Life science research using positron annihilation spectroscopy: UV-irradiated mouse skin

Jean, Y. C.; Chen, Hongmin; Liu, Guang; Gadzia, Joseph

doi:10.1016/j.radphyschem.2006.03.008

Cited by 17 publications

(10 citation statements)

References 23 publications

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“…29 There are investigations demonstrating differences between normal and cancerous cells with changes of the positronium lifetime during dynamic processes undergoing in model and living biological systems. [79][80][81][85][86][87][88][89][90][91][92][93][94][95] Therefore, positronium may be used as a sensor of the surrounding tissue environment, and imaging of its properties inside the patient body may serve as additional diagnostic indicator. In general, positronium imaging can be defined as a method for the position-sensitive reconstruction of positronium properties (such as mean lifetime, formation probability, and 3g/2g rate ratio) within the imaged object.…”

Section: Positronium Imagingmentioning

confidence: 99%

Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators

2020

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Total-body PET opens a new diagnostic paradigm with prospects for personalized disease treatment, yet the high cost of the current crystal-based PET technology limits dissemination of totalbody PET in hospitals and even in the research clinics. The J-PET tomography system is based on axially arranged low-cost plastic scintillator strips. It constitutes a realistic cost-effective solution of a total-body PET for broad clinical applications. High sensitivity of total-body J-PET and triggerless data acquisition enable multiphoton imaging, opening possibilities for multitracer and positronium imaging, thus promising quantitative enhancement of specificity in cancer and inflammatory diseases assessment. An example of dual tracer analysis, becoming possible with total-body J-PET system, could be a concurrent application of Food and Drug Administration-approved 82 Rb-Chloride and [ 18 F]FDG, allowing simultaneous assessment of myocardium metabolic rate and perfusion of the cardiovascular system.

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Section: Positronium Imagingmentioning

confidence: 99%

Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators

2020

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“…As a result, it can provide information about the disease progression in an initial stage (14). Several studies have investigated the changes of the positronium properties during dynamic processes while applying model and living biological systems (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). It has been found that there are differences in the positronium mean lifetimes and the production probabilities in healthy and cancerous tissues, indicating that these parameters can be used as indicators for in vivo cancer classification.…”

Section: Introductionmentioning

confidence: 99%

Positronium imaging with the novel multiphoton PET scanner

et al. 2021

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In vivo assessment of cancer and precise location of altered tissues at initial stages of molecular disorders are important diagnostic challenges. Positronium is copiously formed in the free molecular spaces in the patient's body during positron emission tomography (PET). The positronium properties vary according to the size of inter-and intramolecular voids and the concentration of molecules in them such as, e.g., molecular oxygen, O 2 ; therefore, positronium imaging may provide information about disease progression during the initial stages of molecular alterations. Current PET systems do not allow acquisition of positronium images. This study presents a new method that enables positronium imaging by simultaneous registration of annihilation photons and deexcitation photons from pharmaceuticals labeled with radionuclides. The first positronium imaging of a phantom built from cardiac myxoma and adipose tissue is demonstrated. It is anticipated that positronium imaging will substantially enhance the specificity of PET diagnostics.

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“…However, the pioneering experiments on ex vivo samples showing that small temperature variations cause detectable changes in free voids were done on bovine liver and rabbit muscle (Elias et al, 2001). To develop technical details of o-Ps measurements, a number of experiments were performed on human and mice skin to study differences in the mean τ o−P s of normal cells and cancer (basal cell carcinoma and squamous cell carcinoma) (Jean et al, 2007(Jean et al, , 2006. This approach appeared to be promising and indicated a reduction of free volume at the molecular level for the skin with cancer while the number of patients was the limitation to conclude about usefulness of positronium imaging in cancer diagnostics (Liu et al, 2007).…”

Section: B Positronium In Ex Vivo Researchmentioning

confidence: 99%

Positronium Physics and Biomedical Applications

Bass¹,

Mariazzi²,

Moskal³

et al. 2023

Preprint

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Positronium is the simplest bound state, built of an electron and a positron. Studies of positronium in vacuum and its decays in medium tell us about Quantum Electrodynamics, QED, and about the structure of matter and biological processes of living organisms at the nanoscale, respectively. Spectroscopic measurements constrain our understanding of QED bound state theory. Searches for rare decays and measurements of the effect of gravitation on positronium are used to look for new physics phenomena. In biological materials positronium decays are sensitive to the inter-and intra-molecular structure and to the metabolism of living organisms ranging from single cells to human beings. This leads to new ideas of positronium imaging in medicine using the fact that during positron emission tomography (PET) as much as 40% of positron annihilation occurs through the production of positronium atoms inside the patient's body. A new generation of the high sensitivity and multi-photon total-body PET systems opens perspectives for clinical applications of positronium as a biomarker of tissue pathology and the degree of tissue oxidation.

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Life science research using positron annihilation spectroscopy: UV-irradiated mouse skin

Cited by 17 publications

References 23 publications

Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators

Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators

Positronium imaging with the novel multiphoton PET scanner

Positronium Physics and Biomedical Applications

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