Life-threatening complications of ascariasis in trauma patients: a review of the literature

Quan-yue, LI; Zhao, Donghai; Qu, Haiyan; Zhou, Changxi

doi:10.5847/wjem.j.issn.1920-8642.2014.03.001

Cited by 13 publications

(7 citation statements)

References 20 publications

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“…While our patient had a simple gastrointestinal infection, several pulmonary complications of ascariasis have been reported (2). Adult worms can cause largyngospasm as well as mechanical obstruction of the airway which can result in cardiac arrest (3,4).…”

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confidence: 72%

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Medical image of the week: ascaris lumbridoies

Wong¹,

Fernandes²,

Huang³

et al. 2015

Southwest J Pulm Crit Care

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confidence: 72%

“…Candy Wong 1 ; Aaron Fernandes 2 , Jennifer Huang 2 , and Sachin Chaudhary 1 1 Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine. 2 Department of Medicine University of Arizona Tucson, AZ…”

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confidence: 99%

Medical image of the week: ascaris lumbridoies

Wong¹,

Fernandes²,

Huang³

et al. 2015

Southwest J Pulm Crit Care

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“…Las complicaciones graves de la parasitosis intestinal por helmintos representan un rotundo fracaso de los programas de atención primaria y (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) prevención en salud pública . El costo del tratamiento de dichas complicaciones, no solo, es varias veces superior al tratamiento preventivo sino que; además deja secuelas difíciles de superar a corto y mediano plazo por la poca o nula intervención de los múltiples factores predisponentes antes ya m e n c i o n a d o s .…”

Section: A B Discusiónunclassified

Ascaris Lumbricoides: complicaciones cardíacas y resolución quirúrgica de urgencia

Garay¹,

Caballero²,

Álvarez³

et al. 2019

Pediatr (Asunción).

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Introducción: La parasitosis intestinal por Geohelmintiasis es una de las Enfermedades Infecciosas Desatendidas (OMS), que afecta a poblaciones vulnerables. Existen factores predisponentes como: condiciones precarias de vivienda, bajos ingresos económicos y nivel educativo deficiente. De los helmintos, el Ascaris lumbricoides es el más grande nematodo intestinal en humanos -alcanza hasta 40 centímetros-. La presentación clínica depende del grado de infestación variando desde anemia, astenia, pérdida de peso, hasta invasión interna de órganos blancos como hígado, pulmones, cerebro y corazón en casos extremos. Caso Clínico: Niña de 16 meses de edad, con historia de fiebre prolongada y expulsión espontánea de parásitos por orificio naturales, que llega al servicio de urgencias con síntomas de shock cardiorrespiratorio. Se realiza Ecocardiográfía visualizándose imágenes de cuerpos extraños en forma de cintas y con movimientos espontáneos, compatibles con parásitos de localización cardíaca (2 en aurícula y ventrículo derecho y 1 cabalgando las arterias pulmonares); en el seguimiento ecocardiográfico se constatan múltiples trombos a lo largo del parásito localizado en aurícula derecha y, que dada la gravedad del cuadro se determinó su extracción quirúrgica de urgencia. Se extrajeron 4 parásitos adultos,y, coágulos adherido a uno de ellos. Discusión: El estudio parasitológico y anatomopatológico concluyó que correspondían a hembras adultas de Ascaris lumbricoides. Alta al 8° día post-operatorio en buenas condiciones. Aunque este caso fue exitoso, las complicaciones cardiacas e infecciones sistémicas graves, son de alta morbi-mortalidad, que pueden evitarse con programas de desparasitación y reducción de carga parasitaria mediante mejoras en el saneamiento ambiental y educación sanitaria. A nuestro conocimiento este es el primer caso reportado en el mundo, de extracción de Ascaris Lumbricoides formas adultas del Corazón humano. Correspondencia: Garay Nancy Correo: nancygareche@hotmail.com Conflicto de interés: Los autores declaran no poseer conflicto de interés Recibido: 28/12/2018 Aceptado: 20/06/2019

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“…During larval migration from the lungs to the alveoli, several haemorrhagic foci may occur in the organ leading to pulmonary infections such as hypersensitivity pneumonitis, referred to as Loeffler syndrome (Bharti et al , 2018). The presence of a large number of parasites in the intestine may have a ‘scavenging’ action in which adults consume large amounts of the host's nutrients, leading to malnutrition (Li et al , 2014). The risk of intestinal obstruction is ten times higher in individuals with high worm burden, in which case urgent surgical treatment is required (Andrade et al , 2015; Parija et al , 2017).…”

Section: Introductionmentioning

confidence: 99%

Anti-Ascaris suumimmunoglobulin Y as a novel biotechnological tool for the diagnosis of human ascariasis

et al. 2019

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Human ascariasis is a neglected tropical disease of great relevance to public health and is considered the most frequent helminthiasis in poor regions. Accurately diagnosing this parasite has been challenging due to limitations of current diagnostic methods. Immunoglobulin Y (IgY) technology is a very effective alternative for the production of highly specific and profitable antibodies. This study aimed to produce and apply anti-Ascaris suum IgY antibodies in the immunodiagnosis of human ascariasis. Five immunizations comprising total saline extract from A. suum adult life forms were given at 14-day intervals to Gallus gallus domesticus hens of the Isa Brown line. Eggs and blood samples were collected weekly and fortnightly, respectively, to monitor the production of antibodies. The specificity of antibodies was confirmed by dot-blot, kinetic enzyme-linked immunosorbent assay (ELISA), avidity ELISA, immunoblotting and indirect immunofluorescence antibody tests. The application for disease diagnosis was performed through the detection of immune complexes in human serum samples by sandwich ELISA. Peaks of IgY anti-A. suum production occurred at weeks 6 and 8. IgY showed high avidity levels after the second dose of immunization, ranging from 64% to 93%, with a mean avidity index of 78.30%. Purified IgY recognized 12 bands of proteins from A. suum saline extract. Eggs, the uterine portion and cuticles of A. suum female adult are reactive in immunofluorescence. The detection of immune complexes showed diagnostic values of 80% sensitivity and 90% specificity. In conclusion, specific IgY have been shown to be a potential immunodiagnostic tool with promising future applications in human ascariasis.

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Life-threatening complications of ascariasis in trauma patients: a review of the literature

Cited by 13 publications

References 20 publications

Medical image of the week: ascaris lumbridoies

Medical image of the week: ascaris lumbridoies

Ascaris Lumbricoides: complicaciones cardíacas y resolución quirúrgica de urgencia

Anti-Ascaris suumimmunoglobulin Y as a novel biotechnological tool for the diagnosis of human ascariasis

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