Life‑threatening complications of hyperemesis gravidarum

Popa, Stefan L.; Barsan, Maria; Caziuc, Alexandra; Preda, Cristina; Mureşan, Lucian; Popa, Luminita Celia; Perju‐Dumbravă, Lăcrămioara

doi:10.3892/etm.2021.10074

Cited by 12 publications

(13 citation statements)

References 58 publications

(130 reference statements)

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“…Nach einer Bevölkerung -basierten Kohortenstudie aus England wiesen Schwangere mit HG und Notwendigkeit zur Hospitalisierung ein 1,2- bis 2-faches Risiko für Anämie, Präeklampsie und für venöse Thromboembolien auf 63 . In einer systematischen Übersicht wurden die seltenen, lebensbedrohlichen Komplikationen einer HG (u. a. Wernicke-Enzephalopathie, Elektrolytentgleisungen, Schlaganfall, zentrale Venenthrombose) zusammengefasst 64 . Eine weitere detaillierte systematische Übersicht über die mütterlichen und fetalen Komplikationen bei HG findet sich bei Gabra 2018 8 .…”

Section: Mütterliche Und Kindliche Komplikationenunclassified

Hyperemesis gravidarum – eine interprofessionelle und interdisziplinäre Herausforderung

Rath,

Maul,

Abele

et al. 2023

Z Geburtshilfe Neonatol

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ZusammenfassungDie Hyperemesis gravidarum (HG) ist eine multifaktorielle Erkrankung, charakterisiert durch persistierende Übelkeit/Erbrechen, Dehydratation, Gewichtsverlust von mindestens 5%, Elektrolytstörungen und Ketoazidose. Die Prävalenz liegt weltweit zwischen 0,3 und 10%. Die Diagnose wird anhand der Anamnese, der klinischen Symptome, der körperlichen Untersuchung und der typischen Laborveränderungen gestellt. Grundpfeiler der Therapie sind Ernährungsberatung, Beratung zum Lebensstil, psychologische/psychosoziale Unterstützung der Schwangeren und die Gabe von Antiemetika im Sinne eines sich an dem Schweregrad der Symptome orientierenden Stufenkonzepts. Ein häufiger Wechsel von Antiemetika ist zu vermeiden. Die Behandlung der HG erfordert eine enge interprofessionelle und interdisziplinäre Zusammenarbeit.

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Section: Mütterliche Und Kindliche Komplikationenunclassified

Hyperemesis gravidarum – eine interprofessionelle und interdisziplinäre Herausforderung

Rath,

Maul,

Abele

et al. 2023

Z Geburtshilfe Neonatol

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“…Five patients, # 9,18,20,27,29, (13%) presented with severe hypokalemia, which can be associated with serious cardiac arrhythmias and sudden death [85][86][87].…”

Section: Mehreen 2022mentioning

confidence: 99%

Gestational Malnutrition is Still the Skeleton in the Closet: Where Are the Malnutrition Risk Screening Criteria?

Erick

2023

Womens Health Care Issues

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In 2020 there were 3,613,647 live births in the US. Fifty to 90% of those pregnancies were affected by nausea and vomiting of pregnancy (NVP) while the most severe NVP, known as hyperemesis gravidarum (HG) affected 1.5- 3.0% of those gravidas. In 2014 58,436 gravidas were hospitalized with HG. While hospital admissions for HG were down 42%, the number seen in Emergency departments rose by 27.7%. Although HG has been viewed as a positive predictor of a favorable pregnancy outcome, patients who also demonstrate weight loss and electrolyte disturbance may be a distinct entity and at greater risk for growth retardation and fetal anomalies. Poorly managed HG can result in compounded maternal injuries, increased rates of therapeutic abortions and suicide ideation, as well as a high rate of fetal loss. This study focuses on one of the most severe catastrophes originating from HG: Wernicke’s encephalopathy (WE) continues to be an under-recognized and often misunderstood disease in all populations. The acknowledged cause of WE is vitamin B1 or thiamin deficiency, a specific form of malnutrition. Unfortunately, this syndrome is most often recognized at autopsy, especially among non-alcoholics. One manifestation of WE is cognitive dysfunction which may explain the increase in suicidal ideation and/or elected terminations. The current mounting legislation of pregnancy termination limits will complicate the decision to abort for critically ill gravidas and their medical providers. However, antecedent events to WE are extremely poor nutritional intake leading to excessive weight loss and delayed nutritional interventions which can mitigate these situations.

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“…Patients with HG are at risk for developing Wernicke encephalopathy (e.g., ataxia, nystagmus, confusion) (11). Other complications associated with HG include, but are not limited to, hematemesis from an esophageal tear (Mallory-Weiss tear), esophageal rupture (Boerhaave syndrome), liver injury, pneumothorax, placental detachment or hemorrhage, splenic avulsion, and preretinal hemorrhage (12).…”

Section: Symptomsmentioning

confidence: 99%