Life events and disability in rheumatoid arthritis: a European cohort

Leymarie, F.; Jolly, Damien; Sanderman, Robbert; Briançon, Serge; Marchand, Andrée-Anne; Guillemin, Françis; Eschard, Jean-Paul; Suurmeijer, Th.P.B.M.; Poitrinal, Priscille; Blanchard, F.; Heuvel, Wilco van den

doi:10.1093/rheumatology/36.10.1106

Cited by 20 publications

(11 citation statements)

References 24 publications

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“…This compares with a previous study (53) but is at variance with observed correlations of major life events (54) and minor stress (13) with ESR in RA. Also, pain did not correlate with life events in our study, and this agrees with the findings by Klages (9) but conflicts with the observation of correlation between next-day pain and daily hassles in patients with more disease activity and a history of major life events (6).…”

Section: Discussionsupporting

confidence: 54%

Biopsychosocial mediators and moderators of stress-health relationships in patients with recently diagnosed rheumatoid arthritis

Dekkers¹,

Geenen²,

Evers³

et al. 2001

Arthritis & Rheumatism

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Section: Discussionsupporting

confidence: 54%

Biopsychosocial mediators and moderators of stress-health relationships in patients with recently diagnosed rheumatoid arthritis

Dekkers¹,

Geenen²,

Evers³

et al. 2001

Arthritis & Rheumatism

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“…45 A study in a large sample of 370 patients with RA indicated that major life events do not affect the course of early RA in an obvious manner. 46 Patients were questioned three times at 1-year intervals about life events in the previous year. The occurrence of deaths of relatives or acquaintances did not seem to modify patient status.…”

Section: Resultsmentioning

confidence: 99%

“…Positive life events (and at a marginally significant level also negative life events) suggested a protective effect on functional disability, but these life events were not related to disease activity (Ritchie's index) or perceived overall health. 46 It has also been suggested that major life events may lead to a deterioration of health. Patients (n = 14) who reported to have experienced more severe life events in the past 6 months experienced more current physical disability.…”

Section: Resultsmentioning

confidence: 99%

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The Impact of Stressors on Health Status and Hypothalamic‐Pituitary‐Adrenal Axis and Autonomic Nervous System Responsiveness in Rheumatoid Arthritis

Geenen

Middendorp

Bijlsma

2006

Annals of the New York Academy of Sciences

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The hypothalamic-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS) are critically involved in inflammation and are activated by stress. This suggests that stressful circumstances may affect the chronic inflammation of rheumatoid arthritis (RA). Fifty-six scientific publications of the past 15 years were reviewed to get insight into the possible impact of stressors (grouped in five categories) on the health status and HPA axis and ANS functioning of adult patients with RA. Our findings in this review were: (1) In response to mental and physical effort and applied physiological stressors, patients demonstrate ANS hyporesponsiveness and "too normal" HPA axis responsiveness considering the elevated immune activity. A premorbid defect, past and current inflammatory activity, past and current stress, and physical deconditioning may explain disturbed physiological responses. (2) After brief naturalistic stressors, self-perceived and clinician's ratings of disease activity are increased; inflammation parameters have been insufficiently examined. (3) Major life events do not univocally affect disease status, but appear able to modify disease activity in a positive or negative way, depending on the nature, duration, and dose of the accompanying physiological stress response. (4) Enduring (e.g., work-related or interpersonal) stressors are associated with perceived health. Because this stressor category mingles with personality variables, the mere observation of a correlation does not prove that chronic stressors provoke health changes, although this might be the case. (5) Not one study rigorously examined the prospective hypothesis that past stressors (e.g., childhood victimization or pre-onset stressful incidents) may trigger RA or aggravate existing RA, which is a realistic belief for some patients.

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“…The emotions they may feel (e.g. fear, anger, depression, 8–10 anxiety, 8,9 , 11,12 frustration combined with pain and physical limitations), to a great extent, can increase their level of stress 13,14 and destroy patients’ well‐being feelings 5,15 . So, the presence of significant psychological stress in the lives of people with RA is well documented.…”

Section: Introductionmentioning

confidence: 99%

The effect of Benson Relaxation Technique on rheumatoid arthritis patients: Extended report

Bagheri-Nesami¹,

Mohseni-Bandpei²,

Shayestehazar³

2006

Int J of Nursing Practice

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Rheumatoid arthritis (RA) is a chronic disease and has the highest rate of prevalence among rheumatic inflammatory diseases. The purpose of this study was to determine the effect of Benson Relaxation Technique (BRT) combined with medication on disease activity in patients with RA. Following ethical approval, 50 consecutive matched patients were selected and allocated into two groups, either an experimental or a control group. Patients in the experimental group received BRT combined with medication and patients in the control group were given only medication. Clinical symptoms, laboratory findings, anxiety, depression and feeling of well-being were measured before and after intervention to evaluate the effect of BRT. There was a significant difference between the two groups in anxiety, depression and feeling of well-being. Changes in clinical symptoms and laboratory findings were not large enough to be statistically significant between the two groups, but they indicated decline in disease progress. The results demonstrate that BRT can be an effective technique in reducing disease process in patients suffering from RA. However, in order to support the findings of this trial, studies with large sample size and > 8-week intervention are recommended.

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Life events and disability in rheumatoid arthritis: a European cohort

Cited by 20 publications

References 24 publications

Biopsychosocial mediators and moderators of stress-health relationships in patients with recently diagnosed rheumatoid arthritis

Biopsychosocial mediators and moderators of stress-health relationships in patients with recently diagnosed rheumatoid arthritis

The Impact of Stressors on Health Status and Hypothalamic‐Pituitary‐Adrenal Axis and Autonomic Nervous System Responsiveness in Rheumatoid Arthritis

The effect of Benson Relaxation Technique on rheumatoid arthritis patients: Extended report

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