Life events preceding the onset of panic disorder

Faravelli, Carlo

doi:10.1016/0165-0327(85)90016-3

Cited by 114 publications

(69 citation statements)

References 11 publications

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“…Several studies have shown that anxious adults report a significantly greater number of life events in the 12 months prior to the onset of their most recent clinical episode in comparison to controls (Blazer et al 1987;Faravelli 1985;Finlay-Jones and Brown 1981), although the evidence has not been completely consistent (Rapee et al 1990;Roy-Byrne et al 1986). In contrast, few studies of this nature have been conducted with anxious children.…”

mentioning

confidence: 97%

Severe Life Events and Chronic Adversities as Antecedents to Anxiety in Children: A Matched Control Study

Allen

Rapee

Sandberg

2008

J Abnorm Child Psychol

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The present study compared the number of severe life events and chronic adversities as reported retrospectively by mothers of children with an anxiety disorder (n=39) prior to the onset of their most recent episode, with controls (n=39) matched for age and sex. The parent version of the Psychosocial Assessment of Childhood Experiences (PACE) was used to assess chronic adversities (long-term experiences with negative impact on child) and severe life events (discrete life events with high long-term threat). A significantly greater number of severe life events and chronic adversities were assessed prior to onset for anxious children compared to controls. The finding for severe life events held regardless of whether impact ratings were assigned by mothers or a panel of independent raters, suggesting the findings reflect actual as opposed to perceived differences. Results suggest that both discrete and chronic stressors may constitute risk for future episodes of anxiety in children.

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mentioning

confidence: 97%

Severe Life Events and Chronic Adversities as Antecedents to Anxiety in Children: A Matched Control Study

Allen

Rapee

Sandberg

2008

J Abnorm Child Psychol

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“…These disorders are considered stress-related because stressful life events are associated with their onset and severity [4][5][6][7]. Indeed, risk for developing panic disorder and depression is related to the number of life stressors the patient experiences [4,5,8]. PTSD is, by definition, preceded by exposure to a traumatic event [9].…”

Section: Introductionmentioning

confidence: 99%

Sex differences in stress responses: a critical role for corticotropin-releasing factor

2018

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Rates of post-traumatic stress disorder, panic disorder, and major depression are higher in women than in men. Another shared feature of these disorders is that dysregulation of the stress neuropeptide, corticotropin-releasing factor (CRF), is thought to contribute to their pathophysiology. Therefore, sex differences in responses to CRF could contribute to this sex bias in disease prevalence. Here, we review emerging data from non-human animal models that reveal extensive sex differences in CRF functions ranging from its presynaptic regulation to its postsynaptic efficacy. Specifically, detailed are sex differences in the regulation of CRF-containing neurons and the amount of CRF that they produce. We also describe sex differences in CRF receptor expression, distribution, trafficking, and signaling. Finally, we highlight sex differences in the processes that mitigate the effects of CRF. In most cases, the identified sex differences can lead to increased stress sensitivity in females. Thus, the relevance of these differences for the increased risk of depression and anxiety disorders in women compared to men is also discussed.

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“…Yapılan çalışmalarda, PB grubunun %53'ünde çocukluk döneminde aileden ayrılmanın olduğu, PB+Ago'li hastaların, normal deneklere göre, çocukluk ve ergenlikte ana-baba ölümü, aileden uzamış ayrılık, ana-babanın boşanması gibi travmatik yaşam olaylarını daha fazla yaşadıkları bildirilmiştir 29,30,31,32,33 . Araştırmamızda depresyonu olan hastalarda altı yaşından önce annelerinden altı aydan fazla ayrı kalma oranının diğer gruplara göre anlamlı olarak fazla olduğu belirlenmiştir.…”

Section: Discussionunclassified

Panik Bozuklukta Yaşam Kalitesi: 3 Aylık İzlem Çalışması

Altıntaş¹,

Uğuz²,

Levent³

2015

Cukurova Medical Journal

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Purpose: Panic Disorder is a common psychiatric condition which is higher risk for substance abuse, suicide attempts and functional disability. It is 2-3 times more common in women and estimated to range from 1,4% to 3,8% of the general population. Studies reported that quality of life in Panic Disorder is negatively affected and overall health (emotional and psyhical health), social activities, risk of unemployment increases. The aim of this study was investigate the affects of quality of life on panic disorder and depression and follow the treatment response after the 3 months. Material and Methods: 22 women and 9 men (total 31) within in age range of 20-73(mean age 40,3±12,9) diagnosed as Panic Disorder; 27 women and 15 men (total 42) within in age range of 18-57(mean age 33,6 ±11,5) diagnosed as Panic Disorder with Agoraphobia; 54 women and 19 men (total 73) within in age 20-69(mean age 38,5 ±11,7) diagnosed on Major Depression were included to study.Psychiatric interview were carried out using Structured Clinical İnterview for Diagnose(SCID-I), Sociodemographic Data Form, Hamilton Anxiety Scale (HAM-A), Hamilton Depression Scale(HAM-D), Panic and Agoraphobia Scale and Endicott's Work Productivity Scale (EWPS) were applied in 0.,1.,3. months. Results: Quality of life had negatively affected in all of the groups. In this study we found significant impairment in pain, general health, energy, social function, emotional role disability and mental health subgroups of quality of life scale

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Life events preceding the onset of panic disorder

Cited by 114 publications

References 11 publications

Severe Life Events and Chronic Adversities as Antecedents to Anxiety in Children: A Matched Control Study

Severe Life Events and Chronic Adversities as Antecedents to Anxiety in Children: A Matched Control Study

Sex differences in stress responses: a critical role for corticotropin-releasing factor

Panik Bozuklukta Yaşam Kalitesi: 3 Aylık İzlem Çalışması

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