Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases

Mammalian Target of Rapamycin Pathway Promotes Tumor-Induced Angiogenesis in Adenoid Cystic Carcinoma: Its Suppression by Isoliquiritigenin through Dual Activation of c-Jun NH2-Terminal Kinase and Inhibition of Extracellular Signal-Regulated Kinase

“…Although this natural flavonoid has been extensively considered as an antineoplastic agent in various human cancers (Hsu et al, 2005;Yoshida et al, 2008;Ye et al, 2009) and has shown inhibitory effects on the phorbol myristate acetateinduced angiogenic process of endothelial cells (Kang et al, 2010), this is the first study regarding prevention of tumor angiogenesis as an important component of the antitumor mechanisms of ISL. In this study, we demonstrated for the first time that ISL was a potent inhibitor of tumor-induced angiogenesis in ACC.…”

Chemopreventive Effects of Licorice and Its Components

“…These effects appeared to be at least partially associated with modulation of NF-κB, p38, and phosphatidylinositol 3-kinase (PI3-K)/protein kinase B (Akt) signaling [56]. ILQ was also able to attenuate phorbol myristate acetate (PMA)-induced expression of membrane type 1-MMP and MMP-2 in human umbilical vein endothelial cells (HUVECs) [57]. ILQ also inhibited PMA-induced migration and diminished PMA-stimulated JNKs and p38 signaling [57].…”

“…ILQ was also able to attenuate phorbol myristate acetate (PMA)-induced expression of membrane type 1-MMP and MMP-2 in human umbilical vein endothelial cells (HUVECs) [57]. ILQ also inhibited PMA-induced migration and diminished PMA-stimulated JNKs and p38 signaling [57].…”

Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone

“…Indeed, they are associated with several biologically active properties, including anti-inflammatory (Hsieh et al, 2000;Won et al, 2005), anti-oxidative (Nerya et al, 2004), anti-fungal (Sivakumar et al, 2009a), anti-bacterial (Sivakumar et al, 2009b), chemo-preventive and anti-cancer activities (Ducki, 2007;Chua et al, 2010;Katsori and Hadjipavlou-Litina, 2009;Liu and Go, 2006;Modzelewska et al, 2006). Although there are an increasing number of articles relating the anti-cancer activities of chalcones, limited information is available about a possible anti-angiogenic activity of this class of compounds (Kang et al, 2010;Kim et al, 2010;Mojzis et al, 2008). The structural features of chalcones presence of a reactive enone moiety and its relative flexibility compared to other related natural products predispose the template to interactions with diverse receptors and enzymes (Go et al, 2005), as well as their biological properties prompted us to investigate whether chalcones and newly synthesized cyclic chalcone analogues modulate angiogenesis in both in vitro and in vivo models.…”