Life History of Decidual Cells: A Review*

Kearns, Mary; Lala, Peeyush K.

doi:10.1111/j.1600-0897.1983.tb00219.x

Cited by 77 publications

(32 citation statements)

References 30 publications

(3 reference statements)

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“…Predecidual cells have been reported to have metabolic (21) and immunologic (18) functions. For example, they have phagocytotic properties and digest extracellular collagen matrix (21), and are also related to the maintenance of the fetal allograft (18).…”

Section: Discussionmentioning

confidence: 99%

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Immunohistochemical assessment of superoxide dismutase expression in the human endometrium throughout the menstrual cycle.

Narimoto

Noda

Shiotani

et al. 1990

Acta Histochem. Cytochem

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The immunohistochemical distribution of superoxide dismutase (SOD) was examined in the human endometrium throughout the menstrual cycle. Surface and glandular epithelia showed positive staining throughout the menstrual cycle except just prior to the menstruation.Staining activity was more intense in the cytoplasm than that in the nucleus. Specific immunostaining of SOD was demonstrated in sub-and supranuclear vacuoles of glandular epithelia, and intraglandular substances during the early and mid secretory phases; i.e., the preand peri-implantation periods. Meanwhile, stromal cells showed weaker staining activity than surface and glandular epithelia throughout the menstrual cycle until the 22th day. Once the predecidual change occurred in stromal cells on the 23th day, predecidual cells came to show intensive staining. However, specific staining was shown neither in predecidual cells nor in surface or glandular epithelia just prior to the menstruation. In addition, SOD activity was also shown in the decidual cells of 8 weeks gestation and in the reserve cells of the endocervix. Collectively, the present immunohistochemical recults suggest that SOD may play an important role not only in the protection of developing embryos from superoxide anion radicals but also in the local defense mechanism against tissue damages resulting from inflammation in the uterine cavity, and that the expression of SOD may be regulated by sex steroids, especially progestorone. Furthermore, SOD could be a useful indicator to clinically diagnose the degree of predecidualization and the luteal phase defect.The superoxide anion, a free radical generated during the monovalent metabolic reduction of oxygen, is toxic to the aerobic cell in which it is produced (13). The superoxide anion radical has been reported to damage cell membrane (22) and DNA (35), and to inactivate various enzymes (6). Also, it has been implicated in a variety of pathologic processes, including diabetes mellitus (11), lung damage (20), hepatitis (36), myocardial reperfusion injury following surgery (16), cataract (4), and so on. Therefore, effective detoxication of the superoxide anion radical appears to be a prerequisite for life in an oxygen-containing environment. Superoxide dismutase (SOD), known as superoxide oxidoreductase is an enzyme that catalyzes the dismutation (reduction/oxidation) of the superoxide anion radical in the following reaction: 2H+ +202 --k H202+02, and it is important as a biological defense mechanism against 487 488 Narimoto et al.cell injury mediated through superoxide anion radicals (12). In mammalians, three types of SOD have been identified which have different structures and metal contents: a cytoplasmic copper-zinc SOD (CuZn-SOD) (26), a mitochondrial manganese SOD (Mn-SOD) (3) and an extracellular SOD of high molecular weight (EC-SOD) (23).Mammalian preimplantation embryos grown in vitro are likely to exhibit sub-optimal or retarded development (45). In rodents, for example, the 2-cell block phenomenon, i.e., the proliferation arrest of f...

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Section: Discussionmentioning

confidence: 99%

“…For example, they have phagocytotic properties and digest extracellular collagen matrix (21), and are also related to the maintenance of the fetal allograft (18). Predecidual cells also have endocrinologic functions; they synthesize and release prolactin (PRL) which is biologically and immunologically equipotent with pituitary PRL (5).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical assessment of superoxide dismutase expression in the human endometrium throughout the menstrual cycle.

Narimoto

Noda

Shiotani

et al. 1990

Acta Histochem. Cytochem

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“…Little is known about the mechanisms which regulate the decidualization of the endometrium, although this transformation is probably linked to hormonal and stro mal microenvironmental factors, for which these stromal cells may represent both a preferential target and source [7,12,13].…”

Section: Discussionmentioning

confidence: 99%

“…As is commonly known, they then change into decidual cells which carry out several functions in pregnancy development, playing a role in pro tein secretion [3], in trophoblast invasivity control [4], and in protecting the embryo from maternal rejection [5,6], In addition these cells are involved in producing extracellular matrix components, such as fibronectin, laminin and glycosaminoglycans, which seem to be able to facilitate em bryo entry through stromal tissue [7,8].…”

Section: Introductionmentioning

confidence: 99%

Placental Villi-Decidua Interactions in Normal and Hypertensive Pregnancies: A Morphological Quantitative Study

Biagini

Pugnaloni

Carboni

et al. 1992

Gynecol Obstet Invest

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The decidual response to the implantation of the embryo is characterized by physical modifications to the uterine wall, with proliferation of the stromal cells which later change into decidual cells. We performed associated morphological and morphometrical studies to assess how the placental villi and decidua intersect, both in normal terminal pregnancy and in hypertensive patients in whom microenvironmental modifications induced by hypertension may cause significant alterations in mother-fetus relationships. In placentas of hypertensive women our morphometric analyses showed a higher number of chorionic villi-decidua interactions (p < 0.05) with a more clumped distribution (p < 0.05) and a smaller surface area of single interaction (p < 0.001), in association with a higher number (p < 0.005), and greater areas (p < 0.01) of decidual cells. These data demonstrate how the placenta can enhance mother-fetus contacts impaired as the result of a hypertensive condition.

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“…A significant uterine change during early implantation is decidualization, which involves the replication and differentiation of certain stromal fibroblasts within the endometrium (Kearns & Lala, 1983). By Day 6 of pregnancy, the embryo is attached to the luminal epithelium and is found within an implantation chamber.…”

Section: Introductionmentioning

confidence: 99%

Collagen concentrations in dissected tissue compartments of rat uterus on Days 6, 7 and 8 of pregnancy

Clark¹,

Hurst²,

Myers³

et al. 1992

Reproduction

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Summary. Implantation and non-implantation sites were dissected into myometrial and stromal components; a decidual/embryonic region was obtained on Days 7 and 8 of pregnancy. The concentration of collagen (as a percentage of the dry weight of tissue), measured by hydroxyproline analysis, was significantly lower in the implantation regions than in the non-implant regions in all areas studied. The concentrations in the antimesometrial myometrium and stroma of the implantation region remained the same over the days studied. In contrast, the mesometrial collagen concentration in the implantation region declined from Day 6 to Day 8 of pregnancy. Collagen concentration was low within the decidual/embryonic tissue on Days 7 and 8 of pregnancy. Remodelling of collagen within the embryonic area appears to be an important feature of the uterine response to implantation in rats.

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Life History of Decidual Cells: A Review*

Cited by 77 publications

References 30 publications

Immunohistochemical assessment of superoxide dismutase expression in the human endometrium throughout the menstrual cycle.

Immunohistochemical assessment of superoxide dismutase expression in the human endometrium throughout the menstrual cycle.

Placental Villi-Decidua Interactions in Normal and Hypertensive Pregnancies: A Morphological Quantitative Study

Collagen concentrations in dissected tissue compartments of rat uterus on Days 6, 7 and 8 of pregnancy

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