Life Course Outcomes of Young People With Anxiety Disorders in Adolescence

Woodward, Lianne J.; Fergusson, David M.

doi:10.1097/00004583-200109000-00018

Cited by 892 publications

(528 citation statements)

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“…Furthermore, our previous research reported that psychological symptoms and disorders in late adolescence were associated with psychological symptoms in emerging adulthood. 61 Other investigators have also found that psychological symptoms are stable over time (e. g., 62,63 ). A consistent family environment and/or genetic predispositions might be contributing to the significance of psychological symptoms as a predictor of psychiatric disorders.…”

Section: Discussionmentioning

confidence: 99%

Utilization of Mental Health Services by Minority Urban Adults: Psychosocial Predictors

et al. 2014

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Although most mental disorders have their first onset by young adulthood, there are few longitudinal studies of these problems and related help-seeking behavior. The present study examined some early and current predictors of the use of mental health services among African-American and Puerto Rican participants in their mid-30s. The 674 participants (52.8 % African Americans, 47.2 % Puerto Ricans; 60.1 % women) in this study were first seen in 1990 when the participants attended schools serving the East Harlem area of New York City. A structural equation model controlling for the participants' gender, educational level in emerging adulthood, and age at the most recent data collection showed significant standardized pathways from both ethnicity (β=−0.28; z= −4.82; pG0.001) and psychological symptoms (β=0.15; z=2.41; pG0.05), both measured in emerging adulthood, to smoking in the early 30s. That, in turn, was associated with certain physical diseases and symptoms (i.e., respiratory) in the mid-30s (β=0.16; z=2.59; pG0.05). These physical diseases and symptoms had a cross-sectional association with family financial difficulty in the mid-30s (β=0.21; z=4.53; pG0.001), which in turn also had a cross-sectional association with psychiatric disorders (β=0.30; z=5.30; pG0.001). Psychiatric disorders had a cross-sectional association with mental health services utilization (β=0.65; z=13.25; pG0.001). Additional pathways from the other domains to mental health services utilization in the mid-30s were also supported by the mediating role of psychiatric disorders. Results obtained from this research offer theoretical and practical information regarding the processes leading to the use of mental health services.

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Section: Discussionmentioning

confidence: 99%

Utilization of Mental Health Services by Minority Urban Adults: Psychosocial Predictors

et al. 2014

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“…Anxiety disorders are among the most prevalent psychiatric disorders in children and adolescents and predict great burden into adulthood (Copeland et al, 2014;Merikangas et al, 2010;Weems and Silverman, 2013;Woodward and Fergusson, 2001). Separation, social, and generalized anxiety disorder (GAD) are particularly common among youth, with relatively early ages of onset and high rates of co-occurence with each other (Mohatt et al, 2014;Verduin and Kendall, 2003).…”

Section: Introductionmentioning

confidence: 99%

Prefrontal Reactivity to Social Signals of Threat as a Predictor of Treatment Response in Anxious Youth

Kujawa

Swain

Hanna

et al. 2015

Neuropsychopharmacol

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Neuroimaging has shown promise as a tool to predict likelihood of treatment response in adult anxiety disorders, with potential implications for clinical decision-making. Despite the relatively high prevalence and emergence of anxiety disorders in youth, very little work has evaluated neural predictors of response to treatment. The goal of the current study was to examine brain function during emotional face processing as a predictor of response to treatment in children and adolescents (age 7-19 years; N = 41) with generalized, social, and/ or separation anxiety disorder. Prior to beginning treatment with the selective serotonin reuptake inhibitor (SSRI) sertraline or cognitive behavior therapy (CBT), participants completed an emotional faces matching task during functional magnetic resonance imaging (fMRI). Whole brain responses to threatening (ie, angry and fearful) and happy faces were examined as predictors of change in anxiety severity following treatment. Greater activation in inferior and superior frontal gyri, including dorsolateral prefrontal cortex and ventrolateral prefrontal cortex, as well as precentral/postcentral gyri during processing of threatening faces predicted greater response to CBT and SSRI treatment. For processing of happy faces, activation in postcentral gyrus was a significant predictor of treatment response. Post-hoc analyses indicated that effects were not significantly moderated by type of treatment. Findings suggest that greater activation in prefrontal regions involved in appraising and regulating responses to social signals of threat predict better response to SSRI and CBT treatment in anxious youth and that neuroimaging may be a useful tool for predicting how youth will respond to treatment.

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“…In particular, studies that examined the association of depression and anxiety disorders with subsequent school termination found either that the association does not exist when viewed prospectively (Johnson, Cohen, Dohrenwend, Link, & Brook, 1999) or that, where it exists, it is attributable entirely (Fergusson & Woodward, 2002;Miech, Caspi, Moffitt, Wright, & Silva, 1999) or in large part (McLeod & Kaiser, 2004;Woodward & Fergusson, 2001) to childhood adversities that precede the onset of disorders and are likely to have independent effects on educational attainment. On the other hand, studies examining impulse-control and substance use disorders have found associations with subsequent school termination that remain significant after accounting for childhood adversities.…”

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confidence: 99%