Life span extension in Drosophila melanogaster induced by morphine

Dubiley, T. A.; Rushkevich, Yu. E.; Koshel, N. M.; Voitenko, V. P.; Vaiserman, Alexander

doi:10.1007/s10522-010-9308-1

Cited by 11 publications

(3 citation statements)

References 39 publications

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“…MH supplementation on the 5th day after birth obviously prolonged the average lifespan of male flies at all studied concentrations. The female fruit flies treated with only 0.25 mg/mL MH lived significantly longer than the control group [ 31 ]. Together with earlier studies in mice, [ 32 ] morphine supplementation was found to extend life span in vertebrates and invertebrates.…”

Section: Natural Products As Antiaging Agentsmentioning

confidence: 99%

Antiaging agents: safe interventions to slow aging and healthy life span extension

Liu

2022

Nat. Prod. Bioprospect.

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Human longevity has increased dramatically during the past century. More than 20% of the 9 billion population of the world will exceed the age of 60 in 2050. Since the last three decades, some interventions and many preclinical studies have been found to show slowing aging and increasing the healthy lifespan of organisms from yeast, flies, rodents to nonhuman primates. The interventions are classified into two groups: lifestyle modifications and pharmacological/genetic manipulations. Some genetic pathways have been characterized to have a specific role in controlling aging and lifespan. Thus, all genes in the pathways are potential antiaging targets. Currently, many antiaging compounds target the calorie-restriction mimetic, autophagy induction, and putative enhancement of cell regeneration, epigenetic modulation of gene activity such as inhibition of histone deacetylases and DNA methyltransferases, are under development. It appears evident that the exploration of new targets for these antiaging agents based on biogerontological research provides an incredible opportunity for the healthcare and pharmaceutical industries. The present review focus on the properties of slow aging and healthy life span extension of natural products from various biological resources, endogenous substances, drugs, and synthetic compounds, as well as the mechanisms of targets for antiaging evaluation. These bioactive compounds that could benefit healthy aging and the potential role of life span extension are discussed.

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Section: Natural Products As Antiaging Agentsmentioning

confidence: 99%

Antiaging agents: safe interventions to slow aging and healthy life span extension

Liu

2022

Nat. Prod. Bioprospect.

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“…Despite its undesirable effects, such as respiratory depression and physical dependence, morphine has been identified as crucial in protecting against post-traumatic stress. Additionally, it stimulates the growth and regeneration of nervous fibers and has also been found to increase the lifespan of Drosophila flies [76]. In a study, male and female Oregon-R flies were given morphine hydrochloride once a week at a dosage range of 0.001-0.25 mg•mL −1 , which resulted in an extended lifespan [50].…”

Section: Development and Lifespanmentioning

confidence: 99%

Drosophila melanogaster as a Translational Model System to Explore the Impact of Phytochemicals on Human Health

Lopez-Ortiz,

Gracia-Rodriguez,

Belcher

et al. 2023

IJMS

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Fruits, vegetables, and spices are natural sources of bioactive phytochemicals, such as polyphenols, carotenoids, flavonoids, curcuminoids, terpenoids, and capsaicinoids, possessing multiple health benefits and relatively low toxicity. These compounds found in the diet play a central role in organism development and fitness. Given the complexity of the whole-body response to dietary changes, invertebrate model organisms can be valuable tools to examine the interplay between genes, signaling pathways, and metabolism. Drosophila melanogaster, an invertebrate model with its extensively studied genome, has more than 70% gene homology to humans and has been used as a model system in biological studies for a long time. The notable advantages of Drosophila as a model system, such as their low maintenance cost, high reproductive rate, short generation time and lifespan, and the high similarity of metabolic pathways between Drosophila and mammals, have encouraged the use of Drosophila in the context of screening and evaluating the impact of phytochemicals present in the diet. Here, we review the benefits of Drosophila as a model system for use in the study of phytochemical ingestion and describe the previously reported effects of phytochemical consumption in Drosophila.

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“…Previous studies have attempted to verify the life span-extending effects of these reagents using model animals such as D. melanogaster. Morphine, widely known as an narcotic analgesic extracted from opium poppies, reportedly extends the life span of D. melanogaster (Dubiley et al 2011). Specifically, exposure to morphine hydrochloride at 0.01-0.25 mg/mL once per week increased the mean life span of Oregon-R male and female flies.…”

Section: Othersmentioning

confidence: 99%

Life Extension

Bourg

2015

Healthy Ageing and Longevity

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Life span extension in Drosophila melanogaster induced by morphine

Cited by 11 publications

References 39 publications

Antiaging agents: safe interventions to slow aging and healthy life span extension

Antiaging agents: safe interventions to slow aging and healthy life span extension

Drosophila melanogaster as a Translational Model System to Explore the Impact of Phytochemicals on Human Health

Life Extension

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