Life Expectancy Gains From Cancer Prevention Strategies for Women With Breast Cancer and <EMPH TYPE="ITAL">BRCA1</EMPH> or <EMPH TYPE="ITAL">BRCA2</EMPH> Mutations

Abstract

Interventions to prevent second cancers, particularly PCM, may offer substantial LE gain for young women with BRCA-associated early-stage breast cancer. Estimates of LE gain may help women and their physicians consider the uncertainties, risks, and advantages of these interventions and lead to more informed choices about cancer prevention strategies.

Prophylactic Surgery to Reduce Breast Cancer Risk: A Brief Literature Review

“…The magnitude of these gains is least for women with low‐penetrance mutations (assumed contralateral breast cancer risk of 24% and ovarian cancer risk of 6%) and greatest for those with high‐penetrance mutations (assumed contralateral breast cancer risk of 65% and ovarian cancer risk of 40%). As expected, older age and poorer prognosis from primary breast cancer further attenuate these gains (13).…”

Prophylactic Surgery to Reduce Breast Cancer Risk: A Brief Literature Review

“…The magnitude of these gains is least for women with low‐penetrance mutations (assumed contralateral breast cancer risk of 24% and ovarian cancer risk of 6%) and greatest for those with high‐penetrance mutations (assumed contralateral breast cancer risk of 65% and ovarian cancer risk of 40%). As expected, older age and poorer prognosis from primary breast cancer further attenuate these gains (13).…”

Estimates of the likely prophylactic effect of tamoxifen in women with high risk BRCA1 and BRCA2 mutations

“…There is some support for a substantial benefit of tamoxifen in prevention of contralateral tumours in mutation-positive breast cancer cases, from a retrospective casecontrol study (Narod et al, 2000). Simulation studies also suggest a secondary preventive effect (Schrag et al, 2000). Our results suggest a modest primary preventive effect, which is stronger in BRCA2 positive women than in BRCA1 positive.…”

Results from the Delivery of a Community Health Worker Training to Advance Competencies in Cancer Genomics

“…88% (n = 23) of CHWs stated that the materials were "just right" and all CHWs stated that the quality of the training matched expectations (n = 10, 38%) or was better than expected (n = 16, 62%). Quality of instruction was highly ranked, with all participants stating that instructors used strategies that kept them engaged (n = 26, 100%), and instructors were highly ranked (M = 5, range [3][4][5].…”

Prophylactic Surgery to Reduce Breast Cancer Risk: A Brief Literature Review

“…The magnitude of these gains is least for women with low‐penetrance mutations (assumed contralateral breast cancer risk of 24% and ovarian cancer risk of 6%) and greatest for those with high‐penetrance mutations (assumed contralateral breast cancer risk of 65% and ovarian cancer risk of 40%). As expected, older age and poorer prognosis from primary breast cancer further attenuate these gains (13).…”

Estimates of the likely prophylactic effect of tamoxifen in women with high risk BRCA1 and BRCA2 mutations

“…There is some support for a substantial benefit of tamoxifen in prevention of contralateral tumours in mutation-positive breast cancer cases, from a retrospective casecontrol study (Narod et al, 2000). Simulation studies also suggest a secondary preventive effect (Schrag et al, 2000). Our results suggest a modest primary preventive effect, which is stronger in BRCA2 positive women than in BRCA1 positive.…”

Results from the Delivery of a Community Health Worker Training to Advance Competencies in Cancer Genomics

“…88% (n = 23) of CHWs stated that the materials were "just right" and all CHWs stated that the quality of the training matched expectations (n = 10, 38%) or was better than expected (n = 16, 62%). Quality of instruction was highly ranked, with all participants stating that instructors used strategies that kept them engaged (n = 26, 100%), and instructors were highly ranked (M = 5, range [3][4][5].…”

Prophylactic Surgery to Reduce Breast Cancer Risk: A Brief Literature Review

“…The magnitude of these gains is least for women with low‐penetrance mutations (assumed contralateral breast cancer risk of 24% and ovarian cancer risk of 6%) and greatest for those with high‐penetrance mutations (assumed contralateral breast cancer risk of 65% and ovarian cancer risk of 40%). As expected, older age and poorer prognosis from primary breast cancer further attenuate these gains (13).…”

Estimates of the likely prophylactic effect of tamoxifen in women with high risk BRCA1 and BRCA2 mutations

“…There is some support for a substantial benefit of tamoxifen in prevention of contralateral tumours in mutation-positive breast cancer cases, from a retrospective casecontrol study (Narod et al, 2000). Simulation studies also suggest a secondary preventive effect (Schrag et al, 2000). Our results suggest a modest primary preventive effect, which is stronger in BRCA2 positive women than in BRCA1 positive.…”

Results from the Delivery of a Community Health Worker Training to Advance Competencies in Cancer Genomics

“…88% (n = 23) of CHWs stated that the materials were "just right" and all CHWs stated that the quality of the training matched expectations (n = 10, 38%) or was better than expected (n = 16, 62%). Quality of instruction was highly ranked, with all participants stating that instructors used strategies that kept them engaged (n = 26, 100%), and instructors were highly ranked (M = 5, range [3][4][5].…”