Liesegang rings in a submental mass: Fine‐needle aspiration with histologic correlation

Abstract

Liesegang rings are lamellated concretions commonly found in chronic cystic lesions that are inflamed, necrotic, fibrotic, or hemorrhagic. We report on an unusual case of a 14-yr-old girl with an acute, rapidly enlarging solid submental mass in which Liesegang rings were identified on aspirate smears.

Biliary deposition of Liesegang rings presenting as a polypoid mass in the liver: Previously unrecognized lesion

“…To study the organs in which LR can be formed, we reviewed the English‐language literature regarding LR in a PubMed search encompassing the years 1987–2008. The results are summarized in Table 1 2–19,27–36 . As described here, LR were frequently seen in the kidney ( n = 25) and breast ( n = 22), followed by synovium ( n = 8), female genital tract ( n = 8), and eyelid and conjunctiva ( n = 4).…”

“…Diagnostic procedure was recorded in 77 cases, and LR were most commonly diagnosed using surgical specimens ( n = 38), followed by fine‐needle aspiration ( n = 32). Occasionally, LR present as a tumor‐like mass, and in these instances clinical suspicion of malignancy can arise, as occurred in the present case 2–4,9,12,27–29,32,33,36 . On immunohistochemistry there is no reliable marker for diagnosis of LR, but in some cases LR have contained calcium, hemosiderin, glycogen, acid mucopolysaccharide, and amyloid 2,5,9,12,28,29,32,34,35 …”

Liesegang structures and pseudofungi in a cystic renal cell carcinoma aspirate

“…The Liesegang structures seen in surgical pathology and cytology are round or oval structures which usually measure 50‐150 (range 10‐800) μm and show concentric rings and radial striations and sometimes an amorphous central nidus. They are usually eosinophilic, but have been occasionally described as basophilic in histologic sections and aspirate smears . Before they were recognized as such, these structures were sometimes confused with parasites or their eggs, like ova of Trichuris trichiura or Ascaris lumbricoides , developing larvae, and cross‐sections of Dioctophyma renale.…”

“…They are usually eosinophilic, [6][7][8][9][10] but have been occasionally described as basophilic in histologic sections 11 and aspirate smears. 12 Before they were recognized as such, these structures were sometimes confused with parasites or their eggs, 6,13 like ova of Trichuris trichiura or Ascaris lumbricoides, developing larvae, and cross-sections of Dioctophyma renale. Liesegang rings have been encountered both in surgical pathology and FNA material from various benign cysts and inflammatory processes, but especially in renal cysts, [14][15][16][17] apocrine and other breast cysts, [18][19][20] and endometriotic cysts.…”

Confocal Laser Scanning Microscopy of Liesegang Rings in Odontogenic Cysts: Analysis of Three-Dimensional Image Reconstruction

“…A few cases have been described more rarely in the maxillary sinus, pleura, peritoneus (endometrium), omentum, pericardium, epididymus, and fallopian tubes. They have been confused with material extraneous, various parasites (such as Dioctophyma renale or Echinoccoccus), eggs, larva, (monorifrangent cellular structures, clear, with regular borders and homogeneous composition), algas, psammoma bodies, aspecific calcifications, corpora amilacea (concretions of calcium, found in prostate, brain, and lung but not associated to inflammatory processes), bodies of Guttman-Michaelis (concretions of calcium and iron, recovered in the bladder (urinaria), characterized from concentric and in partnership laminations to inflammatory events) [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The presence of LRs in biopsy specimen is an occasional finding, because the exact mechanism of formation and composition of these peculiar rings is unknown.…”