Lid-parallel conjunctival folds (LIPCOF) and dry eye: a multicentre study

Németh, János; Fodor, Eszter; Láng, Zsolt; Kosina-Hagyó, Krisztina; Berta, András; Komár, Timea; Petriček, Igor; Higazy, M. T.; Prost, M; Grupcheva, Christina; Kemer, Özlem Evren; Schollmayer, Petra; Samaha, Ameed; Hlavácková, K

doi:10.1136/bjophthalmol-2012-301580

Cited by 57 publications

(34 citation statements)

References 19 publications

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“…A possible reason for these results may be that when MGD occurred, the changes of lipid composition and quantity would affect the stability of tear film, causing the decline of BUT. Research [11] showed that there was significant correlation between conjunctivochalasis and MGD, that is, the heavier the degree of conjunctivochalasis, the higher the incidence of MGD. As for the negative results on tear film fragment, tear film foam, upper and lower tear meniscus height, and corneal fluorescein staining, previous studies indicate that there might be some correlation between these signs and the severity of dry eye symptoms [16].…”

Section: Discussionmentioning

confidence: 99%

“…according to Institute for Eye Research (IER), conjunctival congestion was graded as 0 (no congestion), 1 (congestion was confined to the fornix and blood vessel was bright red), 2 (congestion was obvious and reached to palpebral fissure and blood vessel was crimson and fuzzy), or 3 (congestion was diffuse, blood vessel was fuchsia, and meibomian gland texture was not clear); according to LIPCOF (Lid-parallel conjunctival folds) [11, 12], conjunctivochalasis was graded as 0 (no obvious fold), 1 (single fold), 2 (2 folds, but the height of the fold was lower than the height of tear film), or 3 (many folds, and the height of the fold was higher than the height of tear film). …”

Section: Methodsmentioning

confidence: 99%

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Correlation Analysis of Ocular Symptoms and Signs in Patients with Dry Eye

Song

Zhang

et al. 2017

Journal of Ophthalmology

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Purpose. To analyze the correlations between the ocular surface signs and symptoms in patients with dry eye. Methods. In this observational study, 176 dry eye patients, including 60 males and 116 females, were enrolled and their dry eye symptoms and ocular signs were observed. Partial correlation analysis was conducted between OSDI score and each ocular surface sign, and the correlations were further discussed in different age groups. Then multiple linear regression analysis was used to further explore the influence of these signs on OSDI score. Results. Our correlation analyses showed that rounding of lid margins, notching of lid margins, vascularity of lid margins, hyperkeratinization, plugging of orifices, main duct dropout, and conjunctival congestion all had a positive correlation with OSDI score, while main duct number (central 1 cm) and BUT had a negative one. Further analysis suggested that these correlations varied in different age groups. Multiple linear regression analysis indicated that main duct number (central 1 cm), rounding of lid margins, and hyperkeratinization significantly affected OSDI score. Conclusions. Close attention should be paid to the morphology and structure of the eyelid margin and the function of meibomian gland in the diagnosis, treatment, and follow-up of dry eye diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Correlation Analysis of Ocular Symptoms and Signs in Patients with Dry Eye

Song

Zhang

et al. 2017

Journal of Ophthalmology

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“…Bulbar and limbal hyperaemia can give an indication of ocular surface health and more recently the degree of both lid parallel conjunctival folding (LIPCOF) and lid wiper epitheliopathy (LWE) have been added to the list of potential indicators of dry eye. [5][6] [7] LIPCOF graded at least grade 2 is likely to be associated with dry eye symptoms [8].…”

Section: Introductionmentioning

confidence: 99%

Predicting success with silicone-hydrogel contact lenses in new wearers

Best

Drury²,

Wolffsohn

2013

Contact Lens and Anterior Eye

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2 AbstractPurpose: to evaluate changes in tear metrics and ocular signs induced by six months of silicone-hydrogel contact lens wear and the difference in baseline characteristics between those who successfully continued in contact lens wear compared to those that did not. Methods:Non-invasive Keratograph, Tearscope and fluorescein tear break-up times (TBUTs), tear meniscus height , bulbar and limbal hyperaemia, lid-parallel conjunctival folds (LIPCOF), phenol red thread, fluorescein and lissamine-green staining, and lid wiper epitheliopathy were measured on 60 new contact lens wearers fitted with monthly siliconehydrogels (average age 36±14years, 40 females). Symptoms were evaluated by the Ocular Surface Disease Index . After six months full time contact lens wear the above metrics were re-measured on those patients still in contact lens wear (n=33). The initial measurements were also compared between the group still wearing lenses after six months and those who had ceased lens wear (n=27).Results: There were significant changes in tear meniscus height (p=0.031), bulbar hyperaemia (p=0.011), fluorescein TBUT (p=0.027), corneal (p=0.007) and conjunctival (p=0.009) staining, LIPCOF (p=0.011) and lid wiper epitheliopathy (p=0.002) after six months of silicone-hydrogel wear. Successful wearers had a higher non-invasive (17.0s ± 8.2s vs 12.0s ± 5.6s; p=0.001) and fluorescein (10.7s ± 6.4s vs 7.5s ± 4.7s; p=0.001) TBUT than drop-outs, although OSDI (cut-off 4.2) was also a strong predictor of success. Conclusion:Silicone-hydrogel lenses induced significant changes in the tear film and ocular surface and lid margin staining. Wettability of the ocular surface is the main factor affecting contact lens drop-out.

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“…Analysis of the Presence and Absence of Lid-Wiper Epitheliopathy in Contact Lens Wearersstress caused by rubbing [18][19][20]. Among those, Pult et al18 reported that nasal LIPCOF was related to dry eye symptoms.…”

mentioning

confidence: 98%