Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization

Frontera, Jennifer A.; Sabadia, Sakinah; Yang, Dixon; Havenon, Adam de; Yaghi, Shadi; Lewis, Ariane; Lord, Aaron; Melmed, Kara; Thawani, Sujata; Balcer, Laura J.; Wısnıewskı, Thomas; Galetta, Steven; Agarwal, Shashank; Andino, Andrés; Arena, Vito; Baskharoun, Samuel; Bauman, Kristie; Bell, Lena; Berger, Stephen; Bhagat, Dhristie; Bokhari, Matthew; Bondi, Steven A.; Canizares, Melanie; Chervinsky, Alexander; Czeisler, Barry; Dygert, Levi; Fang, Taolin; Flusty, Brent; Friedman, Daniel; Friedman, David; Fuchs, Benjamin; Granger, Andre; Gratch, Daniel; Gurin, Lindsey J.; Gutman, Josef; Hasanaj, Lisena; Holmes, Manisha; Horng, Jennifer; Huang, Joshua Zhexue; Ishii, Haruki; Jauregui, Ruben; Ji, Yuan; Kahn, D. Ethan; Koch, Ethan; Krieger, Penina; Kvernland, Alexandra; Lalchan, Rebecca; Lillemoe, Kaitlyn; Lin, Jessica; Liu, Susan B.; Madhavan, Maya; Medicherla, Chaitanya; Vernetti, Patricio Millar; Morgan, Nathaniel R.; Olivera, Anlys; Omari, Mirza; Park, George; Patel, Palak; Ristic, Milan; Rosenthal, Jonathan; Sonson, Michael; Snyder, Thomas M.; Stainman, Rebecca; Sunwoo, Brian; Talmasov, Daniel; Tamimi, Michael; Thomas, Betsy; Valdes, Eduard; Zhou, Ting; Zhu, Yingrong

doi:10.1016/j.jns.2022.120487

Cited by 20 publications

(9 citation statements)

References 65 publications

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“…Most studies of PCC have focused on infection-specific factors (what may be considered as direct factors), such as immunological aberrations, and other possible mechanisms—organ damage, endotheliopathy, persisting viral reservoirs, and autoimmune inflammation have been proposed . However, indirect, nonspecific stressors during the pandemic, such as fear of viral transmission, societal lockdown, and parents experiencing PCC, have also been suggested …”

Section: Introductionmentioning

confidence: 99%

“…6,[15][16][17][18][19] However, indirect, nonspecific stressors during the pandemic, such as fear of viral transmission, societal lockdown, and parents experiencing PCC, have also been suggested. 6,[20][21][22][23][24] Studies of PIFS have benefitted from an international case definition 25 that is centered around the symptom of fatigue, which should be persistent from onset of the acute infectious event, severely affect daily activities, and not be caused by any other condition; diagnosed individuals must experience at least 4 of 8 additional symptoms (such as headache and concentration or memory problems). In contrast, the broad case definition of PCC established by the World Health Organization (WHO) encompasses any symptom occurring in the aftermath of acute COVID-19, does not require symptom persistence since the infectious event, and does not stipulate significant disability.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Characteristics Associated With Post–COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults

et al. 2023

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ImportanceThe prevalence and baseline risk factors of post–COVID-19 condition (PCC) remain unresolved among the large number of young people who experienced mild COVID-19.ObjectivesTo determine the point prevalence of PCC 6 months after the acute infection, to determine the risk of development of PCC adjusted for possible confounders, and to explore a broad range of potential risk factors.Design, Setting, and ParticipantsThis cohort study included nonhospitalized individuals from 2 counties in Norway between ages 12 and 25 years who underwent reverse transcription–polymerase chain reaction (RT-PCR) testing. At the early convalescent stage and at 6-month follow-up, participants underwent a clinical examination; pulmonary, cardiac, and cognitive functional testing; immunological and organ injury biomarker analyses; and completion of a questionnaire. Participants were classified according to the World Health Organization case definition of PCC at follow-up. Association analyses of 78 potential risk factors were performed.ExposuresSARS-CoV-2 infection.Main Outcomes and MeasuresThe point prevalence of PCC 6 months after RT-PCR testing in the SARS-CoV-2–positive and SARS-CoV-2–negative groups, and the risk difference with corresponding 95% CIs.ResultsA total of 404 individuals testing positive for SARS-CoV-2 and 105 individuals testing negative were enrolled (194 male [38.1%]; 102 non-European [20.0%] ethnicity). A total of 22 of the SARS-CoV-2–positive and 4 of the SARS-CoV-2–negative individuals were lost to follow-up, and 16 SARS-CoV-2–negative individuals were excluded due to SARS-CoV-2 infection in the observational period. Hence, 382 SARS-CoV-2–positive participants (mean [SD] age, 18.0 [3.7] years; 152 male [39.8%]) and 85 SARS-CoV-2–negative participants (mean [SD] age, 17.7 [3.2] years; 31 male [36.5%]) could be evaluated. The point prevalence of PCC at 6 months was 48.5% in the SARS-CoV-2–positive group and 47.1% in the control group (risk difference, 1.5%; 95% CI, −10.2% to 13.1%). SARS-CoV-2 positivity was not associated with the development of PCC (relative risk [RR], 1.06; 95% CI, 0.83 to 1.37; final multivariable model utilizing modified Poisson regression). The main risk factor for PCC was symptom severity at baseline (RR, 1.41; 95% CI, 1.27-1.56). Low physical activity (RR, 0.96; 95% CI, 0.92-1.00) and loneliness (RR, 1.01; 95% CI, 1.00-1.02) were also associated, while biological markers were not. Symptom severity correlated with personality traits.Conclusions and RelevanceThe persistent symptoms and disability that characterize PCC are associated with factors other than SARS-CoV-2 infection, including psychosocial factors. This finding raises questions about the utility of the World Health Organization case definition and has implications for the planning of health care services as well as for further research on PCC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence and Characteristics Associated With Post–COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults

et al. 2023

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“…Coupled with the constant threat posed by the virus itself, particularly prior to vaccine development, these alterations fostered significant uncertainty and anxiety for many people (Paredes et al, 2021). Moreover, among those who contracted COVID, changes to physical health and overall wellness resulted from both the acute infection and the effects of long COVID or post-acute sequelae of COVID-19 illness (PASC) (Burton et al, 2022; Frontera et al, 2022; World Health Organization, 2021). Many affected by these conditions have described changes in capacity for both physical and mental activities; “brain fog” or cognitive impairment is among the most reported symptoms of PASC (Callan et al, 2021; Ceban et al, 2021).…”

Section: Results/exemplarsmentioning

confidence: 99%

Sociolocation: A Proposed Conceptual Element in Lifespan Development

Burton

2023

Clin Nurs Res

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Individual identity as a function of human development significantly intersects with and is necessarily influenced by the social world. To describe this intersection and its effects, the term sociolocation was proposed, initially in the context of adolescent development, and defined as “self-identification and recognition of social integration through relationships.” Almost a decade later, it is apparent that the processes of sociolocation may continue and repeat through the rest of the lifespan. The purpose of this, therefore, paper is to present an expanded definitional and conceptual analysis of sociolocation using the techniques described by Chinn, Kramer, and Sitzman. Such an analysis is important across nursing science, practice, and education, since in all three domains the nurse may encounter individuals engaged in sociolocation. Understanding what this process is and when and how it may occur can be helpful in care planning, learning, and research endeavors.

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“…More importantly, females appear to have worse post COVID outcomes associated with life stressors that may translate in to greater complications among those with long COVID symptomology. 27 …”

Section: Discussionmentioning

confidence: 99%

Racial, ethnic, and sex disparities in the incidence and cognitive symptomology of long COVID-19

Jacobs

Evans

Ellis

2023

Journal of the National Medical Association

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Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization

Cited by 20 publications

References 65 publications

Prevalence and Characteristics Associated With Post–COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults

Prevalence and Characteristics Associated With Post–COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults

Sociolocation: A Proposed Conceptual Element in Lifespan Development

Racial, ethnic, and sex disparities in the incidence and cognitive symptomology of long COVID-19

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