Life-span alterations in visually evoked potentials and inhibitory function

Dustman, Robert E.; Snyder, Edward W.; Schlehuber, C

doi:10.1016/0197-4580(81)90019-1

Cited by 43 publications

(9 citation statements)

References 26 publications

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“…This result was confirmed in later studies that also demonstrated that amplitude0intensity slopes of VEPs from frontocentral areas of children were larger than those of young adults~Dustman, Shearer, & Emmerson, 1993;Dustman, Snyder, & Schlehuber, 1981!. However, results from a study using auditory stimuli~Bruneau, Roux, Guérin, Barthélémy, & Lelord, 1997!…”

supporting

confidence: 76%

The effects of stimulus intensity and age on visual‐evoked potentials (VEPs) in normal children

et al. 1999

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In this study, we explored the effects of flash intensity and age on visual-evoked potentials (VEPs) in a sample of 85 children aged 8-15 years. Results of previous studies are discrepant regarding the extent to which children show an evoked potential augmenting tendency at vertex, which has been reported to be a characteristic of an immature inhibitory control system. In the present study, VEPs to light flashes of four different intensities were recorded at Cz. The results confirmed that P1N1 and N1P2 at Cz were positively related to increases in stimulus intensity, whereas N1 was not related reliably to intensity. This difference between peak-peak and baseline-peak amplitude findings at Cz relative to evoked potential augmenting and reducing may help to explain discrepant results among earlier studies. Developmental changes were found for our sample of children that were independent of stimulus intensity: N1 amplitude increased significantly with age, whereas N1 latency showed a small (nonsignificant) age-related decrease.

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confidence: 76%

The effects of stimulus intensity and age on visual‐evoked potentials (VEPs) in normal children

et al. 1999

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“…Our study and others (Friedman et al, 1999; Skeel et al, 2003) indicate that this kind of reporting may not be accurate. Because of absent documentation, it is impossible to ascertain the degree to which the visual acuity of subjects differed across studies, or contributed to the marked variability in reports of age-related differences in P1 and N1, especially in terms of amplitude (Celesia and Daly, 1977; Ceponiene et al, 2008; Curran et al, 2001; Czigler and Balazs, 2005; De Sanctis et al, 2008; Diaz and Amenedo, 1998; Dustman et al, 1981; Dustman and Beck, 1966; Dustman and Snyder, 1981; Falkenstein et al, 2006; Finnigan et al, 2011; Kolev et al, 2006; Kutas et al, 1994; Yordanova et al, 2004; Zanto et al, 2010). 6 …”

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confidence: 99%

The impact of visual acuity on age-related differences in neural markers of early visual processing

et al. 2013

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The extent to which age-related differences in neural markers of visual processing are influenced by changes in visual acuity has not been systematically investigated. Studies often indicate that their subjects had normal or corrected-to-normal vision, but the assessment of visual acuity seems to most frequently be based only on self-report. Consistent with prior research, to be included in the current study, subjects had to report normal or corrected-to-normal vision. Additionally, visual acuity was formally tested using a Snellen eye chart. Event-related potentials (ERPs) were studied in young adults (18–32 years old), young-old adults (65–79 years old), and old-old adults (80+ years old) while they performed a visual processing task involving selective attention to color. Age-related differences in the latency and amplitude of ERP markers of early visual processing, the posterior P1 and N1 components, were examined. All results were then re-analyzed after controlling for visual acuity. We found that visual acuity declined as a function of age. Accounting for visual acuity had an impact on whether older and younger adults differed significantly in the size and latency of the posterior P1 and N1 components. After controlling for visual acuity, age-related increases in P1 and N1 latency did not remain significant, and older adults were found to have a larger P1 amplitude than young adults. Our results suggest that until the relationship between age-associated differences in visual acuity and early ERPs is clearly established, investigators should be cautious when interpreting the meaning of their findings. Self-reports about visual acuity may be inaccurate, necessitating formal measures. Additional investigation is needed to help establish guidelines for future research, especially of very old adults.

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“…Indeed, morphology studies have observed a selective decline in presumptive inhibitory synapses in the sensorimotor cortex of aged rats (Brunso-Bechtold et al, 2000). Moreover, electrophysiological findings by Dustman et al have suggested that there is weakened inhibition in elderly people (Dustman and Snyder, 1981; Dustman et al, 1981; Dustman et al, 1985; Dustman et al, 1996). For example, evoked potential studies revealed that the inhibitory activity of neurons was negatively affected in the visual cortex as well as some other sensory cortices of humans (Dustman et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

The effects of aging on the strength of surround suppression of receptive field of V1 cells in monkeys

Wang

et al. 2010

Neuroscience

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The surround suppression of the receptive field is important for basic visual information processing, such as orientation specificity. To date, the effects of aging on the strength of surround suppression are not clear. To address this issue, we carried out extracellular single-unit studies of the receptive field properties of cells in the primary visual cortex (area V1) in young and old rhesus (Macaca mulatta) monkeys. When presented with the oriented central stimulus, we found that cells in old animals showed reduced orientation and direction selectivity compared with those in young animals. When presented with the oriented central stimulus together with the optimal surround stimulus, more selective cells {orientation bias (OB) ≥ 0.1; a bias of 0.1 is significant at the P < 0.005 level} in animals of both ages showed reduced orientation selectivity compared with the experiment that presented only the oriented central stimulus. When presented with the optimal central stimulus together with the oriented surround stimulus, cells in old animals showed reduced orientation and direction selectivity compared with young animals. Moreover, broadly tuned cells (OB<0.1) in old animals exhibited significantly reduced suppression indices that quantified the strength of the surround suppression of the receptive field, when compared with those in young animals. These results suggest that aging may seriously affect the surround suppression of the receptive field of V1 cells. Thus, the decreased strength of surround suppression of the receptive field may be one possible reason for the decreased stimulus selectivity of V1 cells previously Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. found in the senescent brain. This work will contribute to an understanding of the physiological mechanisms mediating surround suppression of the receptive field. NIH Public Access

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Life-span alterations in visually evoked potentials and inhibitory function

Cited by 43 publications

References 26 publications

The effects of stimulus intensity and age on visual‐evoked potentials (VEPs) in normal children

The effects of stimulus intensity and age on visual‐evoked potentials (VEPs) in normal children

The impact of visual acuity on age-related differences in neural markers of early visual processing

The effects of aging on the strength of surround suppression of receptive field of V1 cells in monkeys

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