Life-Threatening Cat-Scratch Disease in an Immunocompromised Host

Black, Jonathan

doi:10.1001/archinte.1986.00360140238035

Cited by 37 publications

(13 citation statements)

References 8 publications

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“…A comprehensive literature search identified 37 reported cases of solid organ transplant recipients who developed Bartonella infections with clinical pictures ranging from typical granulomatous suppurative lymphoid involvement to unusual presentations such as chorioretinitis . In the analysis of 29 cases by Psarros et al.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, an increasing number of putatively immune para‐infectious or post‐infectious disorders have been reported in association with Bartonella infections affecting the central nervous system and other organs (see Table ; ). Specifically, a case of post‐infectious chronic active myocarditis has been reported , as well as renal involvement in the form of immune‐complex mediated or pauci‐immune acute glomerulonephritis .…”

Section: Reported Clinicopathological Associations With Cat Scratch Dmentioning

confidence: 99%

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Bartonella henselae infection‐associated vasculitis and crescentic glomerulonephritis leading to renal allograft loss

Chaudhry

Papadimitriou

et al. 2015

Transplant Infectious Dis

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Bartonella henselae (BH) is the main cause of cat scratch disease (CSD), which more typically presents as a self-limited localized suppurative lymphadenopathy in immunocompetent individuals. In contrast, immunocompromised patients commonly have systemic disease with life-threatening complications. In addition to the angioproliferative lesions, such as bacillary angiomatosis, an increasing number of immune post-infectious complications are being recognized with BH infections, including glomerulonephritis, vasculitis, hemophagocytic syndrome, and neurological problems. We report the case of a renal transplant recipient who developed CSD in the second year post transplantation. In addition to prolonged fever and generalized lymphadenopathy and splenomegaly requiring differentiation from a post-transplant lymphoproliferative disorder, the course was complicated by the development of dermal leukocytoclastic vasculitis and pauci-immune necrotizing and crescentic glomerulonephritis, which led to failure of the renal graft. Glomerulonephritis as a complication of CSD has never been described in a kidney allograft, to our knowledge. Awareness of the diverse clinical symptoms associated with BH, including granulomatous/suppurative lesions and other less common complications can lead to more rapid and accurate diagnosis. Also, as recommended by the current guidelines, a thorough history of pet ownership should be part of the clinical evaluation before and after transplantation for all transplant recipients.

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Section: Discussionmentioning

confidence: 99%

Section: Reported Clinicopathological Associations With Cat Scratch Dmentioning

confidence: 99%

Bartonella henselae infection‐associated vasculitis and crescentic glomerulonephritis leading to renal allograft loss

Chaudhry

Papadimitriou

et al. 2015

Transplant Infectious Dis

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“…Four kidney transplant recipients with unusual or systemic presentations of B. henselae infection have also been described. Fever, lymphadenopathy, and septic shock occurred in a 34‐yr‐old male 14 yr following kidney transplantation (13). A 24‐yr‐old male presented with fever, a soft tissue chest mass, and bacillary angiomatosis (14).…”

Section: Discussionmentioning

confidence: 99%

Cat‐scratch disease relapse in a kidney transplant recipient

Rheault¹,

Burik²,

Mauer³

et al. 2006

Pediatric Transplantation

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Cat-scratch disease, an infectious illness infrequently reported in kidney transplant patients, is caused by the organism Bartonella henselae and is transmitted through contact with cats or kittens. It is a self-limited disorder in the general pediatric population. Here we present a case of unsuspected cat-scratch disease in a pediatric kidney transplant patient who presented with fever and lymphadenopathy. Eight months after treatment with a short course of azithromycin, the patient developed a recurrence of cat-scratch disease. We emphasize that the evaluation of a young immunocompromised kidney transplant patient presenting with fever and lymphadenopathy should include unusual infections such as cat-scratch disease. We review the diagnosis and treatment of this uncommon infection in the organ transplant population.

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“…Additional reports followed, detailing infections predominantly in HIV positive patients, and the clinical spectrum of bacillary angiomatosis grew to include lesions in lymph nodes, brain, bone, liver (peliosis hepatis), and spleen (18,45,49,65,82). The presence of WarthinStarry-staining bacilli in these lesions led several authors to speculate as to the possible role of the cat-scratch disease bacillus in disseminated disease recognized as bacillary angiomatosis (6,45,47,51). Furthermore, several reports of bacillary angiomatosis cases noted a history of patients having cat contact prior to disease onset (45,80,82).…”

Section: Search For the Agentmentioning

confidence: 99%

“…Regnery and colleagues, recalling the previously noted ambivalence regarding the distinctions between some examples of bacillary angiomatosis and catscratch disease (6,45,47,51), the absence of cat-scratch disease-associated A. felis isolates from more than one research institute, and the absence of convincing serologic evidence linking A. felis and cat-scratch disease, applied the new R. henselae serologic test to a collection of sera collected from patients with suspect, but unconfirmed, cat-scratch disease (69). Of 41 single serum samples, 36 (88%) demonstrated significant titers to R. henselae; high-titered antibodies were not detected when A. felis antigen was used with the same sera.…”

Section: Search For the Agentmentioning

confidence: 99%

Will the Real Agent of Cat-Scratch Disease Please Stand Up?

Jerris

Regnery

1996

Annu. Rev. Microbiol.

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Cat-scratch disease has been recognized since 1889 in association with the oculoglandular syndrome of Parinaud. The epidemiologic association with cats was first made in 1931 and further substantiated throughout the years, refining the interaction predominantly to kittens. Putative infectious agents have included numerous species of bacteria, chlamydiae, and viruses. The cultivation of Afipia spp. in the late 1980s appeared to answer the mystery of the identity of the agent. However, even more recent analysis, which has combined traditional microbiology, molecular methods, and additional epidemiology, has demonstrated that Bartonella (Rochalimaea) henselae is the definitive agent of cat-scratch disease. Our understanding of the pathogenesis of cat-scratch disease and other diseases caused by Bartonella species is incomplete and the spectrum of diseases continues to emerge. We review historic and modern efforts to understand the etiology of cat-scratch disease and related syndromes.

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Life-Threatening Cat-Scratch Disease in an Immunocompromised Host

Cited by 37 publications

References 8 publications

Bartonella henselae infection‐associated vasculitis and crescentic glomerulonephritis leading to renal allograft loss

Bartonella henselae infection‐associated vasculitis and crescentic glomerulonephritis leading to renal allograft loss

Cat‐scratch disease relapse in a kidney transplant recipient

Will the Real Agent of Cat-Scratch Disease Please Stand Up?

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