Liesegang Rings: Extremely Rare Structures in Malignant Lesions

Sancheti, Sankalp; Jain, Shivani

doi:10.1177/1066896917722389

Cited by 5 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their occurrence in malignant lesions is exceptional, and, in addition to the current case, Liesegang rings were reported in a single case of endometrioid ovarian carcinoma . A recent report describes Liesegang rings in a case of medullary thyroid carcinoma; however, since they stained with Congo red, they would be better classified as globular (spheroid) amyloid with concentric laminations.…”

supporting

confidence: 46%

Liesegang structures and pseudofungi in a cystic renal cell carcinoma aspirate

Niğdelioğlu

Biemer

Pambuccian

2018

Diagnostic Cytopathology

View full text Add to dashboard Cite

supporting

confidence: 46%

Liesegang structures and pseudofungi in a cystic renal cell carcinoma aspirate

Niğdelioğlu

Biemer

Pambuccian

2018

Diagnostic Cytopathology

View full text Add to dashboard Cite

“…For example, the so-called blue blobs (Bbs) described by Milligan et al [5] may be a source of misdiagnosis in postmenopausal vaginal smears, since they simulate malignancy. Likewise, a few structures such as crystals or Liesegang rings have been confused with parasitic organisms and may be associated with malignancy [6,7]. Herein, we describe previously unrecognized atypical material in a Mascagni-Lund's lymph node from a specimen obtained after cholecystectomy for acute cholecystitis.…”

Section: Introductionmentioning

confidence: 92%

Blue Blob-Like Bodies Mimicking Malignancy

Nava¹

2020

BJSTR

View full text Add to dashboard Cite

Background: Incidental morphologic findings in lymph node tissue may represent a diagnostic challenge in surgical pathology. We have characterized, for the first time to our knowledge, dense globular structures that most likely represent degenerated lymphoid cells found in a Mascagni-Lund's lymph node, and resemble Blue Blobs (Bbs) described in vaginal Papanicolaou-stained smears, or Hematoxylin Bodies (Hbs) commonly seen in patients diagnosed with Systemic Lupus Erythematosus (SLE), respectively. These Blue Blob-Like Bodies (Bbbs) are not associated with SLE, and immunohistochemistry may be necessary to rule out malignancy or viral infection.Objective: To characterize Blue Blob-Like Bodies (Bbbs) in a Mascagni-Lund's lymph node from a cholecystectomy specimen performed for acute cholecystitis. Materials and Method:A paraffin-embedded cholecystectomy specimen that included a Mascagni-Lund's lymph node was evaluated by routine microscopy in a busy surgical pathology service. Special stains, immunohistochemistry, and electron microscopy were performed to characterize the unusual structures observed.Results: Many scattered, round-to-oval, dense globular basophilic novel structures with smooth borders were identified and named Blue Blob-Like Bodies (Bbbs). Conclusion:Bbbs mimic malignant (primary or metastatic) or virally infected cells in lymph node tissue. However, they most likely represent degenerated lymphoid cells resulting from reactive lymphadenopathy secondary to acute cholecystitis.Pathologists need to recognize Bbbs and properly distinguish them from other pathological structures, in order to avoid misdiagnosis.

show abstract