Lidocaine lubricants for intubation-related complications: a systematic review and meta-analysis

Nebulized pharmacological agents for preventing postoperative sore throat: A systematic review and network meta-analysis

“…Although several meta-analyses in the past few years have shown that ketamine[ 31 ], lidocaine[ 14 , 32 ], corticosteroids[ 33 – 35 ], magnesium[ 36 , 37 ], benzydamine hydrochloride[ 38 ], etc. could prevent POST, there has been no comprehensive comparison between active drugs.…”

“…The primary outcomes were the incidence of POST 1 hour and 24 hours after surgery/extubation, and the incidence of moderate to severe POST 24 hours after surgery/extubation, if information at 1 hour was not available, we used data ranging between 0 and 2 hours(if equidistant, we took the longer outcome). Because there is currently no uniformly definition for moderate to severe POST, we have adopted the commonly used 4-point scale(0–3) for evaluation and we elected to choose a threshold of at least two as the definition for moderate to severe POST[ 14 ]. The secondary outcomes were the incidence of postoperative cough and postoperative hoarseness 24h after surgery/extubation, and adverse effects.…”

Lidocaine lubricants for intubation-related complications: more details, more significance?

“…We read with great interest the recent systematic review and meta-analysis (SR-MA) from Liao et al 1 in the Journal. Their report explored the potential effects of lidocaine-based lubricants to prevent postoperative sore throat (POST).…”

“…First, the diagnostic criteria used for POST in the various studies included by Liao et al 1 is not clearly described and the reported incidence of POST is widely variable, ranging from 17.5 to 77% one hour after surgery and from 7.2 to 100% 24 hr after surgery. This high variation in the POST rate might be ascribed to differences in the individual study design or abilities of the anesthesiologists in each study, but could also be attributed to differences in diagnostic criteria for POST applied in each study.…”

“…In summary, although the study by Liao et al 1 is a useful report focusing on the prophylactic effect of lidocaine lubricants against POST, it is somewhat limited by the methodological issues mentioned above. Future work on POST should ensure the use of uniform criteria for POST assessment in high-quality adequately powered RCTs.…”