review

Mohamadi,

Soroureddin,

Nayebirad

et al. 2024

Clinical Case Reports

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Key Clinical MessageCoronavirus Disease 2019 (COVID‐19) is a viral infection caused by SARS‐CoV‐2, which can trigger autoimmune diseases such as antineutrophilic cytoplasmic antibody (ANCA) associated vasculitis (AAV) that affect small and medium‐sized blood vessels in multiple organs. This study discusses a case with neuropathy and positive ANCA after COVID‐19 infection and reviews the literature on AAV following COVID‐19 infection. A 59‐year‐old man is presented that was referred to Shariati Hospital for evaluation of neurologic problems after a COVID‐19 infection. Initially, he had flu‐like symptoms. A few days later, he developed right distal upper and lower limb paresthesia. His electromyography (EMG) and nerve conduction velocity (NCV) results were consistent with polyneuropathy. Lumbar puncture (LP) was normal except for positive COVID‐19 polymerase chain reaction (PCR). The patient's paresthesia worsened. Laboratory data showed leukocytosis, anemia, thrombocytosis, high erythrocyte sedimentation rate (ESR), and C‐reactive protein (CRP). Perinuclear anti‐neutrophil cytoplasmic antibody (MPO‐ANCA) was positive. According to the results, vasculitis was the main differential diagnosis. The sural nerve biopsy was performed, and the result was consistent with small to medium‐sized vessel vasculitis. The patient was diagnosed with COVID‐induced AAV. He was prescribed methylprednisolone and cyclophosphamide and was discharged with prednisolone and cotrimoxazole. In this study, a unique case of AAV induced by COVID‐19 infection confirmed by nerve biopsy is presented. A review of the literature found 48 cases of new‐onset AAV in adults and pediatrics after COVID‐19 infection. Further research is needed to completely understand the relationship between COVID‐19.

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Life-threatening gastrointestinal haemorrhage requiring surgical resection caused by SARS-CoV-2 induced ANCA associated vasculitis: A case report

Cited by 5 publications

References 18 publications

COVID-19- induced Granulomatosis with Polyangiitis：a Case Report and Literature Review

COVID-19- induced Granulomatosis with Polyangiitis：a Case Report and Literature Review

Microscopic polyangiitis hiding behind the mask of COVID-19: A case series and minireview

New‐onset ANCA‐associated vasculitis presenting with neuropathy after COVID‐19 infection: A case report and literature review

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