“…Commercially available chitosans produced by chemical methods vary mostly on their degree of acetylation (DA) and molar mass. In addition, using enzymatic and biorefinery approaches, Moerschbacher from our University, has pursued the objective of obtaining a new generation of chitosans with specific non-random PAs [ 12 ]. To be termed “chitosan”, the deacetylated chitin should contain at least 60% of d -glucosamine residues [ 13 ], which corresponds to a degree of acetylation of 40% (i.e., degree of deacetylation 60%).…”
The widespread emergence of antibiotic-resistant bacteria has highlighted the urgent need of alternative therapeutic approaches for human and animal health. Targeting virulence factors that are controlled by bacterial quorum sensing (QS), seems a promising approach. The aims of this study were to generate novel nanoparticles (NPs) composed of chitosan (CS), sulfo-butyl-ether-β-cyclodextrin (Captisol®) and/or pentasodium tripolyphosphate using ionotropic gelation technique, and to evaluate their potential capacity to arrest QS in bacteria. The resulting NPs were in the size range of 250–400 nm with CS70/5 and 330–600 nm with CS70/20, had low polydispersity index (<0.25) and highly positive zeta potential ranging from ζ ~+31 to +40 mV. Quercetin, a hydrophobic model flavonoid, could be incorporated proportionally with increasing amounts of Captisol® in the NPs formualtion, without altering significantly its physicochemical properties. Elemental analysis and FTIR studies revealed that Captisol® and quercetin were effectively integrated into the NPs. These NPs were stable in M9 bacterial medium for 7 h at 37 °C. Further, NPs containing Captisol® seem to prolong the release of associated drug. Bioassays against an E. coli Top 10 QS biosensor revealed that CS70/5 NPs could inhibit QS up to 61.12%, while CS70/20 NPs exhibited high antibacterial effects up to 88.32%. These results suggested that the interaction between NPs and the bacterial membrane could enhance either anti-QS or anti-bacterial activities.
“…Commercially available chitosans produced by chemical methods vary mostly on their degree of acetylation (DA) and molar mass. In addition, using enzymatic and biorefinery approaches, Moerschbacher from our University, has pursued the objective of obtaining a new generation of chitosans with specific non-random PAs [ 12 ]. To be termed “chitosan”, the deacetylated chitin should contain at least 60% of d -glucosamine residues [ 13 ], which corresponds to a degree of acetylation of 40% (i.e., degree of deacetylation 60%).…”
The widespread emergence of antibiotic-resistant bacteria has highlighted the urgent need of alternative therapeutic approaches for human and animal health. Targeting virulence factors that are controlled by bacterial quorum sensing (QS), seems a promising approach. The aims of this study were to generate novel nanoparticles (NPs) composed of chitosan (CS), sulfo-butyl-ether-β-cyclodextrin (Captisol®) and/or pentasodium tripolyphosphate using ionotropic gelation technique, and to evaluate their potential capacity to arrest QS in bacteria. The resulting NPs were in the size range of 250–400 nm with CS70/5 and 330–600 nm with CS70/20, had low polydispersity index (<0.25) and highly positive zeta potential ranging from ζ ~+31 to +40 mV. Quercetin, a hydrophobic model flavonoid, could be incorporated proportionally with increasing amounts of Captisol® in the NPs formualtion, without altering significantly its physicochemical properties. Elemental analysis and FTIR studies revealed that Captisol® and quercetin were effectively integrated into the NPs. These NPs were stable in M9 bacterial medium for 7 h at 37 °C. Further, NPs containing Captisol® seem to prolong the release of associated drug. Bioassays against an E. coli Top 10 QS biosensor revealed that CS70/5 NPs could inhibit QS up to 61.12%, while CS70/20 NPs exhibited high antibacterial effects up to 88.32%. These results suggested that the interaction between NPs and the bacterial membrane could enhance either anti-QS or anti-bacterial activities.
“…; Munoz et al. ). These tools are adapted to the consequential approach, as they integrate the technical and geographic constraints and account for the political agenda as well as the projected future power demand.…”
Section: Methodsmentioning
confidence: 97%
“…The choice of the approach is generally determined by the sectors and areas of concern linked to the decision under study. In consequential studies in which the electricity sector plays an important role, energy scenarios from energy system models or other simulation tools are often used Roux et al 2017;Ghose et al 2017;Munoz et al 2017). These tools are adapted to the consequential approach, as they integrate the technical and geographic constraints and account for the political agenda as well as the projected future power demand.…”
Summary
Stationary batteries are projected to play a role in the electricity system of Switzerland after 2030. By enabling the integration of surplus production from intermittent renewables, energy storage units displace electricity production from different sources and potentially create environmental benefits. Nevertheless, batteries can also cause substantial environmental impacts during their manufacturing process and through the extraction of raw materials. A prospective consequential life cycle assessment (LCA) of lithium metal polymer and lithium‐ion stationary batteries is undertaken to quantify potential environmental benefits and drawbacks. Projections are integrated into the LCA model: Energy scenarios are used to obtain marginal electricity supply mixes, and projections about the battery performances and the recycling process are sourced from the literature. The roles of key parameters and methodological choices in the results are systematically investigated. The results demonstrate that the displacement of marginal electricity sources determines the environmental implications of using batteries. In the reference scenario representing current policy, the displaced electricity mix is dominated by natural gas combined cycle units. In this scenario, the use of batteries generates environmental benefits in 12 of the 16 impact categories assessed. Nevertheless, there is a significant reduction in achievable environmental benefits when batteries are integrated into the power supply system in a low‐carbon scenario because the marginal electricity production, displaced using batteries, already has a reduced environmental impact. The direct impacts of batteries mainly originate from upstream manufacturing processes, which consume electricity and mining activities related to the extraction of materials such as copper and bauxite.
“…The “green character” of chitosan, which has already been reported in the literature [ 58 , 59 ], together with the multifunctionality that this biomacromolecule can provide to polymeric materials, fully justify its current use in different application sectors; besides, its chemical structure and composition have suggested an unexpected applicability in the field of flame retardance, aiming at designing new flame retardant formulations suitable for different polymer substrates (namely, bulky polymers, fabrics, foams and wood). In particular, chitosan has started to be considered a valuable carbon source, usually in combination with other flame retardant additives that may effectively interact with chitosan, thus enhancing the overall FR performance; indeed, the possibility of its conversion into a stable (aromatic) protective char makes this biomacromolecule very appealing.…”
Section: Conclusion and Future Perspectivesmentioning
During the last decade, the utilization of chitin, and in par0ticular its deacetylated form, i.e. chitosan, for flame retardant purposes, has represented quite a novel and interesting application, very far from the established uses of this bio-sourced material. In this context, chitosan is a carbon source that can be successfully exploited, often in combination with intumescent products, in order to provide different polymer systems (namely, bulky materials, fabrics and foams) with high flame retardant (FR) features. Besides, this specific use of chitosan in flame retardance is well suited to a green and sustainable approach. This review aims to summarize the recent advances concerning the utilization of chitosan as a key component in the design of efficient flame retardant systems for different polymeric materials.
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