Life expectancy in people with newly diagnosed epilepsy

Gaitatzis, Athanasios

doi:10.1093/brain/awh267

Cited by 127 publications

(83 citation statements)

References 15 publications

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“…This is based on the assumptions that the average onset age for adult epilepsy is 40 years and average life expectancy for patients with epilepsy is 70 years, roughly 10 years shorter than that for the general population. 16 The impact of these assumptions was evaluated via sensitivity analyses.…”

Section: Figure 1 Decision Tree Model Of 3 Treatment Strategies For Amentioning

confidence: 99%

Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore

Dong

Sung²,

Finkelstein³

2012

Neurology

115

102

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Because of the different population allele frequencies of HLA-B*1502 among different ethnic groups, genotyping for HLA-B*1502 and providing alternate AEDs to those who test positive is cost-effective for Singaporean Chinese and Malays, but not for Singaporean Indians. Population frequency of HLA-B*1502, PPV, duration of treatment relative to life expectancy, and costs of alternative drugs are the key drivers influencing cost-effectiveness.

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Section: Figure 1 Decision Tree Model Of 3 Treatment Strategies For Amentioning

confidence: 99%

Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore

Dong

Sung²,

Finkelstein³

2012

Neurology

115

102

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“…In addition, inhibitory and excitatory effects of hyperhomocysteinemia may contribute to long-term AED side-effects on the central nervous system like fatigue and cognitive impairment in addition to the increased risk for ischemic heart disease (+34%) and fatal cardiovascular disease (+68%) in individuals with epilepsy (Gaitatzis et al 2004). …”

Section: Discussionmentioning

confidence: 99%

Chronic homocysteine exposure causes changes in the intrinsic electrophysiological properties of cultured hippocampal neurons

et al. 2013

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Homocystinuria is an inborn error of metabolism characterized by plasma homocysteine levels up to 500 M, premature vascular events and mental retardation. Mild elevations of homocysteine plasma levels up to 25 M, which are common in the general population, are associated with vascular disease, cognitive impairment and neurodegeneration. Several mechanisms of homocysteine neurotoxicity have been investigated. However, information on putative effects of hyperhomocysteinemia on the electrophysiology of neurons is limited. To screen for such effects, we examined primary cultures of mouse hippocampal neurons with the whole-cell patch-clamp technique. Homocysteine was applied intracellularly (100 M), or cell cultures were incubated with 100 M homocysteine for 24 h. Membrane voltage was measured in current-clamp mode, and action potential firing was induced with short and prolonged current injections. Single action potentials induced by short current injections (5 ms) were not altered by acute application or incubation of homocysteine. When we elicited trains of action potentials with prolonged current injections (200 ms), a broadening of action potentials during repetitive firing was observed in control neurons. This spike broadening was unaltered by acute application of homocysteine. However, it was significantly diminished when incubation with homocysteine was extended to 24 h prior to recording. Furthermore, the number of action potentials elicited by low current injections was reduced after long-term incubation with homocysteine, but not by the acute application. After 24 h of homocysteine incubation, the input resistance was reduced which might have contributed to the observed alterations in membrane excitability. We conclude that homocysteine exposure causes changes in the intrinsic electrophysiological properties of cultured hippocampal neurons as a mechanism of neurological symptoms of hyperhomocysteinemia.

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“…Weibull models have been used to evaluate life expectancy or time to event in the literature. [4,8,9] The models were adjusted for age, gender, race, Census region (Northeast, Midwest, South, West), receipt of public support for Medicare premium (state Medicare buy-in), patient health status (Charlson index and specific comorbidities), type of diagnosed fracture (pathologic, traumatic), site of service (inpatient or outpatient), per capita income (based on county of residence), physician specialty (orthopaedic surgeon, neurosurgeon, interventional radiologist, other), year of diagnosis and type of treatment (non-operated vs operated, kyphoplasty vs vertebroplasty vs non-operated).…”

Section: Survivorship Analysismentioning

confidence: 99%