Life Experience of Patients With Unilateral Vocal Fold Paralysis

Francis, David O.; Sherman, Ariel; Hovis, Kristen L.; Bonnet, Kemberlee; Schlundt, David G.; Garrett, C. Gaelyn; Davies, Louise

doi:10.1001/jamaoto.2018.0067

Cited by 46 publications

(38 citation statements)

References 25 publications

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“…Consequently, most of these surgeries generated unnecessary direct and indirect medical costs, patient anxiety and diminished productivity during recovery, and complications. Although high‐volume thyroid surgeons report relatively low surgical complication rates of 1% to 3%, approximately 26% to 81% of patients undergo surgery with low‐volume surgeons whose complication rates generally are much higher, including hypothyroidism, clinically severe hypocalcemia/hypoparathyroidism, recurrent laryngeal nerve injury, and, less commonly, infection and bleeding . Higher surgical complication rates have been reported among the elderly, who are heavily represented in the thyroid nodule population.…”

Section: Introductionmentioning

confidence: 99%

Extending expressed RNA genomics from surgical decision making for cytologically indeterminate thyroid nodules to targeting therapies for metastatic thyroid cancer

Ali

Siperstein

Sadow

et al. 2019

Cancer Cytopathology

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The Afirma Genomic Sequencing Classifier (GSC) is a rule‐out test for malignancy/noninvasive follicular thyroid neoplasms with papillary‐like nuclear features among patients with Bethesda category III/IV nodules, whereas the complimentary Xpression Atlas provides genomic insights from a curated panel of 511 genes among GSC suspicious and Bethesda category V/VI nodules. Together, they facilitate personalized treatment decisions based on genomic insights derived from the transcriptome of the biopsied target and extend the diagnostic and therapeutic reach of cytopathologists and fine‐needle aspiration biopsy sample collection.

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Section: Introductionmentioning

confidence: 99%

Extending expressed RNA genomics from surgical decision making for cytologically indeterminate thyroid nodules to targeting therapies for metastatic thyroid cancer

Ali

Siperstein

Sadow

et al. 2019

Cancer Cytopathology

View full text Add to dashboard Cite

show abstract

“…There are also no randomized trials that have defined the optimal follow-up strategy for men following their initial treatment for localized prostate cancer. The natural history of prostate cancer following a prostate-specific antigen relapse does not necessarily predict the development of metastases or death [28, 29]. Although long-term outcomes are better with early treatment for a prostate-specific antigen-only recurrence, these results may reflect the natural history of the disease and do not necessarily reflect a benefit from therapy.…”

Section: Discussionmentioning

confidence: 99%

Actionable Locoregional Relapses after Therapy of Localized Esophageal Cancer: Insights from a Large Cohort

et al. 2018

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Objective: The goal of surveillance after therapy of localized esophageal cancer (LEC) is to identify actionable relapses amenable to salvage; however, the current surveillance algorithms are not optimized. We report on a large cohort of LEC patients with actionable locoregional relapses (LRRs). Methods: Between 2000 and 2013, 127 (denominator = 752) patients with actionable LRR were identified. Histologic/cytologic confirmation was the gold standard. All surveillance tools (imaging, endoscopy, fine needle aspiration) were assessed. Results: Most patients were men (89%), had adenocarcinoma (79%), and had no new symptoms (72%) when diagnosed with LRR. In trimodality patients, endoscopic confirmation of positron emission tomography-computed tomography-suspected LRR occurred in only 44%, and 56% required additional tools (e.g., fine needle aspiration). Alternatively, in bimodality patients, endoscopy confirmed LRRs in 81%. Trimodality patients had a higher risk of subsequent LRR/distant metastases after the first LRR than the bimodality patients (p = 0.03). In all patients, 78% of the subsequent relapses were distant. For patients who were salvaged, survival was significantly prolonged (50.6 vs. 25.1 months, p < 0.01). Conclusions: Patients live longer after successful salvage of the LRR than if salvage is not possible. After LRR, patients have a high risk of subsequent distant metastasis and whether the second relapse is local or distant, survival is uniformly poor.

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“…An abnormal total score on a dysphagia self‐report questionnaire. For this study, we recorded the presence of dysphagia when the DHI total score > 5, or EAT‐10 total score > 2 The presence of signs or symptoms of dysphagia was documented by the clinician during the evaluation.…”

Section: Methodsmentioning

confidence: 99%

“…The presence of signs or symptoms of dysphagia was documented by the clinician during the evaluation. This definition included both patient‐reported symptoms and clinician‐observed signs Instrumental assessment of swallowing (i.e., FEES or MBS) was recommended and completed based on findings from the clinical evaluation …”

Section: Methodsmentioning

confidence: 99%

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Prevalence, incidence, and characteristics of dysphagia in those with unilateral vocal fold paralysis

et al. 2019

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Objectives/Hypothesis The purpose of this study was to investigate the impact of dysphagia definition on the incidence and overall prevalence of dysphagia in patients with unilateral vocal fold paralysis (UVP) stratified by etiology. Study Design Retrospective medical chart review. Methods Data was collected from the records of individuals diagnosed with UVP from 2013 to 2018, including patient demographics, dysphagia questionnaire total scores, clinical evaluation dysphagia symptoms, and instrumental swallow assessment outcomes. The annual incidence and overall prevalence of dysphagia were calculated by etiology as counts and percentages across five operational definitions of dysphagia. Results A total of 415 individuals met inclusion criteria for the study. Annual prevalence estimates ranged from 19% to 55%, depending on the definition of dysphagia used. The highest prevalence of dysphagia occurred when defined by symptoms or signs identified by the clinician (55%). The lowest prevalence of dysphagia occurred using a definition of abnormal swallowing function documented during instrumental assessment (19%). Dysphagia questionnaire scores were more frequently abnormal in those with iatrogenic than idiopathic etiology of UVP (adjusted P = 0.014). Rate of instrumental assessment and documentation of aspiration was highest for central UVP etiology (33%). On average, pneumonia was rare (6%) irrespective of UVP etiology. Conclusion Up to 55% of patients diagnosed with UVP complained of dysphagia, but only 21% had dysphagia symptoms severe enough to prompt instrumental assessment. Incidence and severity of dysphagia varied depending on UVP etiologic category as well as dysphagia definition. The etiology of UVP may impact dysphagia risk and severity in this population and warrants further investigation. Level of Evidence IV Laryngoscope, 130:2397–2404, 2020

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Life Experience of Patients With Unilateral Vocal Fold Paralysis

Cited by 46 publications

References 25 publications

Extending expressed RNA genomics from surgical decision making for cytologically indeterminate thyroid nodules to targeting therapies for metastatic thyroid cancer

Extending expressed RNA genomics from surgical decision making for cytologically indeterminate thyroid nodules to targeting therapies for metastatic thyroid cancer

Actionable Locoregional Relapses after Therapy of Localized Esophageal Cancer: Insights from a Large Cohort

Prevalence, incidence, and characteristics of dysphagia in those with unilateral vocal fold paralysis

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