Life-span cognitive activity, neuropathologic burden, and cognitive aging

Wilson, Robert S.; Boyle, Patricia A.; Yu, Lei; Barnes, Lisa L.; Schneider, Julie A.; Bennett, David A.

doi:10.1212/wnl.0b013e31829c5e8a

Cited by 229 publications

(222 citation statements)

References 42 publications

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“…Review of the literature confirms the above clinical findings.Cognitively stimulating activities has been associated with reduced late life cognitive decline in the aged population documented in a number of recent studies [1][2][3][4][5][6]. Cognitive stimulation throughout the lifespan has been seen as a protector against cognitive decline despite the onset of neuropathological conditions.It is also common for those afflicted with neurocognitive decline to restrict their activities leading to the cascade of poor sleep, food intake and physical inactivity.These are the two proposed mechanisms suggested as explanatory factors for those individuals who age gracefully versus those who reveal debilitating decline; the cognitive reserve hypothesis [6][7][8] and the reverse causality hypothesis [2,9].…”

Section: Introductionmentioning

confidence: 99%

“…The study by Wilson et al [1] used a longitudinal clinical pathologic cohort study with the availability of neuropathologic measures of amyloid burden, tangle density, gross cerebral infarcts, microscopic cerebral infarcts and neocortical Lewy bodies allowing the authors to rule in the cognitive reserve hypothesis.Engagement in cognitively stimulating activities (early and late) slowed cognitive decline accounting for 14 percent of the residual variability (in cognitive decline) independent and beyond what would be explained by the neuropathology.Both frequent current and early life engagement in cognitively stimulating activities were shown to independently slow late life cognitive decline.…”

Section: Introductionmentioning

confidence: 99%

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The Benefits of Cognitive Stimulation or Training/Rehabilitation upon Brain Function as an Efficacious Treatment for Diagnosed Dementia or Mild Cognitive Decline

Fisher¹

2014

J Alzheimers Dis Parkinsonism

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Medication has had disappointing results seen in various recently failed drug trials.The role of medication has typically been more preventative as opposed to providing evidence of improved memory function reported by cognitive rehabilitation research. The interest held by our facility is based upon fifteen years of providing cognitive training and seeing some type of improvement in every patient following as minimal as three months of training (twice weekly for one hour).Differences are seen on neuropsychological evaluation completed prior to training and following three month treatment intervals.We employ the use of various games and activities that are specifically chosen based upon neurocognitive assessment.As a result this is not a broad based program but instead a specifically designed individualized treatment for various forms of dementia.This is consistent with a literature review of cognitive stimulation or rehabilitation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Benefits of Cognitive Stimulation or Training/Rehabilitation upon Brain Function as an Efficacious Treatment for Diagnosed Dementia or Mild Cognitive Decline

Fisher¹

2014

J Alzheimers Dis Parkinsonism

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“…La reserva cognitiva es una variable que se va modificando a lo largo de la vida, se comienza a desarrollar en la primera infancia y se va ampliando a lo largo del ciclo vital (Wilson, et al 2013). El hecho de que sea modificable y su relación, aunque débil, con la menor sintomatología depresiva durante el envejecimiento; invita a considerar la necesidad de desarrollar acciones que contribuyan a fortalecerla.…”

Section: Conclusionesunclassified

La reserva cognitiva como posible factor protector ante los trastornos del estado de ánimo en la vejez.

Sintes¹

2018

Revista INFAD de Psicología

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RESUMEN:En el período de envejecimiento se produce una situación de atrofia y muerte neuronal lo cual ocasiona que algunas funciones cognitivas puedan verse afectadas cuando la persona se hace mayor. El cerebro humano tiene la capacidad de cambiar de estructura y función en respuesta a mecanismos internos o externos, mecanismos que se engloban dentro del constructo denominado reserva cognitiva.El objetivo de esta comunicación es profundizar sobre este constructo, analizar las diferencias del mismo por grupo de edad, y estudiar su posible relación con la reducción de la incidencia de la depresión en los adultos mayores, la cual consitituye uno de los problemas de salud mental más relevante en esa etapa del ciclo vital.Los resultados muestran que la reserva cognitiva se relaciona con una menor incidencia de sín-tomas depresivos en los adultos mayores, y que dentro de éstos, los menores de 75 años presentan una reserva cognitiva más fuerte que los que superan esa edad.Palabras clave: Envejecimiento, reserva cognitiva, depresión. ABSTRACT:Atrophy and death of neurons occur during the ageing period, which may cause certain cognitive functions to be affected when a person gets old. The human brain has the ability to change its structure and function by answering to internal and external mechanisms, which comprise the construct called cognitive reserve.The purpose of this paper is: to delve into this construct; to analyse its differences according to age group; and to study the possible connection between this construct and the reduction of incidence of depression in older adults. Depression constitutes one the most relevant mental health problems in that stage of the life cycle.

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“…However, the underlying mechanisms of the relationship between better cognitive function and frequent social interaction are still unclear [51][52][53]. Additional studies revealed that remaining social and cognitive engagement throughout life may affect biological processes and support brain health and reduce the risk of AD [54][55][56][57][58][59][60] but the exact mechanism by which this may occur is unknown [61].…”

Section: Alzheimer's Disease Risk Factorsmentioning

confidence: 99%

Risk Factors in Induction and Progression of Alzheimer’s Disease: Impacton Protection and Disease-Modifying Factors

Ali¹

2017

Brain Disord Ther

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to memory loss and nerve cell death throughout the brain. It is the most common cause of dementia and represents the most important problem in elderly. Dementia characterized mainly by decline in memory, cognitive skills and ability to perform everyday activities as well as behavioral dysfunction. The decline occurs because neurons involved in cognitive function have been destroyed and affected other parts of the brain involved in different basic bodily functions.

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Life-span cognitive activity, neuropathologic burden, and cognitive aging

Abstract: More frequent cognitive activity across the life span has an association with slower late-life cognitive decline that is independent of common neuropathologic conditions, consistent with the cognitive reserve hypothesis.

Cited by 229 publications

References 42 publications

The Benefits of Cognitive Stimulation or Training/Rehabilitation upon Brain Function as an Efficacious Treatment for Diagnosed Dementia or Mild Cognitive Decline

The Benefits of Cognitive Stimulation or Training/Rehabilitation upon Brain Function as an Efficacious Treatment for Diagnosed Dementia or Mild Cognitive Decline

La reserva cognitiva como posible factor protector ante los trastornos del estado de ánimo en la vejez.

Risk Factors in Induction and Progression of Alzheimer’s Disease: Impacton Protection and Disease-Modifying Factors

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