Life-Style and Occupational Risk Factors in Cancer of the Lower Urinary Tract

Claude, J.; Kunze, Ekkehard; Frentzel‐Beyme, Rainer; Paczkowski, Kurt; Schneider, Johannes; Schubert, Heinrich

doi:10.1093/oxfordjournals.aje.a114430

Cited by 168 publications

(116 citation statements)

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“…High consumption of fluids may reduce this exposure. One prospective study demonstrated this negative association (28), whereas other studies reported positive associations (13,(29)(30)(31)(32)(33) or no association (15,34). Correction for total water intake did not change the results substantially.…”

Section: Discussionmentioning

confidence: 98%

Alcohol Consumption and Bladder Cancer Risk: Results from the Netherlands Cohort Study

Volovics¹,

Dorant²,

Goldbohm³

et al. 2001

American Journal of Epidemiology

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Although several epidemiologic studies have been conducted on alcohol consumption and bladder cancer risk, the risk according to quantity and type of alcohol consumed is not clear. The authors investigated these associations in a large prospective cohort study on diet and cancer among 120,852 subjects in the Netherlands aged 55-69 years at baseline (1986). Subjects completed a questionnaire on risk factors for cancer, including alcohol consumption. Follow-up for incident cancer was established by record linkage to cancer registries. The case-cohort analysis was restricted to a follow-up period of 6.3 years and was based on 594 cases with bladder cancer and 3,170 subcohort members. The authors corrected for age and smoking in multivariable analyses. The incidence rate ratios for men who consumed <5, 5-<15, 15-<30, and ≥30 grams of alcohol per day were 1.49, 1.52, 1.16, and 1.63 compared with nondrinkers, respectively (p for trend = 0.13). Alcohol consumed from beer, wine, and liquor was associated with moderately elevated risks, although most were not statistically significant. The incidence rate ratios for women varied around unity. The results of this study do not suggest an important association between alcohol consumption and bladder cancer risk. Although several epidemiologic studies have been conducted to investigate the association between alcohol consumption and bladder cancer risk, the risk according to quantity and type of alcohol consumed is still not clear. In a recent meta-analysis of these studies, a slightly elevated risk of bladder cancer was demonstrated for men currently drinking alcohol compared with abstainers (1). In this metaanalysis, however, no data were available to explore the influence of quantity and types of alcoholic beverages consumed. These results prompted us to investigate these associations in more detail in the ongoing Netherlands Cohort Study. MATERIALS AND METHODS CohortThe study design has been described in detail previously (2). The study population originated from 204 municipal population registries throughout the Netherlands, and the cohort includes 58,279 men and 62,573 women who were aged 55-69 years at baseline (1986). We used the case-cohort approach for data processing and analysis (3). A subcohort of 3,500 subjects was randomly sampled from the cohort after baseline exposure measurement and was followed up to obtain vital status information. No subcohort members were lost to follow-up during the follow-up period. Follow-upFollow-up for incident cancer was established by record linkage to cancer registries and the Dutch database of pathology reports (4), and follow-up was more than 95 percent complete (5). The present analysis was restricted to 6.3 years of follow-up. After we excluded prevalent cases, 3,346 subcohort members and 619 incident cases with microscopically confirmed carcinomas of the bladder, ureters, renal pelvis, or urethra were identified. Because the overwhelming majority of tumors occurred in the bladder, and because the renal pelvis and ureter are ...

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Section: Discussionmentioning

confidence: 98%

Alcohol Consumption and Bladder Cancer Risk: Results from the Netherlands Cohort Study

Volovics¹,

Dorant²,

Goldbohm³

et al. 2001

American Journal of Epidemiology

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“…A number of case -control studies have examined the possible association of UTIs with bladder cancer in developed countries (Howe et al, 1980;Kantor et al, 1984;Claude et al, 1986;Piper et al, 1986;Kjaer et al, 1989;Gonzalez et al, 1991;La Vecchia et al, 1991;Sturgeon et al, 1994;Jhamb et al, 2007). The overall evidence supports an increased risk from UTIs.…”

Section: Discussionmentioning

confidence: 99%

“…An experimental study in rats has shown associations between chronic infections with Escherichia coli and early bladder neoplasia (Davis et al, 1991), and it has been suggested that the high rates of bladder cancer in some parts of Africa and the Middle East may be due to the high prevalence of chronic infection with Schistosoma haematobium (IARC, 1994). A review of published epidemiological studies regarding the association between bladder infections and transitional cell carcinoma (TCC), the predominant type in developed countries, shows inconsistent results (Howe et al, 1980;Kantor et al, 1984;Claude et al, 1986;Piper et al, 1986;Kjaer et al, 1989;Gonzalez et al, 1991;La Vecchia et al, 1991;Sturgeon et al, 1994;Jhamb et al, 2007) and reveals a need for future studies to determine whether UTIs increase the risk of bladder cancer.…”

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confidence: 99%

Urinary tract infections and reduced risk of bladder cancer in Los Angeles

et al. 2009

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We investigated the association between urinary tract infections (UTIs) and transitional cell carcinoma of the bladder in a populationbased case -control study in Los Angeles covering 1586 cases and age-, gender-, and race-matched neighbourhood controls. A history of bladder infection was associated with a reduced risk of bladder cancer among women (odds ratio (OR), 0.66; 95% confidence interval (CI), 0.46 -0.96). No effect was found in men, perhaps due to power limitations. A greater reduction in bladder cancer risk was observed among women with multiple infections (OR, 0.37; 95% CI, 0.18 -0.78). Exclusion of subjects with a history of diabetes, kidney or bladder stones did not change the inverse association. A history of kidney infections was not associated with bladder cancer risk, but there was a weak association between a history of other UTIs and slightly increased risk among men. Our results suggest that a history of bladder infection is associated with a reduced risk of bladder cancer among women. Cytotoxicity from antibiotics commonly used to treat bladder infections is proposed as one possible explanation.

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“…Alguns tipos específicos de cân-cer, para os quais foi observado um excesso de óbi-tos entre os eletricitários, como cavidade oral/faringe, laringe e bexiga, têm o fumo como importante fator de risco 11 . Os resultados para câncer de cérebro, contudo, não poderiam ser explicados facilmente pela presença desse tipo de fator de risco.…”

Section: Discussionunclassified

“…Os óbitos por doença de Hodgkin, embora em pequeno número, se concentraram também na categoria de maior exposição (Tabela 5). Por outro lado, como já foi mencionado, diversos trabalhos têm mostrado uma associação entre fumo ou álcool e câncer de bexiga 10,11,49 , e esses antecedentes não são conhecidos para o grupo de eletricitários, o que não permite afastá-los como possíveis fatores de distorção dos resultados.…”

Section: Discussionunclassified

Mortalidade por câncer em trabalhadores de companhia geradora de eletricidade do Estado de São Paulo, Brasil

Mattos

Koifman

1996

Rev. Saúde Pública

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ResumoRealizou-se a análise exploratória de um conjunto de atestados de óbito de eletricitários do Estado de São Paulo (Brasil), através da Razão de Mortalidade Proporcional (PMR) e da Razão de Mortalidade Proporcional por Câncer (PCMR). Foi observado um discreto excesso de mortalidade por todas as localizações de câncer (PMR 1,11; IC 95% 0,91-1,35), estatisticamente não significativo. Encontrou-se elevação da PCMR, estatisticamente significativa, para câncer de laringe (PCMR 2,04; IC 95% 1,05-4,20). Um excesso de óbitos, embora sem significação estatística, foi observado para cavidade oral/faringe, próstata, bexiga, cérebro e doença de Hodgkin. A análise por categorias de exposição estimada a campos magnéticos mostrou PCMRs persistentemente elevadas para cancêr de bexiga (PCMR 4,17; IC 95% 1,35-9,72), cérebro (PCMR 3,77; IC 95% 1,02-9,65) e doença de Hodgkin (PCMR 5,55; IC 95% 1,14-16,21), no grupo com exposição provavelmente alta. Uma comparação com a mortalidade por câncer, de um grupo de trabalhadores petroquímicos, mostrou mortalidade elevada por neoplasma de laringe (PCMR 3,51; IC 95% 1,75-6,28) e bexiga (PCMR 7,53; IC 95% 3,02-15,51). Para tumores de cérebro, observou-se PCMR de 0,74 (IC 95% 0,61

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Life-Style and Occupational Risk Factors in Cancer of the Lower Urinary Tract

Cited by 168 publications

References 0 publications

Alcohol Consumption and Bladder Cancer Risk: Results from the Netherlands Cohort Study

Alcohol Consumption and Bladder Cancer Risk: Results from the Netherlands Cohort Study

Urinary tract infections and reduced risk of bladder cancer in Los Angeles

Mortalidade por câncer em trabalhadores de companhia geradora de eletricidade do Estado de São Paulo, Brasil

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