Life span, cancer and non-cancer diseases in mouse exposed to a continuous very low dose of γ-irradiation.

Courtade, M; Billotet, C.; Gasset, G.; Caratero, A; Charlet, Jean-Paul; Pipy, Bernard; Caratero, C

doi:10.1080/09553000210151639

Cited by 20 publications

(13 citation statements)

References 27 publications

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“…In a previous study, we have shown that HS incidence in C57BL/6J female mice was reduced by administration of chronic lowdose irradiation (4). During this study, we obtained 41 cases of HS in nontreated mice, for which we were aware of unexpected associated hematopoietic disorders.…”

Section: Introductionmentioning

confidence: 89%

Histiocytic Sarcoma in C57BL/6J Female Mice is Associated with Liver Hematopoiesis: Review of 41 Cases

et al. 2003

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Forty-one cases of histiocytic sarcoma (HS) in C57BL/6J mice were histopathologically studied with special regard to unexpected associated hematopoietic disorders. These cases were retrieved among C57BL/6J female mice used as control mice in a chronic low-dose irradiation experiment. Hematopoietic characteristics were analysed by comparison to 41 disease-free mice from the same cohort. Tumoral involvement of the liver was observed in all 41 HS-bearing mice, followed by infiltration of the spleen (61.8%), lung (32.4%), bone marrow (14.3%), uterus (12.2%), lymph node (9.8%), and kidney (2.4%). By comparative analysis, we were able to demonstrate a significant association of HS with liver hematopoiesis (89.5% in HS group vs 15% in control mice, p < 0.00001), and with central hematopoietic disorders involving the myelocytic cells (decreased in HS, p = 0.003) and erythrocytic cells (increased in HS, p = 0.001). Microscopic characteristics of these 41 cases and physiopathology of the newly described hematopoietic features in HS are further discussed.

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Section: Introductionmentioning

confidence: 89%

Histiocytic Sarcoma in C57BL/6J Female Mice is Associated with Liver Hematopoiesis: Review of 41 Cases

et al. 2003

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“…For several years, we have perfected a unique model of chronic irradiation to γ-rays able to deliver a continuous low-dose rate irradiation of 10cGy/year. Life-long irradiation of C57Bl/6J female mice was responsible for a delay of death by lymphoma ( Courtade et al . 2002 ) although it had no effect on life span.…”

Section: Introductionmentioning

confidence: 99%

Influence of a Continuous Very Low Dose of Gamma-Rays on Cell Proliferation, Apoptosis and Oxidative Stress

et al. 2014

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We have previously shown a delay of death by lymphoma in SJL/J mice irradiated with continuous very low doses of ionizing radiation. In order to understand the mechanisms involved in this phenomenon, we have irradiated in vitro the Raw264.7 monocytic and the YAC-1 lymphoma cell lines at very low-dose rate of 4cGy.month-1. We have observed a transient increase in production of both free radicals and nitric oxide with a transient adaptive response during at least two weeks after the beginning of the irradiation. The slight decrease of Ki67 proliferation index observed during the second and third weeks of YAC-1 cells culture under irradiation was not significant but consistent with the shift of the proliferation assay curves of YAC-1cells at these same durations of culture. These in vitro results were in good agreement with the slightly decrease under irradiation of Ki67 proliferative index evaluated on lymphomatous lymph nodes of SJL/J mice. A significant decrease of YAC-1 cells apoptotic rate under radiation appeared after 4 weeks of culture.Therefore very small doses of gamma-irradiation are able to modify the cellular response. The main observations did not last with increasing time under irradiation, suggesting a transient adaptation of cells or organisms to this level of irradiation.

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“…Moreover, fractionated low dose radiation over a period of several weeks has been shown to increase the number of T-regulatory cells (Tago et al 2008; Tsukimoto et al 2008). Radiation-induced up-regulation of antiinflammatory immune cells has been associated with a lower frequency of lymphomas (Courtade et al 2002; Ina et al 2005; Lacoste-Collin et al 2007; Mitchel 2007; Nakatsukasa et al 2008; Tago et al 2008; Tsukimoto et al 2008; Tsuruga et al 2007). In contrast, however, a higher frequency of hematological malignancies and chromosome aberrations has been reported in mice and dogs after continuous low dose-rate irradiation (Seed et al 2002a, 2002b; Tanaka et al 2007, 2008, 2009).…”

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confidence: 99%

Integrated Molecular Analysis Indicates Undetectable Change in DNA Damage in Mice after Continuous Irradiation at ~ 400-fold Natural Background Radiation

Olipitz

Wiktor-Brown

Shuga

et al. 2012

Environ Health Perspect

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Background: In the event of a nuclear accident, people are exposed to elevated levels of continuous low dose-rate radiation. Nevertheless, most of the literature describes the biological effects of acute radiation.Objectives: DNA damage and mutations are well established for their carcinogenic effects. We assessed several key markers of DNA damage and DNA damage responses in mice exposed to low dose-rate radiation to reveal potential genotoxic effects associated with low dose-rate radiation.Methods: We studied low dose-rate radiation using a variable low dose-rate irradiator consisting of flood phantoms filled with 125Iodine-containing buffer. Mice were exposed to 0.0002 cGy/min (~ 400-fold background radiation) continuously over 5 weeks. We assessed base lesions, micronuclei, homologous recombination (HR; using fluorescent yellow direct repeat mice), and transcript levels for several radiation-sensitive genes.Results: We did not observe any changes in the levels of the DNA nucleobase damage products hypoxanthine, 8-oxo-7,8-dihydroguanine, 1,N6-ethenoadenine, or 3,N4-ethenocytosine above background levels under low dose-rate conditions. The micronucleus assay revealed no evidence that low dose-rate radiation induced DNA fragmentation, and there was no evidence of double strand break–induced HR. Furthermore, low dose-rate radiation did not induce Cdkn1a, Gadd45a, Mdm2, Atm, or Dbd2. Importantly, the same total dose, when delivered acutely, induced micronuclei and transcriptional responses.Conclusions: These results demonstrate in an in vivo animal model that lowering the dose-rate suppresses the potentially deleterious impact of radiation and calls attention to the need for a deeper understanding of the biological impact of low dose-rate radiation.

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Life span, cancer and non-cancer diseases in mouse exposed to a continuous very low dose of γ-irradiation.

Abstract: Continuous 10 cGy year(-1) gamma-irradiation had no adverse effect on malignant or non-malignant diseases in this strain of mouse.

Cited by 20 publications

References 27 publications

Histiocytic Sarcoma in C57BL/6J Female Mice is Associated with Liver Hematopoiesis: Review of 41 Cases

Histiocytic Sarcoma in C57BL/6J Female Mice is Associated with Liver Hematopoiesis: Review of 41 Cases

Influence of a Continuous Very Low Dose of Gamma-Rays on Cell Proliferation, Apoptosis and Oxidative Stress

Integrated Molecular Analysis Indicates Undetectable Change in DNA Damage in Mice after Continuous Irradiation at ~ 400-fold Natural Background Radiation

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