The current study aimed to analyze the path of causal relationships between each of the ability to tolerance/ intolerance ambiguity, orientation towards life, coping styles, and psychological resilience in a sample of medical staff (236) (65) males, and (173) females. The study tools were applied to them (tolerance/intolerance of ambiguity scale, life orientation scale, a measure of coping styles scale, and resilience scale) prepared by the researchers and using the statistical program SPSS and AMOS. The data were analyzed using the structural modeling equation, and path analysis to validate the model. The proposal and the possibility of causal relationships between the variables of the study and the T. test for the significance of differences. The results indicated that there is a direct positive statistically significant effect of tolerance of ambiguity on effective coping styles; a direct, positive statistically significant effect of orientation towards life on effective coping styles; a direct, positive, statistically significant effect of effective coping styles on resilience; and a direct, statistically significant positive effect of tolerance of