Life’s Essential 8, genetic predisposition, and risk of incident adult-onset asthma: a prospective cohort study

Zhang, Hehua; Chang, Qing; Yang, Honghao; Yu, Huixin; Chen, Liangkai; Zhao, Yuhong; Xia, Yang

doi:10.1016/j.ajcnut.2023.11.009

Cited by 4 publications

(1 citation statement)

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“…A recently updated cardiovascular health (CVH) concept proposed by the American Heart Association (AHA), known as Life’s Essential 8 (LE8) [ 6 ], has been identified as a potent predictor of risk of cardiovascular disease (CVD) and other chronic conditions, such as nonalcoholic fatty liver disease and asthma [ 7 – 10 ]. Based on the Life’s Simple 7, LE8 incorporates ideal health behaviors (less nicotine exposure, body mass index [BMI] < 25 kg/m 2 , ideal physical activity [PA], and healthy diets based on guideline recommendations) and health factors (normal levels of serum lipids, blood pressure [BP], and blood glucose), with the addition of sleep health [ 6 ].…”

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confidence: 99%

Life’s essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study

Yang,

Chang,

et al. 2024

Int J Behav Nutr Phys Act

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Background Evidence has shown that the individual metrics in Life’s Essential 8 (LE8), an updated cardiovascular health (CVH) concept proposed by the American Heart Association, play a role in the development of inflammatory bowel disease (IBD). However, epidemiological evidence on the overall LE8 on IBD risk remains limited. We aimed to assess the longitudinal associations of LE8-defined CVH and the risks of IBD and its subtypes, ulcerative colitis (UC) and Crohn’s disease (CD). We also tested whether genetic susceptibility could modify these associations. Methods A total of 260,836 participants from the UK Biobank were included. LE8 scores were determined by 8 metrics (physical activity, diet, nicotine exposure, sleep, body mass index, blood pressure, blood glucose, and blood lipids), and were divided into three levels: low CVH (0–49), moderate CVH (50–79), and high CVH (80–100). Cox proportional hazards models were used to calculate the hazard ratios (HRs) and confidence intervals (CIs) of the risk of IBD in relation to CVH status. Results Over a median follow-up 12.3 years, we documented 1,500 IBD cases (including 1,070 UC and 502 CD). Compared to participants with low CVH, the HRs (95% CIs) of those with high CVH for IBD, UC, and CD were 0.67 (0.52, 0.83), 0.70 (0.52, 0.93), and 0.55 (0.38, 0.80), respectively. These associations were not modified by genetic susceptibility (all P for interactions > 0.05). The lowest HR (UC: 0.30, 95% CI: 0.20–0.45; CD: 0.33, 95% CI: 0.20–0.57) was observed in participants with both high CVH and low genetic risk. Conclusions Better CVH, defined by LE8, was associated with significantly lower risks of IBD, UC, and CD, irrespective of genetic predisposition. Our results underscore the importance of adherence to LE8 guidelines for maintaining CVH as a potential strategy in the prevention of IBD.

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Section: Introductionmentioning

confidence: 99%

Life’s essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study

Yang,

Chang,

et al. 2024

Int J Behav Nutr Phys Act

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Associations Between Life's Essential 8 and Major Ocular Diseases in the American Middle-Aged and Elderly Population

Yang,

Zhang,

Zheng

2024

American Journal of Ophthalmology

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Life’s Essential 8, genetic susceptibility and the risk of psoriatic disease: a prospective cohort study

Ouyang,

Yang,

et al. 2024

British Journal of Dermatology

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Background Psoriatic disease (PsD) is closely associated with cardiovascular diseases. The Life's Essential 8 (LE8) score is a new metric for assessing cardiovascular health (CVH), where a higher score indicates better CVH. However, the longitudinal association between LE8 score and the risk of PsD remains uncertain. The main aim of the present study was to explore the association between LE8 scores and the risk of PsD. Objective To investigate the associations between LE8 score, genetic susceptibility, and the risk of PsD within a cohort design. Methods This cohort study included 261,642 participants from the UK Biobank without PsD at baseline. LE8 comprises eight indicators: diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, and blood pressure. Cox proportional hazard models were employed to examine the association between the participants’ LE8 scores, PsD genetic risk, and the risk of PsD. Hazard ratios (HRs) and 95% confidential intervals (CIs) were calculated. Results During an average follow-up of 12.32 years, 1,501 participants developed PsD. Compared to participants with low LE8 scores, the HRs (95% CIs) of developing PsD for those with moderate and high LE8 scores were 0.51 (0.43, 0.59) and 0.34 (0.27, 0.42) after adjustments, respectively. Dose-response analysis revealed a linear negative association between continuous LE8 score and the risk of developing PsD (P < 0.001), with no evidence of non-linear association detected. The genetic susceptibility to PsD did not modify this association (P for interaction = 0.63). Subgroup analyses revealed that women demonstrated a more pronounced beneficial association between LE8 scores and PsD risk (P for interaction = 0.02). Conclusions Our study suggests that a higher LE8 score, regardless of genetic risk, was associated with a lower risk of PsD, particularly among women. Consequently, maintaining a high CVH status is recommended to prevent PsD and assess associated risks.

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Life’s Essential 8, genetic predisposition, and risk of incident adult-onset asthma: a prospective cohort study

Cited by 4 publications

References 46 publications

Life’s essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study

Life’s essential 8, genetic susceptibility, and risk of inflammatory bowel diseases: a population-based cohort study

Associations Between Life's Essential 8 and Major Ocular Diseases in the American Middle-Aged and Elderly Population

Life’s Essential 8, genetic susceptibility and the risk of psoriatic disease: a prospective cohort study

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