Lidocaine and bupivacaine as part of multimodal pain management in a C57BL/6J laparotomy mouse model

Durst, Mattea; Arras, Margarete; Palme, Rupert; Talbot, Steven R.; Jirkof, Paulin

doi:10.1038/s41598-021-90331-2

Cited by 13 publications

(9 citation statements)

References 69 publications

(91 reference statements)

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“…The muscle and the skin of the abdomen were closed with a 5.0 silk suture, respectively. To reduce the postoperative pain, we injected lidocaine (10 mg/kg) in the incision margins (Durst et al, 2021). During the procedure, the temperature of warming pads was maintained at 37 • C. All surgical fields and instruments were maintained under aseptic conditions.…”

Section: Laparotomymentioning

confidence: 99%

Enriched Environment Prevents Surgery-Induced Persistent Neural Inhibition and Cognitive Dysfunction

Yang

Zhang

Tang

et al. 2021

Front. Aging Neurosci.

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Perioperative neurocognitive disorders (PND) encompass short-term delirium and long-term cognitive dysfunction. Aging increases the susceptibility to PND, yet the neural mechanism is not known. In this study, we monitored the dynamic changes of neuronal activity in the prelimbic cortex before and after surgery. We found that anesthesia combined with surgery, but not anesthesia alone, induced a prolonged decrease in neuronal activity during the post-operation period in the aged mice, but not in the adult mice. The prolonged decrease in neuronal activity was accompanied by surgery-induced microglial activation and proinflammatory cytokines expression. Importantly, we found that the enriched environment (EE) completely prevented both the prolonged neural inhibition and neuroinflammation, and improved cognitive function in the aged mice. These results indicate that the prolonged neural inhibition correlated to PND and that EE before the surgery could effectively alleviate the surgery- induced cognitive dysfunction.

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Section: Laparotomymentioning

confidence: 99%

Enriched Environment Prevents Surgery-Induced Persistent Neural Inhibition and Cognitive Dysfunction

Yang

Zhang

Tang

et al. 2021

Front. Aging Neurosci.

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“…Arras et al ( 97 ) provided one of the first reports describing a post-surgical reduction in nest quality following laparotomy. Follow-up studies from the same group further tested the assessment of nest building for detection of post-surgical pain in mice of both sexes and different strains ( 27 , 133 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, multimodal approaches were only applied in a small number of studies. In this context, it seems unfortunate that local anesthesia, which can efficaciously block the transduction of nociceptive signaling, is only rarely used in mice ( 133 ).…”

Section: Discussionmentioning

confidence: 99%

Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats—A systematic review

et al. 2022

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Several studies suggested an informative value of behavioral and grimace scale parameters for the detection of pain. However, the robustness and reliability of the parameters as well as the current extent of implementation are still largely unknown. In this study, we aimed to systematically analyze the current evidence-base of grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats. The following platforms were searched for relevant articles: PubMed, Embase via Ovid, and Web of Science. Only full peer-reviewed studies that describe the grimace scale, burrowing, and/or nest building as pain parameters in the post-surgical phase in mice and/or rats were included. Information about the study design, animal characteristics, intervention characteristics, and outcome measures was extracted from identified publications. In total, 74 papers were included in this review. The majority of studies have been conducted in young adult C57BL/6J mice and Sprague Dawley and Wistar rats. While there is an apparent lack of information about young animals, some studies that analyzed the grimace scale in aged rats were identified. The majority of studies focused on laparotomy-associated pain. Only limited information is available about other types of surgical interventions. While an impact of surgery and an influence of analgesia were rather consistently reported in studies focusing on grimace scales, the number of studies that assessed respective effects was rather low for nest building and burrowing. Moreover, controversial findings were evident for the impact of analgesics on post-surgical nest building activity. Regarding analgesia, a monotherapeutic approach was identified in the vast majority of studies with non-steroidal anti-inflammatory (NSAID) drugs and opioids being most commonly used. In conclusion, most evidence exists for grimace scales, which were more frequently used to assess post-surgical pain in rodents than the other behavioral parameters. However, our findings also point to relevant knowledge gaps concerning the post-surgical application in different strains, age levels, and following different surgical procedures. Future efforts are also necessary to directly compare the sensitivity and robustness of different readout parameters applied for the assessment of nest building and burrowing activities.

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“…The database AniMatch ( Table 1 ) connects scientists within Europe who are offering tissue or organs with scientists seeking this material. Scientists already sharing animal organs can support this process by describing it in publications and making peers aware of this possibility [ 77 ]. Specialized research communities also allow sharing of animal tissue or animal-derived products worldwide that are typically used in these fields on a collaborative basis via the SEARCH-framework [ 78 , 79 ].…”

Section: Introductionmentioning

confidence: 99%

A guide to open science practices for animal research

et al. 2022

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Translational biomedical research relies on animal experiments and provides the underlying proof of practice for clinical trials, which places an increased duty of care on translational researchers to derive the maximum possible output from every experiment performed. The implementation of open science practices has the potential to initiate a change in research culture that could improve the transparency and quality of translational research in general, as well as increasing the audience and scientific reach of published research. However, open science has become a buzzword in the scientific community that can often miss mark when it comes to practical implementation. In this Essay, we provide a guide to open science practices that can be applied throughout the research process, from study design, through data collection and analysis, to publication and dissemination, to help scientists improve the transparency and quality of their work. As open science practices continue to evolve, we also provide an online toolbox of resources that we will update continually.

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Lidocaine and bupivacaine as part of multimodal pain management in a C57BL/6J laparotomy mouse model

Cited by 13 publications

References 69 publications

Enriched Environment Prevents Surgery-Induced Persistent Neural Inhibition and Cognitive Dysfunction

Enriched Environment Prevents Surgery-Induced Persistent Neural Inhibition and Cognitive Dysfunction

Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats—A systematic review

A guide to open science practices for animal research

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