Licorice Extracts Attenuate Nephrotoxicity Induced by Brucine Through Suppression of Mitochondria Apoptotic Pathway and STAT3 Activation

Zhang, Min; Wang, Chao; Cai, Hualin; Wen, Jing; Fang, Pingfei

doi:10.1007/s11596-019-2126-z

Cited by 8 publications

(4 citation statements)

References 47 publications

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“…In our study, we detected disruption of mitochondria in RTN3-null mouse kidneys. Previous studies have revealed that activation of the JAK2-STAT3 pathway may induce mitochondrial dysfunction and oxidative stress by disrupting the balance between BCL2 and BAX 43 , 44 . A specific JAK2 inhibitor can attenuate TNF-α-induced oxidative stress in renal tubular epithelial cells 45 .…”

Section: Discussionmentioning

confidence: 98%

Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells

Fan

Liu

et al. 2022

Exp Mol Med

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Reticulon 3 (RTN3) is an endoplasmic reticulum protein that has previously been shown to play roles in neurodegenerative diseases, but little is known about its function in the kidneys. The aim of the present study was to clarify the roles of RTN3 in chronic kidney disease (CKD) and kidney fibrosis. In this study, RTN3 levels were measured in kidney tissues from healthy controls and CKD or kidney fibrosis patients. An RTN3-null mouse model was generated to explore the pathophysiological roles of RTN3 in the kidneys. The underlying mechanisms were studied in primary proximal tubular epithelial cells and HEK293 cells in vitro. The results showed that (1) a reduction in RTN3 in mice induces CKD and kidney fibrosis; (2) decreased RTN3 expression is found in patients with CKD; (3) RTN3 plays critical roles in regulating collagen biosynthesis and mitochondrial function; and (4) mechanistically, RTN3 regulates these phenotypes by interacting with GC-Rich Promoter Binding Protein 1 (GPBP1), which activates the IGF2-JAK2-STAT3 pathway. Our study indicates that RTN3 might play crucial roles in CKD and kidney fibrosis and that a reduction in RTN3 in the kidneys might be a risk factor for CKD and kidney fibrosis.

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Section: Discussionmentioning

confidence: 98%

Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells

Fan

Liu

et al. 2022

Exp Mol Med

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“…Janus kinase/signal transducer and activator of transcription (JAK/STAT) is another in ammationrelevant signaling pathway can be modulated by polysaccharide, and this pathway closely linked to the secretion of cytokine IL-6 [138]. Similar to NF-κB signaling pathway, this pathway is a mediator of multiple cellular functions such as cell proliferation, cell differentiation and apoptosis [139]. Interestingly, recent research pointed out that JAK/STAT might perform as a connection between cytokine signaling and mitochondrial physiology.…”

Section: The Activation Of Anti-in Ammatory Signaling Pathwaymentioning

confidence: 99%

An overview of biological functions of natural polysaccharides: influence factors, mitochondria and signaling pathways

Guo

et al. 2023

Preprint

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Natural polysaccharide is a type of functional carbohydrate polymer under heated investigation. The structure of natural polysaccharides is in close relationship with their actual biological functions such as antioxidant, immunoregulation and antitumor effects. Herein, we have identified numerous factors that significantly affect the biological functions of polysaccharides, including molecular weight, degree of polymerization, hydrophilicity and metabolic capability. Mitochondria, as a key polysaccharide-targeting organelle, undergo a number of alterations during the treatment, which includes morphological changes, ROS production, membrane potential and permeability, ETC activity and ATP production. Intriguingly, polysaccharides exhibit protective effects and maintain mitochondrial function on normal cells, while in cancer cells, polysaccharides tend to accelerate apoptosis and exacerbate mitochondrial dysfunction. Numerous signaling pathways, including antioxidant signaling pathway, anti-inflammatory signaling pathway and apoptotic signaling pathway are activated correspondingly. This review underlines the significance of the structural features of the polysaccharide, and thereafter indicates the modes of physiological function.

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“…Brucine, a kind of monoterpene indole alkaloids extracted from the mature seeds of Strychnos nuxvomica Linn., has therapeutic effects on myasthenia gravis, rheumatoid arthritis, and hemiplegia caused by cerebrovascular diseases [88]. Brucine can inhibit auricle swelling caused by xylene in mice.…”

Section: Brucinementioning

confidence: 99%

Research Progress on Anti‐Inflammatory Effects and Mechanisms of Alkaloids from Chinese Medical Herbs

Liu

Chen

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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As the spectrum of diseases keeps changing and life pace keeps going faster, the probability and frequency of diseases caused by human inflammatory reactions also keep increasing. How to develop effective anti-inflammatory drugs has become the hotspot of researches. It has been found that alkaloids from Chinese medical herbs have anti-inflammatory, analgesic, antitumor, anticonvulsant, diuretic, and antiarrhythmic effects, among which the anti-inflammatory effect is very prominent and commonly used in the treatment of rheumatoid arthritis, ankylosing spondylitis, and other rheumatic immune diseases, but its mechanism of action has not been well explained. Based on this, this paper will classify alkaloids according to structural types and review the plant sources, applicable diseases, and anti-inflammatory mechanisms of 16 kinds of alkaloids commonly used in clinical treatment, such as berberine, tetrandrine, and stephanine, with the aim of providing a reference for drug researches and clinical applications. Isoquinoline AlkaloidsIsoquinoline alkaloids are widely distributed in 27 sections of plants, such as Menispermaceae, Berberidaceae, Papaveraceae, and Ranunculaceae [4]. Isoquinoline alkaloids, taking isoquinoline or tetrahydroisoquinoline as the basic parent nucleus, can be divided into 20 categories, including simple isoquinoline, benzylisoquinoline, phenethyl isoquinoline, naphthyl isoquinoline, aporphine, morphine,

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Licorice Extracts Attenuate Nephrotoxicity Induced by Brucine Through Suppression of Mitochondria Apoptotic Pathway and STAT3 Activation

Cited by 8 publications

References 47 publications

Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells

Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells

An overview of biological functions of natural polysaccharides: influence factors, mitochondria and signaling pathways

Research Progress on Anti‐Inflammatory Effects and Mechanisms of Alkaloids from Chinese Medical Herbs

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