Life expectancy in keratoconus.

Moodaley, L C M; Woodward, E. Geoffrey; Liu, C. S. C.; Buckley, Roger

doi:10.1136/bjo.76.10.590

Cited by 239 publications

(20 citation statements)

References 4 publications

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“…These findings are consistent with the observations made by corneal specialists concerning the loss or absence of older KC patients. [3][4][5][6] The question remains to be answered as to where the older KC patients are if they are not being examined in these practices? The following analysis examines possible reasons for the loss or absence of KC patients.…”

Section: Discussionmentioning

confidence: 99%

“…1 There are several reports linking KC and connective tissue disorders other than Ehlers-Danlos syndrome, such as osteogenesis imperfecta and mitral valve prolapse (MVP). 3 Could it be that patients with KC have a shorter life expectancy owing to underlying connective tissue-related disease? 3 There is evidence for a link between KC and MVP.…”

Section: Associated Diseasesmentioning

confidence: 99%

“…2 Corneal specialist ophthalmologists have made the observation that few keratoconic patients in older age groups are evaluated. [3][4][5][6] Several reports provide data related to this topic: Lass et al 8 found that 10% of 417 KC patients seen at a University-based corneal referral center were older than 50 years. 7 This was a 4-year study with mean baseline ages of 26 for men and 28 for women.…”

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confidence: 98%

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Quo Vadis Older Keratoconus Patients? Do They Die at Younger Ages?

McMonnies

2013

Cornea

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An absence or loss of older KC patients has been found in some specialist contact lens fitting practices. Notwithstanding the possible influence of numerous other issues, the absence or loss of KC patients may be because of reduced life expectancy, a topic that seems to warrant further examination. There may be implications for improving the understanding of the pathogenesis of KC if reduced life expectancy can be confirmed and the associated reasons elucidated.

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Section: Discussionmentioning

confidence: 99%

Section: Associated Diseasesmentioning

confidence: 99%

mentioning

confidence: 98%

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Quo Vadis Older Keratoconus Patients? Do They Die at Younger Ages?

McMonnies

2013

Cornea

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“…As the mortality rate of keratoconics is similar to the normal population 14 and most do not undergo surgery, 15 the majority should be wearing contact lenses beyond their 50s. However, as keratoconics demonstrate periods of stability 8-12 years post diagnosis, 16 older individuals may be managed more frequently by community Optometrists and hence their relative under-representation.…”

Section: Discussionmentioning

confidence: 99%

The Dundee University Scottish Keratoconus study: demographics, corneal signs, associated diseases, and eye rubbing

Weed

MacEwen

Giles

et al. 2007

Eye

228

164

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Aim To investigate and correlate the corneal, refractive, topographic and familial characteristics of a large cohort with keratoconus. Methods Prospective observational study of 200 consecutive patients presenting with keratoconus during the 4 year-period 1997-2000. Subjects were examined at enrolment and at a final review. Data were collected on demographic characteristics, referral route, symptoms, refractive correction, eye rubbing, family history, medical history, slit-lamp biomicroscopic corneal signs, and computerized corneal topography. Results Mean age at enrolment was 30.9710.4 (range, 12.2-72) years (N ¼ 200, 62.5% male, 93% white Caucasian) with a 5% family history of keratoconus. Atopic diseases included asthma (23%), eczema (14%), and hay fever (30%). Only 9% wore contact lenses before referral. Mean follow-up was 1004 days 7282 (range, 390-1335) and 9.778.9 (range, 1.1-60) years from diagnosis. The mean simulated K1 corneal power at enrolment was 51.7475.36 (range, 42.59-67.32) D and 88.5% exhibited bilateral keratoconus. Fifty-three (15%) topographically confirmed cones exhibited no clinical corneal signs at presentation. At enrollment, 56% had a pachymetry o0.480 mm increasing to 77% at final review. Forty-eight percent of subjects reported significant eye rubbing and there was a highly statistically significant difference (two sample t-test P ¼ 0.018) between keratoconus and control groups. TMS-2 axial corneal power was strongly associated with corneal scarring and age at diagnosis. The size of the scarring effect was 2.2 D (95% confidence interval (CI) 1.34, 3.06). Conclusions This study provides an overview of a large population with keratoconus highlighting presenting features and clinical and topographic progression over a 4 year-period.

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“…It has been inferred that keratoconic patients may have a higher mortality rate than unaffected population, possibly due to some complications or associated diseases, such as obesity, 21 although the mortality rate of keratoconus was found to be similar in the normal population. 100 However, improved diagnostic methods and associated increased detection of subtle forms of keratoconus may give rise to an apparently increasing incidence, if some less severe cases remain undetected in older age groups. Increased rates of diagnosing keratoconus may also be associated with increased interest in assessing corneas for refractive surgery.…”

Section: Age Differencesmentioning

confidence: 99%

The Epidemiology and Etiology of Keratoconus

Gordon‐Shaag¹,

Millodot²,

Shneor³

2012

International Journal of Keratoconus and Ectatic Corneal Diseases

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Keratoconus is a noninflammatory disorder characterized by ectasia of the central or inferior portion of the cornea. This review presents the scant epidemiological information known to date and the factors believed to cause the development of the disease. They are the genetic factors for which evidence come from family studies, twin studies and genetic loci. There appears to be multiple genes causing a keratoconus phenotype with variable penetration. However, the genetic predisposition might not be enough; environmental factors, such as eye rubbing, atopy and UV exposure, may have a role in generating the disease.

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Life expectancy in keratoconus.

Abstract: (Tables 1 and 2).There was no significant difference between the general population mortality rate and that of the keratoconus sample [x2= 1*59 (males), x2=

Cited by 239 publications

References 4 publications

Quo Vadis Older Keratoconus Patients? Do They Die at Younger Ages?

Quo Vadis Older Keratoconus Patients? Do They Die at Younger Ages?

The Dundee University Scottish Keratoconus study: demographics, corneal signs, associated diseases, and eye rubbing

The Epidemiology and Etiology of Keratoconus

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