Lidocaine and Bupivacaine Mixtures for Epidural Blockade

Epidural anaesthesia with mixtures of bupivicaine and lidocaine

“…Other authors t2 have demonstrated similar findings when mixtures of bupivicaine and lidocalne hydrochloride were used for epidural blockade, and concluded that such mixtures produced less motor block than bupivicaine alone; this finding can probably be explained by the fact that the concentration of the bupivicaine in the mixture was 0.375 per cent but the control concentration of bupivicaine was 0.5 per cent. More recently, the results of a comprehensive study of mixtures of lidocalne hydrochloride and bupivicaine hydrochloride using a single dose epidural technique have been reported by Seow et al 3 The results of this study are similar to the present study, though a number of differences are present. Scow et al reported that for mixtures of lidocaine hydrochloride and bupivicaine the duration of action correlated closely with the fractional dose of bupiviealne in the solution, but that the latency of onset was similar to that of bupivicaine alone.…”

“…s Pharmacokinetic studies of mixtures of bupivicaine and lidoeaine hydrochloride have demonstrated blood concentrations below the toxic range and in fact blood concentrations are in the same range as if the components had been injected singly. 3 This approach to shortening the latent period of bupivicaine assumes that there is no interaction between the two agents injected, and that both behave as if the other agent were not present. However, mixtures of chloroprocalne and bupivicaine have been demonstrated to have a duration of action only slightly longer than chlorQprocalne alone and significantly shorter than bupivicaine alone.…”

Ropivacaína, articaína ou combinação de ropivacaína e articaína em anestesia peridural para cesariana: estudo randomizado, prospectivo e duplo-cego

“…On the other hand, our fi ndings contradict those of Donner et al 32 which state that a combination of epidurally administered bupivacaine-prilocaine provides faster and more intensive motor block. We are also contradicted by Seow et al 26 , in which a combination of bupivacaine-lidocaine provides more intensive motor block. In our study, motor block duration and level in the combination group was shorter and lower than the ropivacaine group, which we believe might have been caused by the fact that the differential block effect of ropivacaine emerges with greater strength in lower concentrations [11][12][13]33 .…”

The effect of addition of lidocaine to bupivacaine on anesthesia beginning time, block time, and block quality in lateral sagittal infraclavicular block

“…Although bupivacaine is a long-acting anesthetic and forms a long-lasting block, it has the longest onset time. A bupivacaine + lidocaine combination in epidural anesthesia is used for both the longer and deeper block effect of bupivacaine and the fast onset time of lidocaine (9). The effect time of this combination is like the effect time of bupivacaine alone, or it tends to be shorter (10,11).…”