Life-threatening Dilated Cardiomyopathy Induced by Late-onset Neonatal Hypocalcemia

Chou, Po-Ching; Lin, Lung‐Chang; Hsu, Jong Hau; Yang, Rei‐Cheng; Jong, Yuh‐Jyh; Dai, Zen Kong; Wu, Jiunn‐Ren

doi:10.1016/j.pedneo.2014.05.007

Cited by 5 publications

(7 citation statements)

References 13 publications

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“…Rickets, although becoming a serious and a big epidemiological problem especially in sunny countries, should not be considered as a mere benign disease of bones, as it has serious life-threatening associations more likely to be missed. Even in neonates, as seen in this 14-day-old infant recently reported on [17], which was the youngest ever case presenting with hypocalcemic seizures and dilated cardiomyopathy. He developed life-threatening respiratory distress and heart failure.…”

Section: Discussionmentioning

confidence: 78%

Rachitic hypocalcemic cardiomyopathy in an infant

Elidrissy

Al-Harbi

Mufid

et al. 2017

Journal of the Saudi Heart Association

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Cardiomyopathy in infants is characterized by heart failure in apparently normal children without previous organic cardiac lesions. Cardiomyopathy has been found to comprise four types. Rickets is common in Saudi Arabia, that is why I reviewed this subject. Recently this case with classical features of rickets being admitted in a serious state we thought of publishing it. The infant responded well to treatment and full recovery was achieved. Follow up biochemistry, radiology cardiac function completely recovered and bony abnormalities showed evidence of healing. This case might have been missed as respiratory infection. We recommend meticulous look for biochemical features of rickets in infants admitted with respiratory symptoms.

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Section: Discussionmentioning

confidence: 78%

Rachitic hypocalcemic cardiomyopathy in an infant

Elidrissy

Al-Harbi

Mufid

et al. 2017

Journal of the Saudi Heart Association

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“…Infants and children with vitamin D deficiency can develop dilated cardiomyopathy, which is usually reversible and is attributed to prolonged hypocalcaemia. 10,18,20,21 However, the exact mechanism of dilated cardiomyopathy has not been fully elucidated. In our cohort, echocardiographic parameters (ejection fraction, shortening fraction, left ventricle end-diastolic diameter, left ventricle end-systolic diameter) did not show evidence of dilated cardiomyopathy or ventricular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…We compared the biochemical and echocardiographic parameters of the present cohort with those of previously published 27 patients with confirmed dilated cardiomyopathy due to vitamin D-deficient rickets (historical group). [12][13][14][18][19][20][21][22][23][24][25][26][27][28][29]…”

Section: Methodsmentioning

confidence: 99%

Clinical, biochemical, and echocardiographic evaluation of neonates with vitamin D deficiency due to maternal vitamin D deficiency

et al. 2021

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Objective: There are a few number of case reports and small-scale case series reporting dilated cardiomyopathy due to vitamin D-deficient rickets. The present study evaluates the clinical, biochemical, and echocardiographic features of neonates with vitamin D deficiency. Patients and methods: In this prospective single-arm observational study, echocardiographic evaluation was performed on all patients before vitamin D3 and calcium replacement. Following remission of biochemical features of vitamin D deficiency, control echocardiography was performed. Biochemical and echocardiographic characteristics of the present cohort were compared with those of 27 previously published cases with dilated cardiomyopathy due to vitamin D deficiency. Results: The study included 148 cases (95 males). In the echocardiographic evaluation, none of the patients had dilated cardiomyopathy. All of the mothers were also vitamin D deficient and treated accordingly. Comparison of patients with normocalcaemia and hypocalcaemia at presentation revealed no statistically significant difference between the ejection fraction and shortening fraction, while left ventricle end-diastolic diameter and left ventricle end-systolic diameter were higher in patients with hypocalcaemia. Previously published historical cases were older and had more severe biochemical features of vitamin D deficiency. Conclusion: To the best of our knowledge, in this first and largest cohort of neonates with vitamin D deficiency, we did not detect dilated cardiomyopathy. Early recognition and detection before developing actual rickets and preventing prolonged hypocalcaemia are critically important to alleviate cardiac complications.

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“…Late diagnosis causes complications such as cardiopulmonary dysfunction, hypocalcemic seizure and tetany, which increase neonatal morbidity and mortality (8,9). The aim of the present study was to determine the frequency of early and late hypocalcemia in hospitalized neonates and assess its associated factors.…”

Section: Discussionmentioning

confidence: 99%

The Frequency of Early and Late Hypocalcemia Among Hospitalized Newborns in An Iranian Hospital

et al. 2015

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Background: Hypocalcemia is a common neonatal abnormality particularly in high-risk neonates. Hypocalcaemic neonates with early diagnosis recover after a period of treatment with calcium. Objectives: In this study we aimed to determine the frequency of early and late hypocalcemia, as well as the influence of some relating factors. Patients and Methods: One hundred neonates with early or late hypocalcemia (hospitalized in Aliasghar Hospital of Tehran, Iran, during 2011) were enrolled. The required information was extracted from medical records. The frequency of each hypocalcemia type and relating factors were assessed. Results: Amongst all subjects, 63% had early and 37% had late hypocalcemia. We found significant associations between early or late hypocalcemia with Apgar score of < 5 and prematurity (P < 0.05). Conclusions: Calcium supplemented food could prevent hypocalcemia complications in high-risk neonates.

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Life-threatening Dilated Cardiomyopathy Induced by Late-onset Neonatal Hypocalcemia

Cited by 5 publications

References 13 publications

Rachitic hypocalcemic cardiomyopathy in an infant

Rachitic hypocalcemic cardiomyopathy in an infant

Clinical, biochemical, and echocardiographic evaluation of neonates with vitamin D deficiency due to maternal vitamin D deficiency

The Frequency of Early and Late Hypocalcemia Among Hospitalized Newborns in An Iranian Hospital

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