Lidocaine/tetracaine peel in topical anesthesia prior to laser-assisted hair removal: Phase-II and Phase-III study results

Alster, Tina S.; Garden, Jerome M.; Fitzpatrick, Richard; Rendon, Marta; Sarkany, Marlis; Adelglass, Jeffrey

doi:10.3109/09546634.2012.715240

Cited by 18 publications

(15 citation statements)

References 6 publications

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“…As LT cream forms a self‐occlusive film when exposed to air, it is said to not require plastic occlusion. LT cream has shown superiority over placebo in pain reduction during several dermatological laser procedures, and lower pain scores compared with LP cream during (superficial) single‐pass CO 2 laser skin resurfacing . However, apart from this single study, no head‐to‐head studies have been performed for other dermatological indications or laser systems.…”

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confidence: 99%

Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials

et al. 2016

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SummaryBackground Pain is a common adverse effect of dermatological laser procedures. Currently, no standard topical anaesthetic cream exists for deeper dermal laser procedures. Objectives To compare the efficacy of lidocaine/tetracaine cream and lidocaine/ prilocaine cream in reducing self-reported pain during deeper dermal laser treatment of acne keloidalis nuchae (AKN) and tattoos. Methods We conducted two randomized, double-blind, controlled clinical trials with intrapatient, split-lesion designs: study A included patients with AKN (n = 15); study B included patients with black tattoos (n = 15). The primary end point was the patients' self-reported pain on a 10-cm visual analogue scale (VAS). Secondary objectives were the percentage of patients with adequate pain relief, willingness to pay €25 for the cream that provided the best pain relief and safety of the creams. Results In both studies, VAS scores were lower for lidocaine/prilocaine cream, with a mean VAS difference in study A of 1Á9 [95% confidence interval (CI) 1Á0-2Á8] and in study B of 0Á6 (95% CI À0Á7 to 1Á9). In study A, adequate pain relief was achieved in 13% (n = 2) with lidocaine/tetracaine cream vs. 73% (n = 11) with lidocaine/prilocaine cream (P = 0Á004), and in study B in 53% (n = 8) vs. 80% (n = 12), respectively (P = 0Á289). In study A, 47% (n = 7) were willing to pay an additional €25 vs. 73% (n = 11) in study B. No serious adverse events occurred. Conclusions Lidocaine/prilocaine cream under plastic occlusion is the preferred topical anaesthetic during painful laser procedures targeting dermal chromophores.

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confidence: 99%

Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials

et al. 2016

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“…on the effect of lidocaine/tetracaine (LT) peel in topical anesthesia prior to laser-assisted hair removal, the results showed that VAS scores were significantly lower for LT peel (26.7 for LT peel vs. 44.3 for placebo), and for that study and ours, subjects’/investigators’ ratings favored LT peel were evaluated which are in accordance. [13] Therefore, the combination of lidocaine 7% and tetracaine 7% provides rapid anesthesia onset with minimal side effects, and could be a practical alternative for older local anesthetic agents used before laser-assisted hair removal and also improves patient satisfaction.…”

Section: Discussionmentioning

confidence: 99%

The effects and side effects of lidocaine tetracaine peel off on laser-assisted hair removal

et al. 2014

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Background:Lidocaine 7%-tetracaine 7% is one of the combinations recently offered for performing laser-assisted hair removal. The aim of this study was to compare the effects of this combination with placebo on the side effects of laser-assisted hair removal.Materials and Methods:This clinical trial was carried out on 110 women who referred to Isfahan Spadana laser clinic for laser-assisted hair removal. Lidocaine 7%-tetracaine 7% was applied on one-half of the face, whereas placebo was applied on the other side to create local anesthesia, and after 30 min, the place was cleaned and investigated for complications (edema, erythema, and pallor); then laser therapy was begun. At the end of the therapy, the patients’ pain was estimated using Visual Analog Scale (VAS). The data were analyzed using SPSS software by Chi-square and paired t-tests.Results:The mean age of patients was 27.74 ± 10.8 years. Average levels of anesthesia at 30 min after using lidocaine 7%-tetracaine 7% and placebo based on VAS were 3.6 ± 1.4 and 8.4 ± 1.5, respectively (P = 0.001). In other words, patients felt less pain by using lidocaine 7%-tetracaine 7%. The frequency of complications in patients was not significantly different between the two groups.Conclusion:Considering the better effect of lidocaine 7%-tetracaine 7% compared to placebo and its minimal side effects, we can use it before performing laser-assisted hair removal.

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“…Average application dose ranges from 0.9 to 1.7 g/10 cm 2 . Studies also demonstrate that application on an area up to 400 cm 2 for as long as 120 min produced a maximum peak plasma lidocaine concentration of 0.220 μg/mL, which is far below the lower toxic limits of lidocaine [33].…”

Section: Novel Lidocaine/tetracaine Formulationsmentioning

confidence: 97%

“…The product incorporates lidocaine 7 % and tetracaine 7 % (Pliaglis, Galderma, SA) providing fast and prolonged relief during dermatologic procedures [33]. The self-occluding, air-drying agent is applied to involved skin and easily peels off after only 30 min.…”

Section: Novel Lidocaine/tetracaine Formulationsmentioning

confidence: 99%

Local Anesthesia: Evidence, Strategies, and Safety

et al. 2015

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The number of office-based procedures performed utilizing local anesthesia continues to rise, particularly in dermatologic settings. As more emphasis is placed on cost effectiveness in medicine, it is important to understand the role that office-based procedures can play in providing excellent dermatologic care. In addition, it is essential to continually demonstrate that local anesthesia administered in office-based settings is safe and effective in order to maintain a high standard of care within the specialty. Achieving adequate local anesthesia is imperative to ensure patient comfort, reduce anxiety, and promote optimal outcomes. The clinician should have a comprehensive understanding of the pathophysiology, mechanism of action, practical applications and techniques, and potential adverse events of various topical and injectable anesthetics in order to enhance patient satisfaction and safety. Lidocaine, which is the most commonly used local anesthetic, has a rapid onset, moderate duration, and excellent safety profile, making it a staple in office-based procedures.

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Lidocaine/tetracaine peel in topical anesthesia prior to laser-assisted hair removal: Phase-II and Phase-III study results

Abstract: After a 30-min application, LT peel was effective and well-tolerated in providing anesthesia for laser-assisted hair removal.

Cited by 18 publications

References 6 publications

Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials

Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials

The effects and side effects of lidocaine tetracaine peel off on laser-assisted hair removal

Local Anesthesia: Evidence, Strategies, and Safety

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